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Wound dressing capable of rapidly absorbing heat as well as preparation method and application of wound dressing

A wound dressing, fast technology, applied in the directions of pharmaceutical formulations, bandages, drug delivery, etc., can solve the problems of poor dispersibility, poor biocompatibility of carbon-based materials, etc., and achieve easy access, good fit effect, and enhanced water absorption. sexual effect

Active Publication Date: 2021-08-24
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Carbon-based materials (graphite, graphene, graphite nanosheets, graphite fibers, and carbon nanotubes) are used in energy, In the fields of electrochemistry and composite materials, there is great potential to be applied to thermally conductive wound materials. However, the poor biocompatibility and poor dispersion of carbon-based materials in water limit their application in the field of biomaterials.

Method used

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  • Wound dressing capable of rapidly absorbing heat as well as preparation method and application of wound dressing
  • Wound dressing capable of rapidly absorbing heat as well as preparation method and application of wound dressing
  • Wound dressing capable of rapidly absorbing heat as well as preparation method and application of wound dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] A kind of hydrophilic hydrogel, preparation method is as follows:

[0045] 1. Prepare the first solution, dissolve 10.0g PEGDA in 90.0g SDS aqueous solution at room temperature and normal pressure, and stir evenly to obtain the first solution.

[0046] 2. At room temperature and normal pressure, add 0.1 g of KPS, and dissolve by ultrasonication for 10 minutes. Then 4.0 mL of 2.5 wt.% TEMED aqueous solution was added, and stirring was continued for 10 minutes.

[0047] 3. Seal the gelling solution described in step 2, and let it stand at room temperature and normal pressure for 12 hours to react to prepare a hydrophilic hydrogel.

Embodiment 2

[0049] A temperature-sensitive hydrophilic hydrogel, the preparation method of which is as follows:

[0050] 1. Prepare the first solution, dissolve 0.3g PEGDA in 2.7g SDS aqueous solution at room temperature and normal pressure, and stir evenly to obtain the first solution.

[0051] 2. Configure the second solution, mix 9.7g OEGMA, MEO 2 MA was dissolved in 87.3 g of SDS aqueous solution and stirred evenly to obtain the second solution.

[0052] 3. At room temperature and normal pressure, mix the first solution and the second solution described in step 1 and step 2 evenly, add 0.1 g of KPS, and ultrasonically dissolve for 10 minutes. Then 4.0 mL of 2.5 wt.% TEMED aqueous solution was added, and stirring was continued for 10 minutes.

[0053] 4. Seal the gel-forming solution described in step 3, and let it stand for reaction at room temperature and normal pressure for 12 hours to prepare a temperature-sensitive hydrophilic hydrogel.

Embodiment 3

[0055] A wound dressing capable of rapidly absorbing heat, the preparation method of which is as follows:

[0056] 1. Prepare the first solution, dissolve 0.3g PEGDA in 2.7g SDS aqueous solution at room temperature and normal pressure, and stir evenly to obtain the first solution.

[0057] 2. Configure the second solution, mix 9.2g OEGMA, MEO 2 MA was dissolved in 82.8 g of SDS aqueous solution and stirred evenly to obtain the second solution.

[0058] 3. Prepare the third solution, blend and dissolve 0.5g CNT-OH and 0.5g SDS in 4.0g aqueous solution at room temperature and normal pressure, and ultrasonically disperse for 30 to 120 minutes.

[0059] 4. At room temperature and normal pressure, mix the three solutions described in the above steps, stir evenly, add KPS 0.1 g, and ultrasonically dissolve for 10 minutes. Then 4.0 mL of 2.5 wt.% TEMED aqueous solution was added, and stirring was continued for 10 minutes.

[0060] 5. Seal the gelling solution described in step 4, ...

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Abstract

The invention discloses a wound dressing capable of rapidly absorbing heat, which comprises the following main components: a mixed solution of polyethylene glycol methyl ether methacrylate and 2-methyl-2-acrylic acid-2-(2-methoxyethoxy) ethyl ester, polyethylene glycol dimethyl acrylate, sodium dodecyl sulfate, potassium persulfate, hydroxylated carbon nanotubes and deionized water. The wound dressing capable of rapidly absorbing heat is prepared by the following method: ultrasonically dispersing a certain amount of hydroxylated carbon nanotubes in an aqueous solution of polyethylene glycol methyl ether methacrylate and 2-methyl-2-acrylic acid-2-(2-methoxyethoxy) ethyl ester, and performing crosslinking by using a small amount of cross-linking agent polyethylene glycol dimethacrylate; and adopting an in-situ free radical polymerization'one-pot method ' to obtain the wound dressing. The wound dressing capable of rapidly absorbing heat has the functions of rapidly absorbing heat, relieving heat injury and improving treatment comfort, and has practical application value in burn and scald treatment, laser treatment or emergency treatment.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a wound dressing capable of rapidly absorbing heat, a preparation method and application thereof. Background technique [0002] Burns are a serious public health problem with high morbidity and mortality worldwide. Burn wounds, if left untreated, can hinder wound healing and further lead to bacteremia, sepsis or multiple organ failure syndrome. Most burn patients can regain a good quality of life after effective and timely treatment, so effective wound management is particularly important in the treatment of burns and scalds. As one of the common measures to treat burns and scalds, wound dressings can effectively isolate the external environment, avoid wound infection, provide a moist environment for the wound, promote wound healing or relieve pain in a short period of time. [0003] At the same time, cooling the wound and reducing thermal damage can prevent furt...

Claims

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Application Information

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IPC IPC(8): A61L26/00C08F220/28C08F222/20
CPCA61L26/008A61L26/0061A61L26/0004A61L26/0019C08F220/286C08F220/282A61L2400/12C08L71/02C08F222/1063
Inventor 赵伟锋施文斌程荟潼王艺霖赵长生
Owner SICHUAN UNIV
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