Method for preparing curcumin nanoparticles by supercritical emulsification granulation technology

A nanoparticle, curcumin technology, applied in pharmaceutical formulations, inactive medical preparations, food science and other directions, can solve the problems of inapplicability to heat-sensitive substances, poor water solubility, long time consumption, etc., to improve water solubility and bioavailability. Accurate and controllable operating conditions and improved particle stability

Pending Publication Date: 2021-08-06
普萃超临界(广东)高新技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, there are still problems such as single wall material, poor water solubility and low bioavailability in the prepared curcumin granules, which seriously limit the promotion and application in food and biomedicine
Commonly used particle preparation methods such as: vacuum freeze drying, spray drying, microwave drying, etc., but the particles prepared by these methods have the disadvantages of large particle size and uneven distribution, solvent residue, not suitable for heat-sensitive substances, long time-consuming, high energy consumption, etc.

Method used

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  • Method for preparing curcumin nanoparticles by supercritical emulsification granulation technology
  • Method for preparing curcumin nanoparticles by supercritical emulsification granulation technology

Examples

Experimental program
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Effect test

Embodiment 1

[0052] A kind of supercritical emulsification granulation technology prepares the method for curcumin nanoparticle, comprises the following steps:

[0053] Accurately measure 5L methanol, pour it into the emulsification kettle through a high-pressure pump, add 50g curcumin, 100g lecithin, turn on the magnetic stirring, the stirring power is 20KW, and the stirring time is 10min.

[0054] Dissolve 100g of hyaluronic acid and 10g of genipin in 5L of purified water, put the hyaluronic acid solution into the emulsification kettle through a high-pressure pump, continue to stir, and set the stirring power to 20KW, and the stirring time to 10min, to prepare curcumin microparticles lotion.

[0055] Supercritical CO with a high-pressure pump 2 Pass into the crystallization still with the flow velocity of 15g / mL, treat that temperature reaches 30 DEG C in the crystallization kettle, pressure reaches 10MPa, with another high-pressure pump the curcumin microemulsion is passed into the noz...

Embodiment 2

[0058] A kind of supercritical emulsification granulation technology prepares the method for curcumin nanoparticle, comprises the following steps:

[0059] Accurately measure 5L of acetone, pour it into the emulsification kettle through a high-pressure pump, add 100g of curcumin, 300g of lecithin, turn on the magnetic stirring, the stirring power is 25MPa, and the stirring time is 20min.

[0060] Dissolve 300g of hyaluronic acid and 30g of genipin in 5L of purified water, put the hyaluronic acid solution into the emulsification kettle through a high-pressure pump, continue to stir, and set the stirring power to 25MPa and the stirring time to 20min to prepare curcumin microparticles lotion.

[0061] Supercritical CO with a high-pressure pump 2 Pass into the crystallization still with the flow velocity of 15g / mL, treat that temperature reaches 40 DEG C in the crystallization kettle, pressure reaches 15MPa, with another high-pressure pump the curcumin microemulsion is passed int...

Embodiment 3

[0064] A kind of supercritical emulsification granulation technology prepares the method for curcumin nanoparticle, comprises the following steps:

[0065] Accurately measure 5L of absolute ethanol, pour it into the emulsification kettle through a high-pressure pump, add 150g of curcumin, 450g of lecithin, turn on the magnetic stirring, the stirring power is 30KW, and the stirring time is 30min.

[0066] Dissolve 450g of hyaluronic acid and 45g of genipin in 5L of purified water, put the hyaluronic acid solution into the emulsification kettle through a high-pressure pump, continue to stir, and set the stirring power to 30KW, and the stirring time to 30min, to prepare curcumin microparticles lotion.

[0067] Supercritical CO with a high-pressure pump 2 Pass into the crystallization still with the flow rate of 15g / mL, treat that temperature reaches 50 DEG C in the crystallization still, pressure reaches 30MPa, curcumin microemulsion is passed into the nozzle device of the cryst...

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Abstract

The invention relates to a method for preparing curcumin nanoparticles by a supercritical emulsification granulation technology. The method comprises the following steps: S1, selecting one or more of absolute ethyl alcohol, methanol and acetone as a solvent, taking curcumin as a core material, taking lecithin and hyaluronic acid as wall materials, and taking genipin as a hyaluronic acid cross-linking agent; S2, enabling one solvent of the absolute ethyl alcohol, the methanol and the acetone to reach an emulsifying kettle through a high-pressure pump, adding a certain amount of curcumin and lecithin, and starting a magnetic stirrer to perform uniform stirring; S3, dissolving hyaluronic acid and genipin in purified water, and performing uniform stirring; S4, preparing a curcumin microemulsion; S5, introducing supercritical CO2 into a crystallization kettle, and pumping the curcumin microemulsion into the crystallization kettle through a nozzle; and S6, obtaining the curcumin nanoparticles with uniform particle size. According to the method, the curcumin nanoparticles are prepared under the low-temperature oxygen-free condition through the supercritical emulsification granulation technology, the activity of the curcumin nanoparticles is not prone to being damaged, operation conditions are accurate and controllable, reproducibility is good, and industrialization is easy.

Description

technical field [0001] The present invention relates to the field of preparation of curcumin nanoparticles, in particular to a method for preparing curcumin nanoparticles by supercritical emulsification granulation technology. Background technique [0002] Curcumin is a polyphenolic substance with a small molecular weight extracted from Zingiberaceae plants, and it is generally considered to be the most effective component in turmeric. Modern research has clearly proved that it has various pharmacological effects such as anti-tumor, anti-inflammation, and anti-oxidation, and has little toxic and side effects, and has a good prospect for clinical application. Curcumin has poor water solubility, and curcumin is sensitive to light and heat, easily oxidized, metabolized rapidly in the body, and the defects of low bioavailability limit the popularization and development of curcumin. [0003] In order to increase the bioavailability, it is known to utilize other components beside...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/51A61K31/12A61K47/36A61K47/24A61P35/00A61P29/00A61P39/06A23L33/105A23L29/10
CPCA61K9/5161A61K9/5123A61K9/5192A61K31/12A61P35/00A61P29/00A61P39/06A23L33/105A23L29/10A23V2002/00
Inventor 胡勇刚陈改亭郭栋
Owner 普萃超临界(广东)高新技术有限公司
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