A self-controlling temperature photothermal effect microsphere and its preparation method

A photothermal effect and self-temperature control technology, which is applied in the field of medical materials, can solve problems that are difficult to achieve, and achieve the effects of avoiding agglomeration, stable properties, and smooth outer surface

Inactive Publication Date: 2022-06-28
上海玮沐医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For interventional devices, such as coils, embolic microspheres, liquid embolic agents, etc., it is difficult to achieve thermocouple temperature control, which limits the combination of photothermal materials and medical devices.

Method used

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  • A self-controlling temperature photothermal effect microsphere and its preparation method

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preparation example Construction

[0037] The present invention does not specifically limit the preparation method of the hydrogel intermediate. In one embodiment, the preparation method of the hydrogel intermediate includes: adding a polyhydric alcohol to water, mixing at 90-100° C., and then cooling to a Below 25°C, acrylamide dialkoxyalkyl acetal is added and mixed, hydrochloric acid is added dropwise, reacted for 6-7 hours, washed and dried to obtain the hydrogel intermediate.

[0038] The hydrochloric acid is a 36-38 wt% aqueous hydrogen chloride solution, which acts as a catalyst to promote the reaction between the polyol and acrylamide dialkoxyalkyl acetal. In one embodiment, the hydrochloric acid accounts for 30-60 wt% of the polyol.

[0039] More preferably, the anionic crosslinking agent of the present invention is selected from 2-acrylamido-2-methylpropane carboxylate, 2-acrylamido-2-methylpropanesulfonate, allylsulfonate, 1 - One or more of propenyloxy-2-hydroxypropanesulfonic acid sodium salt. The...

Embodiment 1

[0058] like figure 1 As shown, this example provides a microsphere, the microsphere includes a core layer and a shell layer from the inside to the outside, and the preparation raw materials of the core layer include a hydrogel intermediate, an anionic cross-linking agent and nanoparticles, and the weight ratio The ratio of 85:5:10, the preparation raw materials of the core layer also include sodium persulfate, tetramethylethylenediamine and cellulose acetate, and the sodium persulfate, tetramethylethylenediamine, and cellulose acetate occupy water respectively The weight ratio of the total weight of the gel intermediate, nanoparticles and anionic crosslinking agent is 3:100, 2:100, 4:100; the preparation raw materials of the shell layer include hydrogel intermediate, tungsten-doped vanadium dioxide and anionic crosslinking agent, the weight ratio is 85:5:10, the preparation raw materials of the core layer also include sodium persulfate, tetramethylethylenediamine and cellulose...

Embodiment 2

[0067] like figure 1 As shown, this example provides a microsphere, the microsphere includes a core layer and a shell layer from the inside to the outside, and the preparation raw materials of the core layer include a hydrogel intermediate, an anionic cross-linking agent and nanoparticles, and the weight ratio It is 75:7:18, the preparation raw materials of the core layer also include potassium persulfate, tetramethylethylenediamine and cellulose acetate, the potassium persulfate, tetramethylethylenediamine, cellulose acetate occupy water respectively The weight ratio of the total weight of the gel intermediate, nanoparticles and anionic crosslinking agent is 5:100, 4:100, 4:100; the preparation raw materials of the shell layer include hydrogel intermediate, tungsten-doped vanadium dioxide and anionic crosslinking agent, the weight ratio is 75:7:18, the preparation raw materials of the core layer also include potassium persulfate, tetramethylethylenediamine and cellulose aceta...

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Abstract

The invention relates to the field of medical materials, more specifically, the invention relates to a self-controlling temperature photothermal effect microsphere and a preparation method thereof. The microspheres include a core layer and a shell layer from the inside to the outside. The shell layer uses a tungsten-doped vanadium dioxide / hydrogel intermediate to cover the core structure of nanoparticles containing photothermal effects. Influenced by the phase transition temperature of vanadium oxide nanoparticles, self-controlling thermotherapy microspheres can be obtained, and the local temperature of the lesion can be precisely controlled through photothermal conversion. The invention adds W doping to the vanadium dioxide nanoparticles in the shell layer, and controls the temperature of the microspheres through the phase transition temperature, and when the doping amount of tungsten is 1.5-1.85%, the temperature can be controlled at 40-55°C. By controlling the dosage and types of hydrogel intermediates, anionic crosslinking agents and nanoparticles or tungsten-doped vanadium dioxide nanoparticles in the core layer and the shell layer, the obtained microspheres have good elasticity and drug-loading properties.

Description

technical field [0001] The invention relates to the field of medical materials, and more particularly, to a self-controlling temperature photothermal effect microsphere and a preparation method thereof. Background technique [0002] There are nearly one million new liver cancer patients in the world every year, of which China accounts for +55%. Liver cancer is the second largest cancer in China after lung cancer, and more than 400,000 operations are performed for liver cancer patients every year. Because liver cancer is a silent disease, asymptomatic in the early stage, and the disease course develops rapidly, the vast majority of patients are found in the middle and late stages. For patients with advanced liver cancer, transarterial chemoembolization (TACE) is basically performed according to clinical guidelines. At the earliest, TACE achieved the effect of embolizing the diseased tumor artery by injecting lipiodol, and subsequently developed gelatin sponge particles, PVA...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/14A61L31/06A61L31/08A61L31/10A61L31/02A61K9/50A61K41/00A61K47/02A61K47/34A61P35/00
CPCA61L31/14A61L31/06A61L31/022A61L31/024A61L31/088A61L31/10A61K41/0052A61K9/5031A61K9/501A61P35/00A61L2300/622
Inventor 解荡
Owner 上海玮沐医疗科技有限公司
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