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Albendazole nanopowder and preparation method thereof

A technology of albendazole and nano-powder, which is applied in the field of albendazole nano-powder and its preparation, can solve the problems of low bioavailability and poor absorbability, and achieve high bioavailability, improved solubility and absorbability, The process is stable and feasible

Active Publication Date: 2021-04-20
THE FIRST TEACHING HOSPITAL OF XINJIANG MEDICAL UNIVERCITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The invention provides a kind of albendazole nano-powder and its preparation method, which overcomes the deficiencies of the above-mentioned prior art, and can effectively solve the problems of poor absorption and low bioavailability in the existing albendazole tablet dosage form The problem

Method used

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  • Albendazole nanopowder and preparation method thereof
  • Albendazole nanopowder and preparation method thereof
  • Albendazole nanopowder and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Embodiment 1: The albendazole nano-powder is obtained according to the following preparation method: the first step, the albendazole raw material is sieved after ball milling to obtain the albendazole ball milling raw material; the second step, the albendazole The azole ball mill raw material is mixed with an aqueous solution containing an appropriate amount of dispersant to obtain a raw material suspension of albendazole; in the third step, the raw material suspension of albendazole is subjected to high-speed shearing to obtain an initial suspension of albendazole; The fourth step is to obtain the albendazole nanosuspension after high-pressure homogenization of the albendazole initial suspension; the fifth step is to add the required amount of drying protection agent to the albendazole nanosuspension , and then dried to obtain albendazole nano-powder.

[0052] In this embodiment, the process of preparing albendazole (ABZ) nano-powder by ball milling, high-speed shearin...

Embodiment 2

[0055] Embodiment 2: As the optimization of above-mentioned embodiment, the mass ratio of albendazole raw material and dispersant is 1:2 to 4:1, and described dispersant is Tween 80, poloxamer 407, poloxamer 188, one of sodium lauryl sulfate, macrogol 1000 natural vitamin E succinate, polyethylene glycol 15-hydroxystearate, polyoxyethylene hydrogenated castor oil 40; addition of dry protection agent Add 5 grams to 20 grams of desiccation protection agent according to 100 milliliters of albendazole nanosuspension, and described desiccation protection agent is maltodextrin, mannitol, inositol, sorbitol, xylitol, lactitol, maltose Alcohol, alanine, glycine, L-histidine, lactose, sucrose, fructose, inulin, trehalose, maltose, hydroxypropyl-β-cyclodextrin.

Embodiment 3

[0056] Embodiment 3: As the optimization of the above-mentioned embodiment, the ball milling time is 4h to 12h, the ball milling temperature is less than 30°C, and the sieve is 200 mesh to 300 mesh; the albendazole in the albendazole raw material suspension The mass percentage is 0.5% to 2%; the speed of high-speed shearing is 3500r / min to 24000r / min, the shearing time is 5min to 20min, the shearing temperature is 0°C to 60°C; the temperature of high pressure homogenization is 0°C to 60°C, the pressure of high-pressure homogenization is 10000Psi to 30000Psi, and the number of high-pressure homogenization cycles is 5 to 35 times; the drying is normal pressure drying, reduced pressure drying, spray drying or freeze drying.

[0057] In this embodiment, a high-energy nano ball mill is used to ball mill the raw material of albendazole.

[0058] Compared with other drying methods (freeze drying, normal pressure drying, and reduced pressure drying), the ABZ nanopowder prepared by the...

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Abstract

The invention relates to the technical field of albendazole processing, and relates to albendazole nano-powder and a preparation method thereof. The albendazole nano-powder is combined with ball milling, high-speed shearing, high-pressure homogenization and spray drying techniques to prepare albendazole Dazol nano-powder. The present invention adopts ball milling, high-speed shearing, high-pressure homogenization combined with spray drying technology to prepare albendazole nano-micropowder, which is stable and feasible, and has good repeatability. Good dispersibility; and, compared to the albendazole raw material, the solubility and absorbability of the albendazole nano-powder of the present invention are significantly improved, that is, the albendazole nano-powder of the present invention is more suitable for making oral preparations , can be absorbed by the gastrointestinal tract, has higher bioavailability, and albendazole nano-powder has better anti-hydatid drug effect, which has laid a certain foundation for the later research and development of albendazole nano-particulate preparations.

Description

technical field [0001] The invention relates to the technical field of albendazole processing, and relates to a nano-powder of albendazole and a preparation method thereof. Background technique [0002] Hydatid disease is a zoonotic parasitic disease caused by the larvae of Echinococcus tapeworm in the human body. Human echinococcosis develops slowly and is mainly chronic consumption, which can make patients gradually lose their ability to work, significantly reduce the quality of life, and has a high mortality rate. It is the most serious parasitic disease that endangers the health of the Xinjiang region and people. [0003] Although surgery is still the first choice for treatment at this stage, the clinical effect of drug treatment can not only reduce the recurrence rate, but also improve the cure rate of surgery has been continuously affirmed. At present, the drugs used to treat echinococcosis mainly include benzoimidazole, and its representative drug albendazole is the ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/19A61K9/14A61K31/4184A61K47/40A61K47/10A61P33/10
CPCA61K9/145A61K9/146A61K9/19A61K31/4184A61P33/10
Inventor 赵军陈蓓王建华温浩高惠静巩月红张玉欣陈国儒文丽梅卢帅陈渤松
Owner THE FIRST TEACHING HOSPITAL OF XINJIANG MEDICAL UNIVERCITY
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