Method for preparing curcumin nanoparticles by supercritical emulsification granulation technology

Abstract

The invention relates to a method for preparing curcumin nanoparticles by a supercritical emulsification granulation technology. The method comprises the following steps: S1, selecting one or more of absolute ethyl alcohol, methanol and acetone as a solvent, taking curcumin as a core material, taking lecithin and hyaluronic acid as wall materials, and taking genipin as a hyaluronic acid cross-linking agent; S2, enabling one solvent of the absolute ethyl alcohol, the methanol and the acetone to reach an emulsifying kettle through a high-pressure pump, adding a certain amount of curcumin and lecithin, and starting a magnetic stirrer to perform uniform stirring; S3, dissolving hyaluronic acid and genipin in purified water, and performing uniform stirring; S4, preparing a curcumin microemulsion; S5, introducing supercritical CO2 into a crystallization kettle, and pumping the curcumin microemulsion into the crystallization kettle through a nozzle; and S6, obtaining the curcumin nanoparticles with uniform particle size. According to the method, the curcumin nanoparticles are prepared under the low-temperature oxygen-free condition through the supercritical emulsification granulation technology, the activity of the curcumin nanoparticles is not prone to being damaged, operation conditions are accurate and controllable, reproducibility is good, and industrialization is easy.

Description

technical field [0001] The present invention relates to the field of preparation of curcumin nanoparticles, in particular to a method for preparing curcumin nanoparticles by supercritical emulsification granulation technology. Background technique [0002] Curcumin is a polyphenolic substance with a small molecular weight extracted from Zingiberaceae plants, and it is generally considered to be the most effective component in turmeric. Modern research has clearly proved that it has various pharmacological effects such as anti-tumor, anti-inflammation, and anti-oxidation, and has little toxic and side effects, and has a good prospect for clinical application. Curcumin has poor water solubility, and curcumin is sensitive to light and heat, easily oxidized, metabolized rapidly in the body, and the defects of low bioavailability limit the popularization and development of curcumin. [0003] In order to increase the bioavailability, it is known to utilize other components beside...

AI Technical Summary

Problems solved by technology

[0007] At present, there are still problems such as single wall material, poor water solubility and low bioavailability in the prepared curcumin granules, which seriously limit the promotion and application in food and biomedicine

Commonly used particle preparation methods such as: vacuum freeze drying, spray drying, microwave drying, etc., but the particles prepared by these methods have the disadvantages of large particle size and uneven distribution, solvent residue, not suitable for heat-sensitive substances, long time-consuming, high energy consumption, etc.

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