Self-temperature-control photothermal effect microsphere and preparation method thereof

A technology of photothermal effect and self-controlling temperature, applied in the field of medical materials, which can solve problems such as difficulty in realization

Inactive Publication Date: 2021-09-03
上海玮沐医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For interventional devices, such as coils, embolic microspheres, liquid embolic agents, etc., it is difficult to...

Method used

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  • Self-temperature-control photothermal effect microsphere and preparation method thereof

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preparation example Construction

[0037] The present invention does not specifically limit the preparation method of the hydrogel intermediate. In one embodiment, the preparation method of the hydrogel intermediate includes: adding polyhydric alcohol to water, mixing at 90-100°C, and cooling to Below 25°C, add acrylamide dialkoxyalkyl acetal and mix, add hydrochloric acid dropwise, react for 6-7 hours, wash and dry to obtain the hydrogel intermediate.

[0038] The hydrochloric acid is 36-38wt% hydrogen chloride aqueous solution, which is used as a catalyst to promote the reaction between polyol and acrylamide dialkoxyalkyl acetal. In one embodiment, the hydrochloric acid accounts for 30-60wt% of the polyol.

[0039] More preferably, the anionic crosslinking agent of the present invention is selected from 2-acrylamide-2-methylpropane carboxylate, 2-acrylamide-2-methylpropane sulfonate, allyl sulfonate, 1 - one or more of the sodium salts of propenyloxy-2-hydroxypropanesulfonic acid. The anionic crosslinking ag...

Embodiment 1

[0058] Such as figure 1 As shown, this example provides a kind of microsphere, and described microsphere comprises core layer and shell layer from inside to outside, and the preparation raw material of described core layer comprises hydrogel intermediate, anionic cross-linking agent and nanoparticle, weight ratio 85:5:10, the preparation raw materials of the core layer also include sodium persulfate, tetramethylethylenediamine and cellulose acetate, and the sodium persulfate, tetramethylethylenediamine and cellulose acetate account for water respectively The weight ratio of the total weight of the gel intermediate, nanoparticles and anionic crosslinking agent is 3:100, 2:100, 4:100; the raw materials for the preparation of the shell include hydrogel intermediate, tungsten-doped vanadium dioxide and anionic crosslinking agent, the weight ratio is 85:5:10, the preparation raw materials of the core layer also include sodium persulfate, tetramethylethylenediamine and cellulose ace...

Embodiment 2

[0067] Such as figure 1 As shown, this example provides a kind of microsphere, and described microsphere comprises core layer and shell layer from inside to outside, and the preparation raw material of described core layer comprises hydrogel intermediate, anionic cross-linking agent and nanoparticle, weight ratio 75:7:18, the preparation raw materials of the core layer also include potassium persulfate, tetramethylethylenediamine and cellulose acetate, and the potassium persulfate, tetramethylethylenediamine and cellulose acetate account for water respectively The weight ratio of the total weight of the gel intermediate, nanoparticles and anionic crosslinking agent is 5:100, 4:100, 4:100; the raw materials for the preparation of the shell include hydrogel intermediate, tungsten doped vanadium dioxide and anionic cross-linking agent, the weight ratio is 75:7:18, the preparation raw materials of the core layer also include potassium persulfate, tetramethylethylenediamine and cel...

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Abstract

The invention relates to the field of medical materials, in particular to a self-temperature-control photothermal effect microsphere and a preparation method thereof. The self-temperature-control photothermal effect microsphere comprises a core layer and a shell layer from inside to outside, the shell layer adopts a tungsten-doped vanadium dioxide/hydrogel intermediate and coats a core body structure of nano-particles with a photothermal effect, the self-control thermal therapy microsphere is obtained by utilizing the influence of W doping on the phase change temperature of the vanadium dioxide nano-particles, and the local temperature of a focus can be accurately controlled through photothermal conversion. According to the self-temperature-control photothermal effect microsphere, the W doped vanadium dioxide nanoparticles are added into the shell layer, the temperature of the microspheres is regulated and controlled through the phase change temperature, and when the doping amount of tungsten is 1.5%-1.85%, the temperature can be controlled at 40-55 DEG C. By controlling the dosage and the type of the hydrogel intermediate, the anionic cross-linking agent and the nanoparticles or the tungsten-doped vanadium dioxide nanoparticles in the core layer and the shell layer, the obtained microspheres have good elasticity and drug loading property.

Description

technical field [0001] The invention relates to the field of medical materials, more specifically, the invention relates to a self-controlling temperature photothermal effect microsphere and a preparation method thereof. Background technique [0002] There are nearly one million new patients with liver cancer every year in the world, of which China accounts for +55%. Liver cancer is the second most common cancer in China after lung cancer, and more than 400,000 surgeries are performed on liver cancer patients every year. Since liver cancer is a silent disease, it is asymptomatic in the early stage, and the course of the disease develops rapidly, so the vast majority of patients are in the middle and late stages when they are discovered. For patients with advanced liver cancer, transarterial chemoembolization (TACE) is basically required according to clinical guidelines. At first, TACE achieved the effect of embolizing tumor arteries by injecting lipiodol, and then successi...

Claims

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Application Information

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IPC IPC(8): A61L31/14A61L31/06A61L31/08A61L31/10A61L31/02A61K9/50A61K41/00A61K47/02A61K47/34A61P35/00
CPCA61L31/14A61L31/06A61L31/022A61L31/024A61L31/088A61L31/10A61K41/0052A61K9/5031A61K9/501A61P35/00A61L2300/622
Inventor 解荡
Owner 上海玮沐医疗科技有限公司
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