Niazoxanide pharmaceutical composition and preparation method thereof

A technology for nitazoxanide and composition is applied in the field of nitazoxanide pharmaceutical composition and preparation thereof, which can solve the problems of poor fluidity, accelerated degradation of nitazoxanide and the like, and achieves improved stability and simple and easy preparation method. , the effect of reducing the degree of degradation

Pending Publication Date: 2021-08-06
REYOUNG PHARMA
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The composition (ALINIA for oral suspension) in the prior art consists of sucrose, sodium benzoate, xanthan gum, microcrystalline cellulose-carboxymethylcellulose sodium, anhydrous citric acid, sodium citrate, strawberry essence, allure Composed of red pigment, the mass fraction of its prescription composition is mainly sucrose, the fluidity is mainly determined by the particle size of sucrose, there is a risk of poor fluidity, and sodium benzoate is a strong alkaline auxiliary material, which can accelerate the degradation of nitazoxanide

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Niazoxanide pharmaceutical composition and preparation method thereof
  • Niazoxanide pharmaceutical composition and preparation method thereof
  • Niazoxanide pharmaceutical composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] A pharmaceutical composition of nitazoxanide, made of the following components by weight percentage:

[0040]

[0041] Preparation:

[0042] (1) Mix sucrose, allure red aluminum lake, strawberry powder essence, and colloidal silicon dioxide in a single-column mixer with 5% by weight of the prescription amount to obtain a physical mixture;

[0043] (2) The above physical mixture is mechanically mixed in a pulverizing granulator to achieve the effect of mixing;

[0044] (3) Add nitazoxanide, xanthan gum, anhydrous citric acid, sodium citrate, microcrystalline cellulose-carboxymethyl cellulose sodium and the remaining amount of sucrose into a single-column mixer for mixing, and mix evenly. A dry suspension of nitazoxanide was obtained.

Embodiment 2

[0046] A pharmaceutical composition of nitazoxanide, made of the following components by weight percentage:

[0047]

[0048] Preparation:

[0049] (1) Mix sucrose, allure red aluminum lake, strawberry powder essence, and colloidal silicon dioxide in a single-column mixer with 5% by weight of the prescription amount to obtain a physical mixture;

[0050] (2) The above physical mixture is mechanically mixed in a pulverizing granulator to achieve the effect of mixing;

[0051] (3) Add nitazoxanide, xanthan gum, anhydrous citric acid, sodium citrate, microcrystalline cellulose-carboxymethyl cellulose sodium and the remaining amount of sucrose into a single-column mixer for mixing, and mix evenly. A dry suspension of nitazoxanide was obtained.

Embodiment 3

[0053] A pharmaceutical composition of nitazoxanide, made of the following components by weight percentage:

[0054]

[0055]

[0056] Preparation:

[0057] (1) Mix sucrose, allure red aluminum lake, strawberry powder essence, and colloidal silicon dioxide in a single-column mixer with 5% by weight of the prescription amount to obtain a physical mixture;

[0058] (2) The above physical mixture is mechanically mixed in a pulverizing granulator to achieve the effect of mixing;

[0059] (3) Add nitazoxanide, xanthan gum, anhydrous citric acid, sodium citrate, microcrystalline cellulose-carboxymethyl cellulose sodium and the remaining amount of sucrose into a single-column mixer for mixing, and mix evenly. A dry suspension of nitazoxanide was obtained.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a nitazoxanide pharmaceutical composition and a preparation method thereof, and belongs to the technical field of pharmacy. The nitazoxanide pharmaceutical composition comprises colloidal silicon dioxide with the mass percentage of 3-15%, and is specifically a dry suspension prepared from nitazoxanide, a flavoring agent, a suspending aid, a deflocculating agent, a coloring agent and the colloidal silicon dioxide by adopting a mixing process. The nitazoxanide pharmaceutical composition disclosed by the invention not only has relatively good flowability, but also has excellent stability; The invention also provides a simple and feasible preparation method of the nitazoxanide pharmaceutical composition.

Description

technical field [0001] The invention relates to a nitazoxanide pharmaceutical composition and a preparation method thereof, belonging to the technical field of pharmacy. Background technique [0002] Nitazoxanide was first developed by Romark Laboratories in the United States. It is an amide anti-anaerobic drug with broad-spectrum anti-protozoan worms and bacteria, especially for the treatment of cryptosporidiosis infection in AIDS patients. . ALINIA for oral suspension is the first and only drug approved by the U.S. Drug and Food Administration (FDA) for the treatment of cryptosporidiosis and the only drug licensed for the treatment of aquatic parasitic infections. [0003] The mechanism of action of nitazoxanide against protozoa and anaerobic bacteria is the direct inhibition of pyruvate ferredoxin oxidoreductase reaction. Through repeated clinical trials abroad, it has special effects on children's diarrhea caused by Cryptosporidium and Giardia lamblia, and also has the...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K31/426A61K47/04A61K9/14A61P1/00A61P1/12A61P1/16A61P31/04A61P31/12A61P31/14A61P31/20A61P33/10
CPCA61K31/426A61K9/143A61P33/10A61P31/04A61P31/20A61P31/14A61P1/16A61P1/12A61P1/00A61P31/12
Inventor 苗得足胡清文李相林吕帅杨书华刘德杰王向华
Owner REYOUNG PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap