Triptolide autolytic microneedle

A technology of triptolide and self-dissolving microneedles, which is applied in the direction of microneedles, needles, organic active ingredients, etc., to achieve the effects of stable and feasible process, improved drug safety, and good mechanical strength
CN113350263AActive Publication Date: 2021-09-07GUIZHOU YANGSHENG MEDICAL INSTR
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
GUIZHOU YANGSHENG MEDICAL INSTR
Publication Date
2021-09-07

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Abstract

The invention discloses a triptolide autolytic microneedle. A prescription of a needle tip matrix of the triptolide autolytic microneedle comprises the following components of, in parts by weight, 24-29 parts of PVP (Polyvinyl Pyrrolidone), 7.8-8.3 parts of PVA (Polyvinyl Alcohol), 0.45-0.65 part of CMC-Na (Sodium Carboxymethyl Cellulose), 0.28-0.42 part of triptolide, 40-45 parts of distilled water and 20-23 parts of absolute ethyl alcohol; and a prescription of a backing layer matrix of the triptolide autolytic microneedle comprises the following components of, in parts by weight, 32-37 parts of PVP (Polyvinyl Pyrrolidone), 9-12 parts of PVA (Polyvinyl Alcohol) and 53-58 parts of distilled water. The microneedle has good microneedle formability and mechanical strength, an RSD value of a medicine loading capacity is 0.98%, a process is stable and feasible, a needle tip of a medicine-loading microneedle enables most of medicines to rapidly reach a body to take effect rapidly, and the medicine use safety of the triptolide can be improved due to a slow-release effect of a microneedle matrix; and by reducing inflammatory infiltration of cells in a synovial membrane, the expression of inflammatory factors such as TNF-alpha, IL-17, PGE2, IgG, IgM and IgA can be reduced, the expression of OPG can be increased, the expression of RANKL and an RANKL / OPG ratio can be reduced, and rheumatoid arthritis can be treated.
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Description

technical field

[0001] The invention belongs to the technical field of self-dissolving microneedles, in particular to a triptolide self-dissolving microneedle. Background technique

[0002] Triptolide (TP), one of the main components of tripterygium glycosides, is both the main active component and the toxic component. It is the main component of the current quality control standard of Tripterygium wilfordii preparations. A number of studies have found that TP has the following properties: (1) It is almost insoluble in pure water. In clinical research, it has low bioavailability, poor absorption, and it is difficult for the blood drug concentration to reach the therapeutic concentration. (2) The elimination rate in the body is fast and non-linear, and it is mainly excreted through feces, urine, and bile; (3) The lethal dose is small and the half-lives are 31 days and 204 days, respectively, and TP is in chloroform. Good stability, while alkaline media and hydrophilic solve...

Claims

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