A self-controlling temperature photothermal effect microsphere and its preparation method

Abstract

The invention relates to the field of medical materials, more specifically, the invention relates to a self-controlling temperature photothermal effect microsphere and a preparation method thereof. The microspheres include a core layer and a shell layer from the inside to the outside. The shell layer uses a tungsten-doped vanadium dioxide / hydrogel intermediate to cover the core structure of nanoparticles containing photothermal effects. Influenced by the phase transition temperature of vanadium oxide nanoparticles, self-controlling thermotherapy microspheres can be obtained, and the local temperature of the lesion can be precisely controlled through photothermal conversion. The invention adds W doping to the vanadium dioxide nanoparticles in the shell layer, and controls the temperature of the microspheres through the phase transition temperature, and when the doping amount of tungsten is 1.5-1.85%, the temperature can be controlled at 40-55°C. By controlling the dosage and types of hydrogel intermediates, anionic crosslinking agents and nanoparticles or tungsten-doped vanadium dioxide nanoparticles in the core layer and the shell layer, the obtained microspheres have good elasticity and drug-loading properties.

Description

technical field [0001] The invention relates to the field of medical materials, and more particularly, to a self-controlling temperature photothermal effect microsphere and a preparation method thereof. Background technique [0002] There are nearly one million new liver cancer patients in the world every year, of which China accounts for +55%. Liver cancer is the second largest cancer in China after lung cancer, and more than 400,000 operations are performed for liver cancer patients every year. Because liver cancer is a silent disease, asymptomatic in the early stage, and the disease course develops rapidly, the vast majority of patients are found in the middle and late stages. For patients with advanced liver cancer, transarterial chemoembolization (TACE) is basically performed according to clinical guidelines. At the earliest, TACE achieved the effect of embolizing the diseased tumor artery by injecting lipiodol, and subsequently developed gelatin sponge particles, PVA...

AI Technical Summary

Problems solved by technology

For interventional devices, such as coils, embolic microspheres, liquid embolic agents, etc., it is difficult to achieve thermocouple temperature control, which limits the combination of photothermal materials and medical devices.

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