Preparation method of semi-interpenetrating network antibacterial gel based on natural polymers

A semi-interpenetrating network and hydrogel technology, which is applied in the field of polymer materials, can solve the problems of affecting the biocompatibility of hydrogels, limiting application promotion, and complicated preparation processes, and achieves short reaction time, wide application prospects, The effect of simple operation process

Pending Publication Date: 2021-08-06
HENAN UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the traditional azide-alkynyl Husigen cycloaddition click reaction has the advantages of strong selectivity, mild conditions, and high yield, the residual copper catalyst that is difficult to remove in the product will affect the biocompatibility of the hydrogel. Alkynyl compounds containing highly strained rings can avoid the use of copper catalysts, but their preparation process is complicated, which limits their application and promotion

Method used

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  • Preparation method of semi-interpenetrating network antibacterial gel based on natural polymers
  • Preparation method of semi-interpenetrating network antibacterial gel based on natural polymers
  • Preparation method of semi-interpenetrating network antibacterial gel based on natural polymers

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Add an appropriate amount of maleic anhydride, acrylamide, azobisisobutyronitrile and 60 mL of 1,4-dioxane in turn to a one-necked flask, stir and dissolve at room temperature, vacuumize and fill with nitrogen, circulate 3-4 times, then heat Raise the temperature to 75°C, stir and react for 8 h, then filter with suction to obtain a white solid, which is vacuum-dried at 70°C for 12 h. The total monomer concentration was controlled at 1 mol L -1 , the concentration of AIBN was controlled at 0.005 mol L -1 , By controlling the molar ratio of acrylamide and maleic anhydride, copolymers with different compositions can be obtained. Similarly, a copolymer of itaconic anhydride and acrylamide can be obtained by substituting itaconic anhydride for maleic anhydride.

Embodiment 2

[0027] Add an appropriate amount of maleic anhydride, N,N-dimethylacrylamide, azobisisobutyronitrile and 60 mL of 1,4-dioxane in turn to a one-necked flask, stir and dissolve at room temperature, vacuumize and fill with nitrogen, and circulate After 3-4 times, heat up to 75°C, stir for 8 h, cool down, precipitate with petroleum ether, and filter with suction to obtain a white solid, which is vacuum-dried at 75°C for 12 h. The total monomer concentration was controlled at 1 mol L -1 , the concentration of AIBN was controlled at 0.005 mol L -1 , By controlling the molar ratio of N,N-dimethylacrylamide to maleic anhydride, copolymers with different compositions can be obtained.

Embodiment 3

[0029] Add 6.4809 g of N-propylacrylamide, 0.8024 g of maleic anhydride, 1.7446 g of acrylamide, 0.0738 g of azobisisobutyronitrile (AIBN), and then add 60 mL of 1,4-dioxane After stirring and dissolving at room temperature, start vacuuming and nitrogen filling, stop after 3-4 cycles, start to heat up, rise to 75°C, stir and react for 8 hours, and naturally cool to room temperature, white matter precipitates, suction filtration, to get White solid, dried under vacuum at 60°C for 12 hours. A terpolymer having a molar ratio of N-isopropylacrylamide:acrylamide:maleic anhydride of 7:3:1 was obtained.

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Abstract

The invention discloses a method for preparing semi-interpenetrating network antibacterial gel based on natural polymers through click reaction of amino and anhydride in water, which comprises the following steps: firstly, modifying natural polymers such as natural products cellulose, chitosan and the like by quaternary ammonium salt to obtain a polymer with antibacterial activity; loading metal silver by using halloysite to prepare nano particles with antibacterial activity, then dissolving quaternary ammonium salt natural macromolecules, nano particles and a copolymer containing acid anhydride and amino in water to form a uniform solution, obtaining hydrogel by using a click reaction between amino and acid anhydride in water, soaking in water to remove non-crosslinked components, and freeze-drying to obtain the aerogel with antibacterial activity. The gel is rapidly generated in water, the preparation process is simple, and the obtained gel has pH responsiveness and can be used in the fields of drug sustained release, tissue engineering, water treatment and the like.

Description

technical field [0001] The invention belongs to the field of polymer materials, and relates to a method for preparing a natural polymer-based semi-interpenetrating network bacteriostatic gel by utilizing the click reaction of amino groups and acid anhydrides in water. Background technique [0002] Due to the special properties of hydrogels, hydrogels have great application potential in water treatment, drug sustained release, agriculture and other fields. Among them, smart hydrogels that can respond to environmental stimuli (temperature, pH, electric field, magnetic field, etc.) are particularly attractive. Since pH is a ubiquitous environmental change in organisms and in nature, it is of great significance to study pH-sensitive smart hydrogels. According to the different structures of hydrogels, hydrogels can be divided into single-network hydrogels, semi-IPN hydrogels and fully-IPN hydrogels. Among them, the semi-interpenetrating network hydrogel is composed of one or mo...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08J9/28C08L33/26C08L33/24C08L1/28C08L5/08C08L39/00C08K9/12C08K3/28C08K7/26
CPCC08J3/075C08J9/28C08J2333/26C08J2333/24C08J2401/28C08J2405/08C08J2439/00C08K9/12C08K3/28C08K7/26C08K2201/011C08J2201/0484C08J2205/026
Inventor 魏宏亮刘玉华胡春旺
Owner HENAN UNIVERSITY OF TECHNOLOGY
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