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Preparation method and application of novel adhesive antibacterial temperature-tolerant functional hydrogel

A functional water and hydrogel technology, applied in bandages, medical science and other directions, can solve the problems of sticking wounds, easy infection, easy scabs, etc., and achieve the effects of lasting antibacterial properties, avoiding secondary damage and easy preservation.

Inactive Publication Date: 2021-08-20
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional diabetic foot wound dressings are mainly dry dressings such as electrospun fibers, absorbent cotton, natural or synthetic gauze (bandages), which have problems such as sticky wounds, slow healing, susceptibility to infection, and easy scabbing.

Method used

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  • Preparation method and application of novel adhesive antibacterial temperature-tolerant functional hydrogel
  • Preparation method and application of novel adhesive antibacterial temperature-tolerant functional hydrogel
  • Preparation method and application of novel adhesive antibacterial temperature-tolerant functional hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] (1) Add 1.0 g of gelatin to a round bottom flask containing 20 mL of deionized water / glycerol (volume ratio 7:3) mixed solution, stir continuously at 60°C for half an hour, after the gelatin is completely dissolved, slowly add 2.0 g of polylysine (ε-PL, molecular weight 4000–4300 kDa), stirring was continued for 20 minutes. After cooling to room temperature, 6.0 g of acrylamide (AM) monomer, 6.0 mg of N,N'-methylenebisacrylamide (MBA) and 120.0 mg of ammonium persulfate (APS) were added in sequence, and stirred evenly. Then the obtained mixed solution was poured into a mold and reacted at 60°C for 5 h to form a semi-penetrating network hydrogel.

[0020] (2) Put the above hydrogel in a refrigerator at 4° C. for 60 minutes to react to form the final multifunctional double network hydrogel.

Embodiment 2

[0022] (1) Add 1.0 mL of gelatin to a round bottom flask containing 20 mL of deionized water / glycerin (volume ratio 4:1) mixed solution, and stir continuously at 60°C for half an hour. After the gelatin is completely dissolved, slowly add 2.0g quaternary ammonium chitosan, continue to stir for 20 minutes. After cooling to room temperature, 6.0 g of acrylamide (AM) monomer, 6.0 mg of N,N'-methylenebisacrylamide (MBA) and 120.0 mg of ammonium persulfate (APS) were added in sequence, and stirred evenly. Then the obtained mixed solution was poured into a mold and reacted at 60°C for 5 h to form a semi-penetrating network hydrogel.

[0023] (2) Put the above hydrogel in a refrigerator at 4° C. for 60 minutes to react to form the final multifunctional double network hydrogel.

Embodiment 3

[0025] (1) Add 1.0 mL of gelatin to a round bottom flask containing 20 mL of deionized water / glycerin (volume ratio 4:1) mixed solution, and stir continuously at 60°C for half an hour. After the gelatin is completely dissolved, slowly add 2.0 g of polyhexamethyleneguanidine hydrochloride, and continue stirring for 20 minutes. After cooling to room temperature, 6.0 g of acrylamide (AM) monomer, 6.0 mg of N,N'-methylenebisacrylamide (MBA) and 120.0 mg of ammonium persulfate (APS) were added in sequence, and stirred evenly. Then the obtained mixed solution was poured into a mold and reacted at 60°C for 5 h to form a semi-penetrating network hydrogel.

[0026] (2) Put the above hydrogel in a refrigerator at 4° C. for 60 minutes to react to form the final multifunctional double network hydrogel.

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Abstract

The invention provides a preparation method and application of novel adhesive antibacterial temperature-tolerant functional hydrogel. The multifunctional hydrogel is prepared by reacting antibacterial macromolecules with gelatin and acrylamide, has excellent adhesion and mechanical properties, has lasting antibacterial property for more than 7 days, keeps various excellent properties in a relatively wide temperature range (-20 DEG C to 60 DEG C), particularly has antibacterial property in a wide temperature range, and can preserve moisture for a long time. The novel adhesive antibacterial temperature-tolerant functional hydrogel is used for dressing of acute / chronic wounds and tissue regeneration auxiliary materials in different environments.

Description

technical field [0001] The invention belongs to the technical field of polymer materials, and in particular relates to the preparation of a novel adhesive, antibacterial and temperature-resistant functional hydrogel and its application in diabetic foot wound dressing. Background technique [0002] Diabetic foot is one of the most common complications in diabetic patients, which increases patients' risk of morbidity, infection, non-traumatic amputation, and even early death. Due to the high-sugar wound environment, diabetic foot has become a chronic wound disease easily infected by bacteria, which seriously affects the physical and mental health of patients and also brings a heavy social and economic burden. In clinical treatment, wound dressing has gradually become the main strategy to promote diabetic foot wound repair. Traditional diabetic foot wound dressings are mainly dry dressings such as electrospun fibers, absorbent cotton, natural or synthetic gauze (bandages), whi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00C08F289/00C08F283/04C08F251/00C08F283/00C08F220/56C08F222/38
CPCA61L26/008A61L26/0066A61L26/0038A61L26/0014A61L26/0023A61L26/0019C08F289/00C08F283/04C08F251/00C08F283/00A61L26/0085A61L2300/236A61L2300/252A61L2300/206A61L2300/404A61L2300/412C08F220/56C08F222/385C08L51/00C08L51/02C08L51/08
Inventor 林权刘厚赵月冯钰斌杨柏
Owner JILIN UNIV
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