31results about How to "The process is stable and feasible" patented technology

The invention discloses a manufacturing method of a large-calibre seamless titanium alloy barrel body, which comprises the steps of: 1, casting: casting titanium alloy raw materials into a large-calibre titanium alloy barrel blank by using a vacuum smelting furnace and through a vacuum smelting method; 2, hot isostatic pressing: performing the hot isostatic pressing for the large-bore titanium alloy barrel blank in an inert protective atmosphere by using a hot isostatic pressing device; 3, mechanical machining: processing a chamfer angle for spinning at the head of the large-bore titanium alloy barrel blank after the hot isostatic pressing by using mechanical processing equipment to obtain a spinning barrel blank; 4, spinning: thermally spinning the mechanically processed spinning barrel blank with the total deformation rate not less than 60% for many times by using spinning equipment to obtain a large-bore seamless titanium alloy thin-wall barrel body; and 5, subsequent treatment. The production process has short process flow, high yield, low cost, high utilization rate of materials and easy realization, and the defects of the large-bore seamless titanium alloy barrel body, such as complex process, high cost, low yield and the like of the traditional production process can be effectively solved.

The invention discloses a method for producing oriented electrical steel with excellent surface quality, and belongs to the technical field of oriented electrical steel production. The method comprises the following processes of: heating a casting blank at the temperature of between 1,000 and 1,190 DEG C, and then performing hot rolling; normalizing the hot rolled plate at the temperature of between 980 and 1,100 DEG C, and washing the plate by using acid; cold-rolling the plate to the thickness of a finished product under high rolling reduction rate of 86 to 93 percent; heating the cold rolled steel plate to the temperature of between 750 and 860 DEG C, and nitriding in ammonia-containing nitrogen and hydrogen mixed gas; performing decarburizing annealing at the temperature of between 800 and 860 DEG C; then coating a magnesium oxide isolation layer; raising the temperature to 1,200+ / -50 DEG C at the speed of 10 to 20 DEG C per hour in the nitrogen and hydrogen mixed gas, preserving the heat for 10 to 20 hours in hydrogen, and completing high-temperature annealing to obtain a finished product of secondary re-crystallization textures; and coating an insulating stress coating. The method has the advantage of producing the oriented electrical steel without defect on the surface and with strong adhesive force and uniform magnesium silicate bottom layer.

The invention provides a method for processing red ginseng. The method comprises the following steps of 1, slicing sun-dried ginseng; 2, performing acid steaming on the sun-dried ginsengs; and 3, drying. The extracts obtained by the method are high in content.

The invention discloses a calcium dobesilate capsule and a preparation method thereof. The calcium dobesilate capsule is prepared from calcium dobesilate, croscarmellose sodium, magnesium stearate and polyvinyl pyrrolidone, wherein every 1000 calcium dobesilate capsules contain 500g of calcium dobesilate, 20-50g of croscarmellose sodium and 2-6g of magnesium stearate. In addition, a traditional preparation method is improved in the invention, and the improved method comprises the following steps: on the basis of taking the croscarmellose sodium as a disintegrating agent and taking the magnesium stearate as a lubricating agent, adding a proper amount of the polyvinyl pyrrolidone to prepare a bonding agent; preparing the bonding agent and the calcium dobesilate as well as the croscarmellosesodium into granules by a multi-step granulation method; and spraying the ethanol solution of the magnesium stearate onto the surfaces of the granules to obtain calcium dobesilate capsules with stable quality, high dissolution rate and small content uniformity.

The invention discloses rupatadine fumarate tablets and a preparation method thereof, belonging to the technical field of medicine. The tablets are prepared by making granules from rupatadine fumarate as active ingredient, and pharmaceutical adjuvants including a filler, a binder and a disintegrant, adding a lubricant, and making into tablets. Through the screening of the type and use amount of the filler, disintegrant, binder and lubricant and the use of specific sieving mesh to sieve raw materials during a preparation process, the prepared tablets have stable properties, good content uniformity, good dissolution, small tablet weight difference and high stability, so as to ensure in vivo bioavailability and clinical curative effect.

The invention discloses a method for preparing D-sulbenicillin sodium. The method includes steps of removing L-amino acid from L-amino acid salt of D-sulfophenylacetic acid in solvents and carrying out salt forming to obtain D-sulfophenylacetic acid salt; carrying out reaction on the D-sulfophenylacetic acid salt and acylating agents to obtain mixed acid anhydride; dissolving 6-APA in organic solvents under the effect of organic alkali; dropwise adding mixed acid anhydride solution into 6-APA solution, and carrying out sufficient reaction and after-treatment to obtain the D-sulbenicillin sodium. The D-sulfophenylacetic acid is an intermediate. The 6-APA is a matrix. The method has the advantages that the D-sulbenicillin sodium is prepared by the aid of novel synthetic routes, conditions are mild, the method includes stable process and is easy to implement, and the problems of instable processes of existing methods or insufficient optical purity of products and the like can be solved bythe aid of the method.

The invention relates to a tandem type shoe cover for machine service, which comprises a plurality of bag-shaped shoe cover bodies (3) made from flexible material (1) and elastic material (2); a bag-shaped opening (4) of each shoe cover body (3) is provided with a sliding connection devices (5) matched with a material feeding guide rail and a plurality of shoe cover bodies (3) are mutually connected with each other in series orderly to form a consistent monolithic construction. The shoe cover overcomes the defects of low output, high failure rate, etc., for the prior shoe cover dispensers and is a tandem type shoe cover for machine service that is used in combination with dragging automatic shoe cover dispensers.

The invention discloses a refining method and a production system of sodium benzoate. The medicinal grade sodium benzoate is prepared by taking food grade sodium benzoate as a raw material and throughdissolution, active carbon decoloration, multi-grade filtration and drying treatment. The refining method is stable and feasible, and accurately controllable, and the quality is stable. The purity ofthe sodium benzoate product is higher than or equal to 99.4%, the product yield is higher than or equal to 92-95%, especially a plurality of indexes such as the clearness and the color of the productare dramatically improved, and the sodium benzoate completely conforms to the medicinal grade standard.

The invention discloses a traditional Chinese medicine composition for treating cancer pain and ascites. The traditional Chinese medicine composition comprises, the rhizome of vincetoxicum atratum, the dried root of sophora flavescens, the dried root of Chinese angelica, the dried tuber of sparganium, the root and stem of curcuma zedoary, the rhizome of rheum officinale, bombyx batryticatus, the beehive of polistes japonicus sauss and the rhizome of paris polyphylla. The invention further provides a traditional Chinese medicine plaster for treating cancer pain and ascites and a preparation method thereof. The traditional Chinese medicine plaster comprises glycerol, NP-700, PVP K-90, EDTA-2Na, traditional Chinese extract and azone in the mass ratio of 11:5:0.7:0.1:8:0.9. The traditional Chinese medicine composition has the effects of clearing away heat and toxic material, activating blood circulation to dissipate blood stasis and relieving swelling and pain and can be used for treatinglung, liver, breast, thyroid malignant and benign tumors and unidentifiable poisoned sores and the like. By means of the application therapy of the external treatment of tumors, medicines are in harmonious proportion and applied to affected parts to achieve a direct anti-tumor effect, and the cancer pain and the complication such as malignant pleural effusion and ascites caused by the malignant tumors are effectively controlled to significantly improve the symptoms of patients and relieve the pain of the patients.

The invention discloses a preparation method of amorphous cefditoren pivoxil. The preparation method comprises the following steps: dissolving cefditoren pivoxil crystals in an organic solvent, rapidly concentrating, obtaining a cefditoren pivoxil amorphous form, or concentrating to a small volume, dropwise adding to a second organic solvent, and precipitating the cefditoren pivoxil amorphous form. A target product is detected by an XPRD manner and is an amorphous peak type. By adopting the cefditoren pivoxil amorphous form prepared in the invention, the solubility of the cefditoren pivoxil can be improved, and the bioavailability of a drug preparation can be improved. The preparation method disclosed in the invention is mild in conditions, stable in process, easy in operation.

The invention relates to a pharmaceutical composition for chronic renal failure and a preparation method thereof. The pharmaceutical composition is prepared from deer blood crystals, poria cocos, dendrobium nobile and rhizoma atractylodis macrocephalae. The preparation method comprises the steps that the poria cocos, the rhizoma atractylodis macrocephalae and the dendrobium nobile are taken and decocted twice with water, after decoction liquid is concentrated, the deer blood crystals and auxiliary materials are added, and a preparation is prepared. The pharmaceutical composition has remarkable effects in the aspects of protecting the renal function and delaying the chronic renal failure.

The invention relates to an epitope composition, as well as a preparation method and uses thereof, in particular to an anti-atherosclerosis epitope composition, as well as a preparation method and uses thereof, which belongs to the technical field of biopharmacy. The epitope composition comprises fifteen epitopes having the characteristics of atherosclerosis autoimmune antigen in Mycobacterium bovine heat shock protein 65. The invention has the advantages that the obtained epitope composition can give full play to the immune efficacy of molecules similar to all-mHSP65 molecules by combining the epitopes having the characteristics of the atherosclerosis autoimmune antigen in a plurality of mHSP65 molecules; in addition, the epitopes having the characteristics of the atherosclerosis autoimmune antigen are chosen and the use of all-molecules is avoided, thereby reducing the influence on other autoimmune diseases, avoiding potential side effects, avoiding degradation problems brought by the own protease activity of the all-mHSP65 molecules and ensuring more stable and feasible process.

The invention discloses a refining method for preparing high-purity non-caking fine-particle citric acid crystals, wherein the refining method comprises the steps: by using a citric acid crude productas a raw material, dissolving, decolorizing, filtering, concentrating, crystallizing, separating and drying to obtain refined citric acid. The method provided by the invention is simple and easy to implement and mild in condition, and overcomes the defects that a citric acid product obtained by an existing edible citric acid production method contains more impurities and is easy to cake. The method is stable, feasible, accurate, controllable and stable in quality, the content of citric acid and the impurity removal effect are remarkably improved, the purity of the obtained citric acid productis more than or equal to 99.5%, particularly, the particle size, the chloride content, the sulfate content and the like of the product are greatly improved, and the pharmaceutical grade standard is completely met.

The invention discloses a method for extracting active ingredients of a cassia twig, Chinese peony and rhizoma anemarrhenae prescription preparation. The method comprises the following steps: 1) taking formula decoction pieces of the cassia twig, Chinese peony and rhizoma anemarrhenae prescription preparation, and performing crushing and uniform mixing; and 2), adding 12-16 times of water for extraction, wherein the extraction time is 1-2 h, and the extraction frequency is 3-4 times. The method takes the extract yield, cinnamaldehyde in cassia twigs, paeoniflorin in Chinese peony, mangiferin in rhizoma anemarrhenae, glycyrrhizic acid in liquorice roots and inflammatory factors IL-6 as evaluation indexes of an extraction process; and determines the objective weight of the indexes by adopting an information entropy weighting method, and carries out comprehensive evaluation to obtain the optimal extraction process of the cassia twig, Chinese peony and rhizoma anemarrhenae prescription preparation. The process is stable, feasible and good in repeatability. The prepared extracts are high in medicinal component content and remarkable in anti-inflammatory effect, and can be used for massproduction.

The invention provides an emulsifying technology for restoring cream. The technology comprises the following steps that 1, shea butter, olive oil, stearic acid and octadecanol are mixed, heated and stirred to obtain an oil phase ingredient; 2, water soluble raw materials are dissolved into deionized water, then, an emulsifying ingredient is added, heated and stirred to obtain a water phase mixture; 3, the water phase mixture is added into the oil phase ingredient, constant temperature emulsifying is performed, gradient cooling is performed to 35-40 DEG C, plant sterol lipidosome dry powder isadded, homogenous treatment is performed for 4-8 min, and oligopeptide-1, oligopeptide-2, dragon's blood and horse fat are subjected to homogenous treatment for 3-5 min. According to the emulsifying technology for restoring cream, by optimizing the oil phase raw materials, the ingredient ratio thereof, the emulsifying ingredient and the content thereof, the anti-wrinkle restoring cream containingplant sterol lipidosome with the good physical stability can be obtained, the dispersibility and biological utilizing rate of plant sterol in the repairing cream are increased, and therefore the effects of resisting oxidation, flatting thin veins and resisting wrinkles of the restoring cream are improved.

The invention discloses a histamine dihydrochloride injection. The histamine dihydrochloride injection is prepared from histamine dihydrochloride, a PH regulator and injection water. A preparation method of the histamine dihydrochloride injection includes: dissolving and densely mixing chemicals, adsorbing a heat source with activated carbon, diluting a chemical solution and determining PH, packaging with a filter membrane, and performing disinfection, lamp detection and packaging. Shape and properties, pH value, solution clarity, color, relevant substances, content and the like of a product obtained in the invention are in accordance with stipulations of quality specifications. Addition of supplementary materials is small, concerns for safety is greatly reduced, the cost is low and the technique is stable and feasible.

The invention discloses a triptolide self-dissolving microneedle. According to the present invention in parts by weight, the tip matrix prescription of the triptolide self-dissolving microneedle is 24-29 parts of PVP, 7.8-8.3 parts of PVA, 0.45-0.65 parts of CMC-Na, 0.28-0.42 parts of triptolide 40-45 parts of distilled water and 20-23 parts of absolute ethanol; the backing layer matrix prescription of the triptolide self-dissolving microneedles is 32-37 parts of PVP, 9-12 parts of PVA and 53-58 parts of distilled water. The present invention has good moldability and mechanical strength of the microneedle, RSD value of the drug loading is 0.98%, and the process is stable and feasible. The tip of the drug-loaded microneedle can make most of the drug reach the body quickly and take effect quickly. In addition, the microneedle matrix The sustained release effect of triptolide can improve the drug safety of triptolide, and reduce the expression and increase of inflammatory factors TNF-ɑ, IL-17, PGE2, IgG, IgM, and IgA by reducing the inflammatory infiltration of cells in the synovium. The expression of OPG, the trend of decreased RANKL expression and the RANKL / OPG ratio, realize the therapeutic advantages for rheumatoid arthritis.

The invention discloses a method for preparing D-sulbenicillin sodium. The method includes steps of removing L-amino acid from L-amino acid salt of D-sulfophenylacetic acid in solvents and carrying out salt forming to obtain D-sulfophenylacetic acid salt; carrying out reaction on the D-sulfophenylacetic acid salt and acylating agents to obtain mixed acid anhydride; dissolving 6-APA in organic solvents under the effect of organic alkali; dropwise adding mixed acid anhydride solution into 6-APA solution, and carrying out sufficient reaction and after-treatment to obtain the D-sulbenicillin sodium. The D-sulfophenylacetic acid is an intermediate. The 6-APA is a matrix. The method has the advantages that the D-sulbenicillin sodium is prepared by the aid of novel synthetic routes, conditions are mild, the method includes stable process and is easy to implement, and the problems of instable processes of existing methods or insufficient optical purity of products and the like can be solved bythe aid of the method.

The invention discloses a method for extracting active components of the prescription preparation of cinnamon twigs and peony anemarrhena, which comprises the following steps: 1) taking the decoction slices of the prescription preparation of cinnamon twigs and peony anemarrhena, pulverizing and mixing; 2) adding 12-16 times Measure water for extraction, extraction time 1‑2h, extraction times 3‑4 times. The present invention uses ointment yield, cinnamon aldehyde in cassia twig, paeoniflorin in white peony, mangiferin in anemarrhena, glycyrrhizic acid in licorice and inflammatory factor IL-6 as evaluation indicators of the extraction process, and uses information entropy The weighting method was used to determine the objective weights of each index, and a comprehensive evaluation was carried out to obtain the optimal extraction process for the prescription preparation of Guizhi Paeoniae Anemarrhena. This process is stable, feasible, and repeatable. Inflammatory effect is significant, can be used for mass production.

The invention relates to a method of enriching and purifying total flavonoids of all grass of cardamine tangutorum. The method comprises the following steps: (1) preparing extract of the all grass ofcardamine tangutorum; (2) loading the extract of the all grass of cardamine tangutorum on a macroporous resin adsorption column, wherein the loading quantity is 8-48ml of the extract for each gram ofdry macroporous resin, and the flow is 3-4BV / h; after the loading, washing with water and then eluting with ethanol, wherein the volume fraction of ethanol is 10-90%, and the flow is 2-8BV / h; collecting the eluent and detecting the content of total flavonoids. The technology is stable and feasible, provides test data and scientific basis for the enrichment and purification of the total flavonoidsof the all grass of cardamine tangutorum, and lays a foundation for further studying the active chemical ingredients in the all grass of cardamine tangutorum and studying the digestion promoting function of the all grass of cardamine tangutorum.

The invention provides an emulsifying technology for restoring cream. The technology comprises the following steps that 1, shea butter, olive oil, stearic acid and octadecanol are mixed, heated and stirred to obtain an oil phase ingredient; 2, water soluble raw materials are dissolved into deionized water, then, an emulsifying ingredient is added, heated and stirred to obtain a water phase mixture; 3, the water phase mixture is added into the oil phase ingredient, constant temperature emulsifying is performed, gradient cooling is performed to 35-40 DEG C, plant sterol lipidosome dry powder isadded, homogenous treatment is performed for 4-8 min, and oligopeptide-1, oligopeptide-2, dragon's blood and horse fat are subjected to homogenous treatment for 3-5 min. According to the emulsifying technology for restoring cream, by optimizing the oil phase raw materials, the ingredient ratio thereof, the emulsifying ingredient and the content thereof, the anti-wrinkle restoring cream containingplant sterol lipidosome with the good physical stability can be obtained, the dispersibility and biological utilizing rate of plant sterol in the repairing cream are increased, and therefore the effects of resisting oxidation, flatting thin veins and resisting wrinkles of the restoring cream are improved.

The invention discloses a refining method and production system of sodium benzoate. The present invention uses food-grade sodium benzoate as raw material, and through dissolving, active carbon decolorization, multi-stage filtration and drying treatment, the pharmaceutical grade sodium benzoate is obtained. The process of the method of the invention is stable and feasible, accurate and controllable, and has stable quality. The purity of the obtained sodium benzoate product is ≥99.4%, and the yield of the finished product is 92-95%. In particular, the clarity, color and other indicators of the product have been greatly improved, which fully meets the pharmaceutical grade standard.

The invention discloses a traditional Chinese medicine composition for treating cancer pain and ascites, which comprises: Baiwei, Sophora flavescens, Angelica sinensis, Sanleng, Curcuma, Rhubarb, Ishijianchuan, Bombyx mori, Honeycomb and Aescin. The invention also discloses a traditional Chinese medicine plaster for treating cancer pain and ascites and a preparation method thereof. The traditional Chinese medicine plaster contains glycerin, NP-700, PVP K-90, EDTA-2Na, Chinese medicinal extract, azone, and the mass ratio It is 11:5:0.7:0.1:8:0.9. The traditional Chinese medicine composition of the present invention has the effects of clearing away heat and detoxification, promoting blood circulation and removing blood stasis, reducing swelling and relieving pain, and can be used for treating benign or malignant tumors of the lung, liver, breast, thyroid and other benign or malignant tumors and nameless swelling. Using the sticking therapy of tumor external treatment, the medicine is reconciled and applied to the affected area to exert a direct anti-tumor effect, and effectively control the cancer pain and complications of malignant tumors such as malignant pleural effusion, significantly improve the patient's symptoms, relieve suffering of patients.

The present invention relates to an epitope composition, its preparation method and use, in particular to an anti-atherosclerosis epitope composition, its preparation method and use, and belongs to the technical field of biopharmaceuticals. The epitope composition of the present invention includes 15 epitopes in M. bovis heat shock protein 65 that are characteristic of atherosclerotic autoimmune antigens. The beneficial effect is: by combining the epitopes with atherosclerotic autoimmune antigen characteristics in multiple mHSP65 molecules, the obtained epitope composition can fully exert the immune effect similar to the whole mHSP65 molecule; The epitope characteristic of atherosclerotic autoimmune antigens avoids the use of the whole molecule, reduces the impact on other autoimmune diseases, and avoids potential side effects; avoids the degradation problem caused by the protease activity of the whole mHSP65 molecule itself, making the process more stable and feasible.

The invention relates to the technical field of albendazole processing, and relates to albendazole nano-powder and a preparation method thereof. The albendazole nano-powder is combined with ball milling, high-speed shearing, high-pressure homogenization and spray drying techniques to prepare albendazole Dazol nano-powder. The present invention adopts ball milling, high-speed shearing, high-pressure homogenization combined with spray drying technology to prepare albendazole nano-micropowder, which is stable and feasible, and has good repeatability. Good dispersibility; and, compared to the albendazole raw material, the solubility and absorbability of the albendazole nano-powder of the present invention are significantly improved, that is, the albendazole nano-powder of the present invention is more suitable for making oral preparations , can be absorbed by the gastrointestinal tract, has higher bioavailability, and albendazole nano-powder has better anti-hydatid drug effect, which has laid a certain foundation for the later research and development of albendazole nano-particulate preparations.

The invention discloses a traditional Chinese medicine malt germination processing method. The method comprises the following steps: S1, washing raw barley to remove impurities; S2, adding sufficient water into the raw barley in the step S1, and conducting soaking for 5 hours; S3, fishing out the soaked barley malt and placing the soaked barley in a drainage container, spraying water every day under the conditions that the temperature is 25 DEG C and the humidity is 70% to keep the barley malt moist, and stopping sprouting when the barley sprouts to the length of 0.5 cm, wherein the mass ratio of the water spraying amount every day to the barley malt is 1:1; and S4, drying the germinated barley at 70 DEG C under normal pressure for 12 hours, wherein the water content of the dried barley malt is 2.07%. In order to solve the problem that specific parameters are not provided in an existing barley germination process, the invention provides a better implementation method for germination processing of traditional Chinese medicine malt, the process is stable and feasible, the drug property of the malt is guaranteed, and the practicability is very good.

The present invention discloses a Preparing method of Cefsulodin, comprising the steps of Intermediate D-alpha-Sulfophenylacetic acid or its salt with acylating agent to form mixed acid anhydride; Key intermediate 7-PACA dissolved in the solvent in the organic base or inorganic base under the a certain temperature to get 7-PACA solution; dropping mixed acid anhydride solution into 7- PACA solution, and to obtain the Cefsulodin after full reaction and treatment. The method adopts the new synthetic method to carry out the 7-position condensation reaction with the mixed acid anhydride method. The new method has mild condition, stable process and easy operation, which is helpful in solving unstable process problems caused by hard production of Sulfophenylacetyl chloride, unstable Acyl chloride, or the instability of the intermediate in the subsequent reaction.

The invention relates to a new process of amino G acid ammonification production, belonging to the field of organic chemistry. In the new process provided by the invention, the finished product of amino G acid is prepared by taking ammonium bicarbonate as an aminolysis agent by the steps such as dosing, low-temperature ammonification and high-temperature high-pressure ammonification; the yield of amino G acid is increased to over 90% from 82% before, and the product purity is improved by 2%. Meanwhile, by adopting the process, the pressure maintained by an ammonification reaction kettle is reduced from 1.2MPa to 0.5MPa, and the process has the characteristics of high safety coefficient and stability.

The invention discloses a calcium dobesilate capsule and a preparation method thereof. The calcium dobesilate capsule is prepared from calcium dobesilate, croscarmellose sodium, magnesium stearate and polyvinyl pyrrolidone, wherein every 1000 calcium dobesilate capsules contain 500g of calcium dobesilate, 20-50g of croscarmellose sodium and 2-6g of magnesium stearate. In addition, a traditional preparation method is improved in the invention, and the improved method comprises the following steps: on the basis of taking the croscarmellose sodium as a disintegrating agent and taking the magnesium stearate as a lubricating agent, adding a proper amount of the polyvinyl pyrrolidone to prepare a bonding agent; preparing the bonding agent and the calcium dobesilate as well as the croscarmellose sodium into granules by a multi-step granulation method; and spraying the ethanol solution of the magnesium stearate onto the surfaces of the granules to obtain calcium dobesilate capsules with stable quality, high dissolution rate and small content uniformity.

The invention discloses a preparation method of a 4-(2, 5-dibromobenzoyl) aza-aromatic ring. The method comprises the following steps: 1, performing a reaction on aza-aromatic ring formic acid with achlorinating agent according to a certain feeding ratio in a weak polar solvent system to prepare aza-aromatic ring formyl chloride hydrochloride, wherein the process has advantages of reducing the consumption of the chlorinating agent and relieving the environmental pollution caused by the chlorinating agent; and 2, carrying out a Lewis acid catalytic reaction on the aza-aromatic ring formyl chloride hydrochloride and 1,4-dibromobenzene in a certain feeding ratio at a certain temperature in a solvent-free system to obtain the 4-(2,5-dibromobenzoyl) aza-aromatic ring.