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Quercetin tellurium nanoparticle and preparation method thereof

A quercetin and tellurium nanotechnology, applied in the field of medicine, can solve the problems of reduced biocompatibility, low photothermal conversion efficiency, poor photothermal stability, etc., to achieve reduced tolerance, high photothermal conversion efficiency, Effects that take less time

Active Publication Date: 2021-08-27
CHONGQING MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Some reported photothermal agents have the disadvantages of poor photothermal stability and low photothermal conversion efficiency, while inorganic nanoparticles have high photothermal absorption coefficient in the near infrared, and the preparation method is simple and the shape can be controlled. Wide range of applications, such as noble metal nanoparticles, carbon nanomaterials and semiconductor nanoparticles, etc.
However, it is easy to introduce toxic ligands during the preparation process of inorganic nanoparticles, which reduces the biocompatibility and limits the application.

Method used

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  • Quercetin tellurium nanoparticle and preparation method thereof
  • Quercetin tellurium nanoparticle and preparation method thereof
  • Quercetin tellurium nanoparticle and preparation method thereof

Examples

Experimental program
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Embodiment 1

[0024] The present embodiment is the preparation method of quercetin tellurium nanoparticles, comprising the following steps:

[0025] (1) Disperse 22.67 mg of quercetin in 5 mL of water, and add 0.2 mL of 1 mol / L sodium hydroxide solution under stirring conditions to form a quercetin mixture.

[0026] (2) Dissolve 4.43 mg of sodium tellurite in 1 mL of water, add it to the quercetin mixture obtained in step (1), then add 0.4 mL of 0.1 mol / L sodium borohydride solution, heat up to 37 ° C, Stir and react in the dark for 1 h, centrifuge and wash to obtain quercetin tellurium nanoparticles.

Embodiment 2

[0028] The present embodiment is the preparation method of quercetin tellurium nanoparticles, comprising the following steps:

[0029] (1) Disperse 22.67 mg of quercetin in 5 mL of water, and add 0.2 mL of 1 mol / L sodium hydroxide solution under stirring conditions to form a quercetin mixture.

[0030] (2) Dissolve 4.43 mg of sodium tellurite in 1 mL of water, add it to the quercetin mixture obtained in step (1), then add 0.4 mL of 0.1 mol / L sodium borohydride solution, heat up to 37 ° C, Stir and react in the dark for 4 hours, and centrifuge and wash to obtain quercetin tellurium nanoparticles.

Embodiment 3

[0032] The present embodiment is the preparation method of quercetin tellurium nanoparticles, comprising the following steps:

[0033] (1) Disperse 22.67 mg of quercetin in 5 mL of water, and add 0.2 mL of 1 mol / L sodium hydroxide solution under stirring conditions to form a quercetin mixture.

[0034] (2) Dissolve 4.43 mg of sodium tellurite in 1 mL of water, add it to the quercetin mixture obtained in step (1), then add 0.4 mL of 0.1 mol / L sodium borohydride solution, heat up to 55 ° C, Stir and react in the dark for 1 h, centrifuge and wash to obtain quercetin tellurium nanoparticles.

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Abstract

The invention discloses a quercetin tellurium nanoparticle and a preparation method thereof. On one hand, the quercetin tellurium nanoparticle which is appropriate in particle size distribution and has high biocompatibility, photo-thermal stability and photo-thermal conversion efficiency is constructed through simple one-step synthesis, and the preparation method is simple, short in consumed time and good in reproducibility; and on the other hand, the expression of heat shock protein is inhibited through quercetin, tolerance of tumor cells to photothermal therapy is reduced, a good treatment effect is achieved through a mild photothermal effect, and side effects of high temperature generated by the photothermal effect to normal cells are avoided. Therefore, the quercetin tellurium nanoparticle constructed by the method is expected to meet the requirement of integration of mild photo-thermal therapy and chemotherapy, the treatment effect on tumor cells is improved, and the application of the nanoparticle in the field of photo-thermal therapy is greatly enhanced.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to quercetin tellurium nanoparticles and a preparation method thereof. Background technique [0002] At present, malignant tumors have become the number one killer that endangers human health. The traditional clinical treatment methods for tumors mainly include surgical resection, radiotherapy and chemotherapy, but there are high risks of surgery, large adverse reactions of radiotherapy and chemotherapy, and multi-drug resistance. Due to the nature of the medicine and the risk of increasing the incidence of second tumors, the treatment effect is often not satisfactory. Photothermal therapy is an emerging treatment technology that concentrates photothermal agents on tumor sites, excites them with near-infrared light, converts light energy into heat, causes local overheating, and eventually kills tumor cells or indirectly causes tumor cell apoptosis. [0003] There are m...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K31/352A61P35/00B82Y5/00
CPCA61K41/0052A61K31/352A61P35/00B82Y5/00A61K2300/00
Inventor 张良珂黄旭梅
Owner CHONGQING MEDICAL UNIVERSITY
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