Dialysis/adsorption difunctional nanofiber composite-based hemodialysis membrane and preparation method thereof

A nanofiber membrane and nanofiber technology, applied in dialysis systems, semi-permeable membrane separation, chemical instruments and methods, etc., can solve problems such as difficult liquid matrix, difficult to recycle, secondary pollution, etc., achieve good adsorption and realize scale The effect of chemical production and good permeability

Pending Publication Date: 2021-09-03
DONGHUA UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The technical problems to be solved by the present invention are: the material used to absorb toxins in hemodialysis is difficult to separate from the liquid matrix during the adsorption process, is not easy to recycle, easily causes secondary pollution, and how to realize lightweight hemodialysis and other issues

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  • Dialysis/adsorption difunctional nanofiber composite-based hemodialysis membrane and preparation method thereof
  • Dialysis/adsorption difunctional nanofiber composite-based hemodialysis membrane and preparation method thereof

Examples

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Embodiment 1

[0027] A dialysis / adsorption dual-functional nanofiber composite-based hemodialysis membrane, which sequentially includes polyvinyl alcohol hydrogel cortex and UiO-66-(COOH) 2 The nanofibers adsorb the nanoparticles to the support layer. The thickness of the polyvinyl alcohol hydrogel layer is about 0.6 μm; the thickness of the nanofiber adsorption support layer is about 100 μm, and the porosity is 75%.

[0028] The preparation steps of the dialysis / adsorption bifunctional nanofiber composite-based hemodialysis membrane include:

[0029] Step 1: Weigh 5.08g of pyromellitic acid and 4.86g of zirconium tetrachloride and dissolve them uniformly in a mixed solution of water and acetic acid, wherein water is 120mL and acetic acid is 80mL. After ultrasonication for 20 min, it was transferred to an oil bath, and heated and stirred at 100 °C for 24 h to obtain white powder UiO-66-(COOH) 2 . Finally, the resulting UiO-66-(COOH) 2 The powder was washed three times with anhydrous met...

Embodiment 2

[0034] A dialysis / adsorption dual-functional nanofiber composite-based hemodialysis membrane, which sequentially includes polyvinyl alcohol hydrogel cortex and UiO-66-(COOH) 2 The nanofibers adsorb the nanoparticles to the support layer. The thickness of the polyvinyl alcohol hydrogel layer is about 0.6 μm; the thickness of the nanofiber adsorption support layer is about 120 μm, and the porosity is 80%.

[0035] The preparation steps of the dialysis / adsorption bifunctional nanofiber composite-based hemodialysis membrane include:

[0036] Step 1: Weigh 4.06g of pyromellitic acid and 3.89g of zirconium tetrachloride and dissolve them uniformly in a mixed solution of dehydration and acetic acid, wherein water is 96mL and acetic acid is 64mL. After ultrasonication for 20 min, it was transferred to an oil bath and heated at 100 °C for 24 h to obtain white powder UiO-66-(COOH) 2 . Finally, the resulting UiO-66-(COOH) 2 The powder was washed three times with anhydrous methanol, s...

Embodiment 3

[0041] A dialysis / adsorption dual-functional nanofiber composite-based hemodialysis membrane, which sequentially includes polyvinyl alcohol hydrogel cortex and UiO-66-(COOH) 2 The nanofibers adsorb the nanoparticles to the support layer. The thickness of the polyvinyl alcohol hydrogel layer is about 0.6 μm; the thickness of the nanofiber adsorption support layer is about 150 μm, and the porosity is 80%.

[0042] The preparation steps of the dialysis / adsorption bifunctional nanofiber composite-based hemodialysis membrane include:

[0043] Step 1: Weigh 4.06g of pyromellitic acid and 3.89g of zirconium tetrachloride and dissolve them uniformly in a mixed solution of water and acetic acid, wherein water is 96mL and acetic acid is 64mL. After ultrasonication for 20 min, it was transferred to an oil bath and heated at 100 °C for 24 h to obtain white powder UiO-66-(COOH) 2 . Finally, the resulting UiO-66-(COOH) 2 The powder was washed three times with anhydrous methanol, soaked ...

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Abstract

The invention discloses a dialysis / adsorption difunctional nanofiber composite-based hemodialysis membrane and a preparation method thereof. The dialysis / adsorption difunctional nanofiber composite-based hemodialysis membrane sequentially comprises a polyvinyl alcohol hydrogel rubber layer and a nanofiber adsorption supporting layer containing UiO-66-(COOH)2 nanoparticles from top to bottom. The UiO-66-(COOH)2 nanoparticles are fixed on a nanofiber membrane with high porosity and communicated macropores, the nanofiber membrane is used as an adsorption support layer of the composite membrane, and a gel separation layer is coated on the adsorption support layer to obtain the dialysis / adsorption difunctional nanofiber composite-based hemodialysis membrane. The adsorption supporting layer achieves regeneration of dialysate by playing a toxin adsorption role, so that the use amount of the dialysate is reduced, and hemodialysis light weight is achieved. The bifunctional nanofiber composite-based hemodialysis membrane disclosed by the invention is of great significance to the development of wearable artificial kidneys.

Description

technical field [0001] The invention relates to a dialysis / adsorption dual-function nanofiber composite-based hemodialysis membrane and a preparation method thereof, belonging to the technical field of biomaterials. Background technique [0002] Kidney disease has become one of the diseases with high morbidity and mortality in human beings. About 600 million people worldwide suffer from kidney disease and it is still growing rapidly. In my country, there are nearly 120 million patients with chronic kidney disease, among which 2 million patients develop end-stage renal disease. How to effectively treat kidney diseases such as renal failure has become a research hotspot for researchers all over the world. In recent years, hemodialysis has become one of the effective treatments for patients with end-stage renal disease. Traditional hemodialysis requires patients to go to a fixed dialysis center for regular treatment, which is an intermittent treatment process and consumes a l...

Claims

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Application Information

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IPC IPC(8): B01D67/00B01D69/02B01D69/12B01D71/38B01D71/42A61M1/16
CPCB01D71/38B01D71/42B01D69/125B01D67/0002B01D69/02A61M1/16B01D2325/12
Inventor 王雪芬丁斯平李霈云张同辉
Owner DONGHUA UNIV
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