Unlock instant, AI-driven research and patent intelligence for your innovation.

Polysaccharide supramolecular polymer drug carrier based on host-guest interaction and preparation method thereof

A supramolecular polymer, polysaccharide technology, applied in the directions of drug combination, drug delivery, pharmaceutical formulation, etc., can solve the problems of difficult infiltration of tumor cells, separation of nano-systems, insufficient drug amount, etc., to solve the problem of tumor penetration and good stability. , the effect of not easy to decompose

Active Publication Date: 2022-03-15
SOUTHWEST UNIV
View PDF15 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, such nanosystems will face the difficulty of separating from the tumor stroma
It can only accumulate in the peritumoral area, making it difficult to infiltrate into the populated tumor cells, resulting in insufficient drug volume in solid tumors

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Polysaccharide supramolecular polymer drug carrier based on host-guest interaction and preparation method thereof
  • Polysaccharide supramolecular polymer drug carrier based on host-guest interaction and preparation method thereof
  • Polysaccharide supramolecular polymer drug carrier based on host-guest interaction and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1 Polysaccharide supramolecular polymer drug carrier based on host-guest interaction and preparation method thereof

[0028] The general synthesis schematic diagram of polysaccharide supramolecular polymer drug carrier and its preparation method based on host-guest interaction figure 1 As shown, it mainly includes the following steps:

[0029] (1) Preparation of polysaccharide polymer backbone DA, the synthetic route is shown below, including the following steps: first, the water molecules in DEX are completely removed by azeotroping with toluene, and DEX-CBA is synthesized by esterification of DEX and 4-CBA . DEX (1 g, Mn=10000, 5.6 mmol) and 4-CBA (420.36 mg, 2.8 mmol) were dissolved in 5 mL of anhydrous DMSO, and reacted under argon. Then DCC (693.27 mg, 3.36 mmol) and DMAP (30.54 mg, 0.25 mmol) dissolved in 2 mL of anhydrous DMSO were added respectively, and stirred at room temperature for 48 h. The obtained product was purified by filtration, then precip...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a polysaccharide supramolecular polymer drug carrier based on host-guest interaction and a preparation method thereof. The preparation method includes the following steps: (1) synthesizing polysaccharides from dextran (DEX) and p-carboxybenzaldehyde (4‑CBA) and polymerizing (2) polysaccharide polymer backbone DA and mono(6‑amino‑6‑deoxy)‑β‑cyclodextrin (CD‑NH 2 ) Preparation of copolymer DA‑CD; (3) Preparation of doxorubicin prodrug DA‑DOX (4) Combining DA‑CD and doxorubicin prodrug DA‑DOX through host-guest interaction between macromolecules, named DCD SNs. The obtained amphiphilic polymer prodrug can form supramolecular drug micelles in water, and has the advantages of high micelle stability, controllable micelle shape, high drug loading capacity, low toxicity and side effects, and good drug controlled release. Nanoparticles help to construct a long-circulation and deep-penetrating smart drug delivery system for highly effective antitumor therapy.

Description

technical field [0001] The invention relates to the field of macromolecule chemical drugs, in particular to a polysaccharide supramolecular polymer drug carrier based on host-guest interaction and a preparation method thereof. Background technique [0002] Cyclodextrin (CD for short) is a general term for a series of cyclic oligosaccharides produced by amylose under the action of cyclodextrin glucosyltransferase produced by Bacillus, usually containing 6-12 D-pyran glucose unit. Because the outer edge (Rim) of cyclodextrin is hydrophilic and the inner cavity (Cavity) is hydrophobic, it can provide a hydrophobic binding site like an enzyme, and act as a host (Host) to envelop various appropriate guests (Guest), such as Organic molecules, inorganic ions and gas molecules, etc. Its inner cavity is hydrophobic and the outer surface is hydrophilic, so that it can form clathrates and molecular assembly systems with many organic and inorganic molecules according to van der Waals ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/69A61K31/704A61K47/61A61P35/00
CPCA61K47/6939A61K47/6951A61K47/61A61K31/704A61P35/00
Inventor 许志刚胡峻峰梁梦云
Owner SOUTHWEST UNIV