High-sensitivity microwave biosensor for testing saccharomycetes and application thereof

A biosensor and high-sensitivity technology, applied in the field of biosensors, can solve problems such as complex and cumbersome operations, low detection sensitivity, and long detection time, and achieve the effects of reducing costs, improving sensitivity and accuracy, and saving detection time

Active Publication Date: 2021-08-06
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] For this reason, the technical problem to be solved by the present invention is to overcome the defects of complex and cumbersome operation, long detection time and low detection sensitivity in the prior art.

Method used

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  • High-sensitivity microwave biosensor for testing saccharomycetes and application thereof
  • High-sensitivity microwave biosensor for testing saccharomycetes and application thereof
  • High-sensitivity microwave biosensor for testing saccharomycetes and application thereof

Examples

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Embodiment 1

[0027] The following introduces Embodiment 1 of a high-sensitivity microwave biosensor for yeast testing provided by the present invention, see Figure 1 to Figure 3 , embodiment one includes:

[0028] See Figure 1 to Figure 3 As shown, a high-sensitivity microwave biosensor for yeast testing includes a first substrate 100 and a second substrate 200 stacked in sequence, the first substrate 100 is provided with a microfluidic channel, and the second substrate 200 is provided with a microwave resonator.

[0029] The microfluidic channel includes a cavity 110, and the cavity 110 is used to accommodate a quantitative amount of the solution to be tested.

[0030] The microwave resonator includes a metal capacitor structure 210 and a metal inductance structure 220, the metal capacitor structure 210 includes a cascaded interdigitated capacitor, the metal inductive structure 220 includes a serpentine inductor, and the cascaded interdigitated capacitor and the serpentine inductor are...

Embodiment 2

[0043] The second embodiment of a high-sensitivity microwave biosensor for yeast testing provided by the present invention is introduced below. The second embodiment is realized based on the first embodiment above, and is expanded to a certain extent on the basis of the first embodiment.

[0044] In this embodiment, the microwave resonator proposed in the present invention is composed of a meandering inductor and two cascaded interdigitated capacitors connected in parallel. The meandering inductor has 10 coils of metal wires and 20 corners in total. The equivalent The circuit can provide more accurate equivalent circuit modeling for the subsequent structural analysis of the resonator. The operating frequency of the microwave resonator can be determined by the following equation:

[0045]

[0046] Among them, L and C represent the inductance value of the meandering inductor and the capacitance value of the cascaded interdigitated capacitor respectively. The selection of the ...

Embodiment 3

[0051] The third application example of a high-sensitivity microwave biosensor for yeast testing provided by the present invention is introduced below. The third example is implemented based on the first example above, and is expanded to a certain extent on the basis of the first example.

[0052] This embodiment provides the application of a high-sensitivity microwave biosensor for yeast testing in the detection of yeast solution. The electromagnetic flux of the microwave resonator has the ability to interact with the yeast solution to be tested: biological solutions containing different amounts of yeast exhibit different dielectric properties, and the difference in dielectric properties will cause the electromagnetic flux of the microwave resonator to generate Different changes cause the resonant frequency of the microwave resonator to shift, and the relationship between the resonant frequency shift and different amounts of yeast solutions is used to characterize the biosensi...

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Abstract

The invention relates to a high-sensitivity microwave biosensor for testing saccharomycetes. The high-sensitivity microwave biosensor comprises a first substrate and a second substrate which are stacked, the first substrate is provided with a microfluid channel, the microfluid channel comprises a cavity, and the cavity is used for containing quantitative to-be-detected solution; and the second substrate is provided with a microwave resonator, the microwave resonator comprises a metal capacitor structure and a metal inductor structure, the metal capacitor structure comprises a cascade type interdigital capacitor, the metal inductor structure comprises a winding type inductor, the cascade type interdigital capacitor is connected with the winding type inductor in parallel, and the cascade type interdigital capacitor and the cavity are calibrated and bonded. The cascade interdigital capacitor and the winding inductor are connected in parallel, so that the quality factor of the device is greatly improved, the chip size of the device is reduced, the detection sensitivity and accuracy of the device are remarkably improved, trace quantitative detection is realized, the cost of a test solution is greatly reduced, the whole detection operation is convenient and rapid, the detection time is saved, and commercialized popularization and application of the cell counting method are facilitated.

Description

technical field [0001] The invention relates to the technical field of biosensors, in particular to a high-sensitivity microwave biosensor for yeast testing and its application. Background technique [0002] Yeast is a single-celled eukaryotic microorganism, which is relatively large and belongs to the fungus class of higher microorganisms. The cell width (diameter) is about 2-6 μm, and the length is 5-30 μm. Yeast is closely related to human beings and is the most widely used type of microorganisms, occupying an important position in brewing, food, and pharmaceutical industries. It is one of the important indicators to evaluate food hygiene to monitor whether the food and its raw materials have a large number of fungal growth or mildew through the number of yeast. Yeast can make dough, protect the liver, loosen products, improve flavor, and increase nutrition, so measuring the number of yeast is of great significance. [0003] There are currently two methods for detecting...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N22/00G01N15/10
CPCG01N22/00G01N15/10G01N2015/1006
Inventor 强天马杨川高敏佳雷玉双
Owner JIANGNAN UNIV
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