31results about How to "The process is stable and feasible" patented technology

The invention discloses a method for preparing D-sulbenicillin sodium. The method includes steps of removing L-amino acid from L-amino acid salt of D-sulfophenylacetic acid in solvents and carrying out salt forming to obtain D-sulfophenylacetic acid salt; carrying out reaction on the D-sulfophenylacetic acid salt and acylating agents to obtain mixed acid anhydride; dissolving 6-APA in organic solvents under the effect of organic alkali; dropwise adding mixed acid anhydride solution into 6-APA solution, and carrying out sufficient reaction and after-treatment to obtain the D-sulbenicillin sodium. The D-sulfophenylacetic acid is an intermediate. The 6-APA is a matrix. The method has the advantages that the D-sulbenicillin sodium is prepared by the aid of novel synthetic routes, conditions are mild, the method includes stable process and is easy to implement, and the problems of instable processes of existing methods or insufficient optical purity of products and the like can be solved bythe aid of the method.

The invention discloses a method for extracting active components of the prescription preparation of cinnamon twigs and peony anemarrhena, which comprises the following steps: 1) taking the decoction slices of the prescription preparation of cinnamon twigs and peony anemarrhena, pulverizing and mixing; 2) adding 12-16 times Measure water for extraction, extraction time 1‑2h, extraction times 3‑4 times. The present invention uses ointment yield, cinnamon aldehyde in cassia twig, paeoniflorin in white peony, mangiferin in anemarrhena, glycyrrhizic acid in licorice and inflammatory factor IL-6 as evaluation indicators of the extraction process, and uses information entropy The weighting method was used to determine the objective weights of each index, and a comprehensive evaluation was carried out to obtain the optimal extraction process for the prescription preparation of Guizhi Paeoniae Anemarrhena. This process is stable, feasible, and repeatable. Inflammatory effect is significant, can be used for mass production.

The invention discloses a refining method and production system of sodium benzoate. The present invention uses food-grade sodium benzoate as raw material, and through dissolving, active carbon decolorization, multi-stage filtration and drying treatment, the pharmaceutical grade sodium benzoate is obtained. The process of the method of the invention is stable and feasible, accurate and controllable, and has stable quality. The purity of the obtained sodium benzoate product is ≥99.4%, and the yield of the finished product is 92-95%. In particular, the clarity, color and other indicators of the product have been greatly improved, which fully meets the pharmaceutical grade standard.

The invention discloses a traditional Chinese medicine composition for treating cancer pain and ascites, which comprises: Baiwei, Sophora flavescens, Angelica sinensis, Sanleng, Curcuma, Rhubarb, Ishijianchuan, Bombyx mori, Honeycomb and Aescin. The invention also discloses a traditional Chinese medicine plaster for treating cancer pain and ascites and a preparation method thereof. The traditional Chinese medicine plaster contains glycerin, NP-700, PVP K-90, EDTA-2Na, Chinese medicinal extract, azone, and the mass ratio It is 11:5:0.7:0.1:8:0.9. The traditional Chinese medicine composition of the present invention has the effects of clearing away heat and detoxification, promoting blood circulation and removing blood stasis, reducing swelling and relieving pain, and can be used for treating benign or malignant tumors of the lung, liver, breast, thyroid and other benign or malignant tumors and nameless swelling. Using the sticking therapy of tumor external treatment, the medicine is reconciled and applied to the affected area to exert a direct anti-tumor effect, and effectively control the cancer pain and complications of malignant tumors such as malignant pleural effusion, significantly improve the patient's symptoms, relieve suffering of patients.

The present invention relates to an epitope composition, its preparation method and use, in particular to an anti-atherosclerosis epitope composition, its preparation method and use, and belongs to the technical field of biopharmaceuticals. The epitope composition of the present invention includes 15 epitopes in M. bovis heat shock protein 65 that are characteristic of atherosclerotic autoimmune antigens. The beneficial effect is: by combining the epitopes with atherosclerotic autoimmune antigen characteristics in multiple mHSP65 molecules, the obtained epitope composition can fully exert the immune effect similar to the whole mHSP65 molecule; The epitope characteristic of atherosclerotic autoimmune antigens avoids the use of the whole molecule, reduces the impact on other autoimmune diseases, and avoids potential side effects; avoids the degradation problem caused by the protease activity of the whole mHSP65 molecule itself, making the process more stable and feasible.

The invention relates to the technical field of albendazole processing, and relates to albendazole nano-powder and a preparation method thereof. The albendazole nano-powder is combined with ball milling, high-speed shearing, high-pressure homogenization and spray drying techniques to prepare albendazole Dazol nano-powder. The present invention adopts ball milling, high-speed shearing, high-pressure homogenization combined with spray drying technology to prepare albendazole nano-micropowder, which is stable and feasible, and has good repeatability. Good dispersibility; and, compared to the albendazole raw material, the solubility and absorbability of the albendazole nano-powder of the present invention are significantly improved, that is, the albendazole nano-powder of the present invention is more suitable for making oral preparations , can be absorbed by the gastrointestinal tract, has higher bioavailability, and albendazole nano-powder has better anti-hydatid drug effect, which has laid a certain foundation for the later research and development of albendazole nano-particulate preparations.

The invention discloses a calcium dobesilate capsule and a preparation method thereof. The calcium dobesilate capsule is prepared from calcium dobesilate, croscarmellose sodium, magnesium stearate and polyvinyl pyrrolidone, wherein every 1000 calcium dobesilate capsules contain 500g of calcium dobesilate, 20-50g of croscarmellose sodium and 2-6g of magnesium stearate. In addition, a traditional preparation method is improved in the invention, and the improved method comprises the following steps: on the basis of taking the croscarmellose sodium as a disintegrating agent and taking the magnesium stearate as a lubricating agent, adding a proper amount of the polyvinyl pyrrolidone to prepare a bonding agent; preparing the bonding agent and the calcium dobesilate as well as the croscarmellose sodium into granules by a multi-step granulation method; and spraying the ethanol solution of the magnesium stearate onto the surfaces of the granules to obtain calcium dobesilate capsules with stable quality, high dissolution rate and small content uniformity.