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Magnesium-based metal polymer composite bone-guided regeneration membrane and preparation method thereof

A magnesium-based metal, guided regeneration technology, applied in the field of medical materials, dental implant filling materials and antibacterial implant materials, can solve the problems of insufficient activity of osteoconductive membrane, no antibacterial, etc.

Pending Publication Date: 2021-09-10
SHENYANG LIGONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the problem of osseointegration and infection of osteoconductive membrane, the present invention provides a magnesium-based metal-polymer composite osteoconductive regeneration membrane and its preparation method, which uses evaporation technology to prepare magnesium-based metal coating on degradable polymer materials. layer to solve the problem of lack of activity and no antibacterial properties of the existing osteoconductive membrane. The degradable regenerative membrane obtained by this method has excellent biocompatibility and biological activity and has a bactericidal function

Method used

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  • Magnesium-based metal polymer composite bone-guided regeneration membrane and preparation method thereof
  • Magnesium-based metal polymer composite bone-guided regeneration membrane and preparation method thereof
  • Magnesium-based metal polymer composite bone-guided regeneration membrane and preparation method thereof

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Embodiment 1

[0026] The polyvinyl alcohol sheet is placed in the furnace body of the deposition chamber, with a thickness of 0.5 mm, a length of 2 cm, and a width of 1 cm. Place the magnesium raw material in the evaporation chamber. The content of Cu is 0.2%, the content of Zn is 1%, the balance is Mg, and the ultimate vacuum (10 -4 Pa). Set the sublimation temperature of the magnesium-based metal to 400°C and the working pressure to 1×10 -3 Pa, the deposition temperature is 150°C, and the deposition time is 30 min. The sample is taken out after cooling with the furnace. The thickness of the magnesium-based metal coating is 100 µm. The degradation rate of the magnesium-based metal coating is higher than that of the polymer material layer, and the degradation time is about 25 days, and the polymer material layer is completely degraded for ≥10 weeks.

Embodiment 2

[0028] Place the polylactic acid sheet in the furnace body of the deposition chamber, with a thickness of 0.2 mm, a length of 4 cm, and a width of 2 cm. Put the pure magnesium raw material in the evaporation chamber. Ultimate vacuum (10 -4 Pa). Set the sublimation temperature of the magnesium-based metal to 450°C and the working pressure to 1×10 -2 Pa, the deposition temperature is 200°C, the deposition time is 60min, the sample is taken out after cooling in the furnace, the thickness of the magnesium-based metal coating is 200µm, the degradation time of the magnesium-based metal coating is about 30 days, and the complete degradation time of the polymer material layer is ≥10 week.

Embodiment 3

[0030] The polyacrylic acid sheet is placed in the furnace body of the deposition chamber, with a thickness of 0.8 mm, a length of 3 cm, and a width of 1 cm. The magnesium raw material is placed in the evaporation chamber. The content of Cu is 0.5%, the content of Zn is 3%, the content of Sr is 2%, the balance is Mg, and the limit vacuum (10 -4 Pa). Set the sublimation temperature of the magnesium-based metal to 450°C and the working pressure to 1×10 -2 Pa, the deposition temperature is 100°C, the deposition time is 60min, the sample is taken out after cooling with the furnace, the thickness of the magnesium-based metal coating is 200µm, the degradation time of the magnesium-based metal coating is about 20 days, and the polymer material layer is completely degraded in ≥8 week. Magnesium is degraded to be alkaline and polyacrylic acid is degraded to be acidic, so the degradation of both materials will be accelerated.

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Abstract

The invention belongs to the technical field of dentistry implant filling materials and implant material antibiosis, and particularly relates to a magnesium-based metal polymer composite bone-guided regeneration membrane and a preparation method thereof. A metal magnesium-based metal coating is prepared on a polymer material by adopting a vacuum evaporation technology, the thickness of a polymer matrix is 100-1000m, and the thickness of the coating is 0.1-1000m. The problems of bone bioactivity and infection of an existing implant material can be solved, and the permanent implant material obtained through the method meets the mechanical property requirements of various implant positions, has excellent biocompatibility and meanwhile has a sterilization function.

Description

technical field [0001] The invention belongs to the field of medical materials, in particular to the field of dental implant filling materials and implant material antibacterial technology; in particular, it relates to a magnesium-based metal-polymer composite bone conduction regeneration membrane and a preparation method thereof. Background technique [0002] Due to bone defects and tooth loss caused by trauma and bone tumors, a large number of denture implants are required. However, dental implants still require abundant gum bone. Denture implants are then performed. The bone tissue and connective tissue in the mouth grow together, and the connective tissue grows faster, preferentially occupying the space that the bone tissue should occupy, resulting in insufficient bone mass. This requires wrapping the bone implant material with an osteoconductive membrane, so that the human bone has enough space to fuse with the bone implant material, and the hoof tissue is isolated on ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/02A61L31/10A61L31/14A61L31/16C23C14/20C23C14/24C22C23/04
CPCA61L31/022A61L31/10A61L31/16A61L31/148C23C14/20C23C14/24C22C23/04A61L2300/404A61L2300/412A61L2430/12
Inventor 于晓明由雪儿姜浩宇
Owner SHENYANG LIGONG UNIV
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