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Method for recovering choline chloride and tartrate from choline bitartrate waste mother liquor

A technology of choline bitartrate and dicholine bitartrate, which is applied in chemical instruments and methods, separation/purification of carboxylic acid compounds, preparation of carboxylate, etc., can solve problems such as difficult recovery of choline bitartrate mother liquor, and achieve economical The benefits are considerable, the risk of environmental pollution is reduced, and the effect of eliminating waste liquid storage

Active Publication Date: 2021-08-06
济南亚西亚药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention overcomes the above-mentioned deficiencies in the prior art, and provides a method for reclaiming choline chloride and tartrate in the waste choline bitartrate mother liquor, by making dicholine bitartrate from the waste choline bitartrate mother liquor, and then dicholine bitartrate Metathesis, so as to recycle choline chloride and tartrate, solve the problem that the mother liquor of choline hydrogen bitartrate is difficult to recycle. This method has simple process, easy to obtain raw materials, considerable economic benefits, reduces the risk of environmental pollution, and eliminates waste liquid storage, Transportation safety hazard

Method used

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  • Method for recovering choline chloride and tartrate from choline bitartrate waste mother liquor
  • Method for recovering choline chloride and tartrate from choline bitartrate waste mother liquor
  • Method for recovering choline chloride and tartrate from choline bitartrate waste mother liquor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Reclaim choline chloride and calcium tartrate salt small test in embodiment 1 choline hydrogen bitartrate waste mother liquor

[0025] Table 1 Feeding ratio

[0026]

[0027] (1) Weigh 500 g of choline bitartrate waste mother liquor, the content of choline bitartrate in the mother liquor is 39.2%, and the content of dicholine bitartrate is 19.6%, pour it into a 1000ml glass reaction bottle, start stirring and heat up to 30°C for later use.

[0028] (2) take by weighing choline hydroxide aqueous solution 217g, choline hydroxide content 43%, slowly pour in the glass reaction bottle that fills choline hydrogen bitartrate waste mother liquor and carry out neutralization reaction, generate dihydrocholine bitartrate, stir After 30 minutes, measure pH8.3 for later use.

[0029] (3) Take by weighing 160g of pure water and place it in a 500ml beaker for subsequent use, take by weighing 124g of calcium chloride with a content of 94% and place it in a 500ml beaker filled with ...

Embodiment 2

[0033] Embodiment 2: Pilot test of reclaiming choline chloride and calcium tartrate in choline bitartrate waste mother liquor

[0034] Table 2 Feeding ratio

[0035]

[0036] (1) Take by weighing 30 kg of choline bitartrate waste mother liquor, in the mother liquor, the content of choline bitartrate is 41.5%, and the content of dicholine bitartrate is 20.38%, vacuumize it to a glass-lined reactor, start stirring and heat up to 30° C. for subsequent use;

[0037] (2) Take by weighing 13.80kg of choline hydroxide aqueous solution, 43% of choline hydroxide content, vacuum pump to fill in the glass-lined reactor of choline hydrogen bitartrate waste mother liquor, carry out neutralization reaction and generate dicholine bitartrate, neutralize The reaction is exothermic, the feed rate is controlled, stirred for 30 minutes, and the pH is measured to be 8.5 for later use;

[0038] (3) 10.60 kg of pure water was weighed and placed in a dissolving tank for subsequent use, and 7.83 k...

Embodiment 3

[0042] Trial production of reclaiming choline chloride and calcium salt of tartrate in embodiment 3 choline hydrogen bitartrate waste mother liquor

[0043] Feeding ratio

[0044]

[0045] (1) Take by weighing choline bitartrate waste mother liquor 1124kg, mother liquor pH value 3.8, add water 500Kg to dilute, open and stir for subsequent use;

[0046] (2) Open the trimethylamine feed valve, the initial temperature is 22°C, control the flow rate ≤ 65Kg / h, control the pressure in the kettle ≤ 0.1MPa, close the trimethylamine feed valve after feeding 110Kg of trimethylamine, measure the pH value to 7.6, and continue stirring Reacted for 30 minutes, and the end temperature was 29°C to obtain amine bitartrate;

[0047] (3) Open the ethylene oxide feed valve, the initial temperature is 29 ° C, the control flow is ≤ 30Kg / h, the pressure in the control kettle is ≤ 0.1MPa, and the ethylene oxide feed valve is closed after 88Kg of ethylene oxide is passed. The measured pH value was ...

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Abstract

The invention discloses a method for recovering choline chloride and tartrate from choline bitartrate waste mother liquor, which is characterized in that the choline bitartrate waste mother liquor is prepared into dicholine tartrate, and then the dicholine tartrate is subjected to double decomposition, so that the choline chloride and the tartrate are recovered, the problem that the choline bitartrate mother liquor is difficult to recover is solved, and the method is simple in process and low in cost. The raw materials are easy to obtain, the economic benefit is considerable and obvious, the environmental pollution risk is reduced, and potential safety hazards of waste liquid storage and transportation are eliminated.

Description

technical field [0001] The invention relates to a method for recovering choline chloride and tartrate from waste choline bitartrate mother liquor, belonging to the field of organic chemistry. Background technique [0002] Choline ([HOCH 2 CH 2 N(CH 3 ) 3 ]OH) is an unstable organic strong base (quaternary ammonium base), which is highly hygroscopic and easily soluble in water and ethanol. Choline is a component of lecithin, a precursor to acetylcholine, and is also present in sphingomyelin. Choline is widely distributed in the body and is involved in the metabolism of phospholipids, the transmission of nerve impulses, and the prevention of abnormal amounts of fat from accumulating in the liver. [0003] Choline has now become a commonly used additive in human food, and choline has been included in the list of food additives in my country, the United States, and Europe. my country's GB14880-2012 (Standards for the Use of Food Nutrition Fortifiers) specifies that the sou...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C213/00C07C213/10C07C213/04C07C215/40C07C51/41C07C51/42C07C59/255
CPCC07C213/00C07C213/10C07C213/04C07C51/412C07C51/42C07C215/40C07C59/255
Inventor 程强梅慧褚凤明马群李贤强杨秀波李秋
Owner 济南亚西亚药业有限公司
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