Application of compound and analogue thereof as ROR gamma regulator

A technology of compounds and analogs, applied in the field of medicine, can solve the problems of unclear target signaling pathways, difficult to distinguish beneficial and harmful components of active monomers, affecting development and use, etc.
CN113264973AInactive Publication Date: 2021-08-17XIAMEN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
XIAMEN UNIV
Publication Date
2021-08-17
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses application of a compound and an analogue thereof as an ROR gamma regulator, and relates to the technical field of medicines. The compound is panaxadiol and analogues thereof, and the analogues comprise panaxatriol, protopanaxadiol, protopanaxatriol and a newly synthesized analogue. The newly synthesized analogue is a novel panoxadiol analogue which is designed and synthesized on the basis of a combination mode of panoxadiol and an ROR gamma three-dimensional crystal structure. The compound can be applied to preparation of drugs for treating or preventing diseases related to ROR gamma regulation. The compound can be applied to preparation of drugs for treating or preventing interleukin 17 regulation related diseases. The invention also discloses application of the compound or the pharmaceutically acceptable salt thereof in preparation of a pharmaceutical preparation for preventing or treating and regulating ROR gamma related diseases. The invention also relates to application of the compound in preparation of pharmaceutical compositions used in combination with other pharmaceutical preparations for preventing or treating and regulating ROR gamma-related diseases.
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Description

technical field

[0001] The invention relates to the technical field of medicine, in particular to the application of Panaxadiol and its analogs as retinoic acid receptor-related orphan receptor RORγ regulators. Background technique

[0002] The therapeutic effect of compound drugs can be exerted by binding to one or more protein "targets", thereby activating or inhibiting them to regulate the function and signal transduction of these "targets". Thus, the identification of a drug's protein target provides the basis for understanding the action of a drug's action. The elucidation of the role of these drug target proteins will provide theoretical support for the effective treatment of diseases and an effective means for the development of important new drugs.

[0003] Nuclear receptors are a group of transcription factor proteins regulated by small molecule ligands. Ligands Small molecule compounds play an important role in modulating the activity of nuclear receptors. Induc...

Claims

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