Self-temperature-control photothermal effect microsphere and preparation method thereof

Abstract

The invention relates to the field of medical materials, in particular to a self-temperature-control photothermal effect microsphere and a preparation method thereof. The self-temperature-control photothermal effect microsphere comprises a core layer and a shell layer from inside to outside, the shell layer adopts a tungsten-doped vanadium dioxide / hydrogel intermediate and coats a core body structure of nano-particles with a photothermal effect, the self-control thermal therapy microsphere is obtained by utilizing the influence of W doping on the phase change temperature of the vanadium dioxide nano-particles, and the local temperature of a focus can be accurately controlled through photothermal conversion. According to the self-temperature-control photothermal effect microsphere, the W doped vanadium dioxide nanoparticles are added into the shell layer, the temperature of the microspheres is regulated and controlled through the phase change temperature, and when the doping amount of tungsten is 1.5%-1.85%, the temperature can be controlled at 40-55 DEG C. By controlling the dosage and the type of the hydrogel intermediate, the anionic cross-linking agent and the nanoparticles or the tungsten-doped vanadium dioxide nanoparticles in the core layer and the shell layer, the obtained microspheres have good elasticity and drug loading property.

Description

technical field [0001] The invention relates to the field of medical materials, more specifically, the invention relates to a self-controlling temperature photothermal effect microsphere and a preparation method thereof. Background technique [0002] There are nearly one million new patients with liver cancer every year in the world, of which China accounts for +55%. Liver cancer is the second most common cancer in China after lung cancer, and more than 400,000 surgeries are performed on liver cancer patients every year. Since liver cancer is a silent disease, it is asymptomatic in the early stage, and the course of the disease develops rapidly, so the vast majority of patients are in the middle and late stages when they are discovered. For patients with advanced liver cancer, transarterial chemoembolization (TACE) is basically required according to clinical guidelines. At first, TACE achieved the effect of embolizing tumor arteries by injecting lipiodol, and then successi...

AI Technical Summary

Problems solved by technology

For interventional devices, such as coils, embolic microspheres, liquid embolic agents, etc., it is difficult to achieve thermocouple temperature control, which limits the combination of photothermal materials and medical devices.

Images