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Chitosan microcapsule modified acrylic bone cement and preparation method thereof

A technology of chitosan microcapsules and acrylic acid, which is applied in the field of medical biomaterials and can solve problems such as the decline in mechanical properties

Active Publication Date: 2021-09-14
XIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method increases the vacuoles in the cured product by loading dextran to promote drug release, resulting in a serious decline in mechanical properties.

Method used

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  • Chitosan microcapsule modified acrylic bone cement and preparation method thereof
  • Chitosan microcapsule modified acrylic bone cement and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] A kind of preparation method of chitosan microcapsule modified acrylic acid bone cement of the present invention comprises the following steps:

[0061] Step 1, preparing chitosan microcapsules loaded with methotrexate;

[0062] Step 1.1, 2g chitosan is dissolved in the acetic acid solution of 100ml1wt%, obtains the chitosan solution that concentration is 2wt% after mechanical stirring, ultrasonic defoaming as shell layer, 1.5g methotrexate is dissolved in 100ml to remove In deionized water, after stirring evenly, a methotrexate solution with a concentration of 1.5wt% is obtained as a nuclear layer spinning solution precursor;

[0063] Step 1.2, the acetic acid solution of chitosan is placed in syringe 1, and the aqueous drug solution is placed in syringe 2, and at a push speed ratio of 2 to 1 and a voltage of 15KV, push to T=30°C, 5wt% NaOH and 1wt% %Na 2 SO 4 coagulated in ethanol solution, and freeze-dried to obtain chitosan microcapsules loaded with bone tumor dr...

Embodiment 2

[0071] A kind of preparation method of chitosan microcapsule modified acrylic acid bone cement of the present invention comprises the following steps:

[0072] Step 1, preparation of loaded bortezomib chitosan microcapsules

[0073] Step 1.1, 4g chitosan is dissolved in 100ml 1wt% acetic acid solution, after mechanical stirring, ultrasonic degassing, obtain the chitosan solution that concentration is 4wt% as shell layer, 2g bortezomib is dissolved in 100ml deionized water After stirring evenly, a bortezomib solution with a concentration of 2wt% was obtained as the precursor of the nuclear layer spinning solution;

[0074] Step 1.2, the acetic acid solution of chitosan is placed in syringe 1, and the aqueous drug solution is placed in syringe 2, and the pushing speed ratio is 3 to 1, and the voltage is 17KV, pushing to T=30°C, 5wt% NaOH and 1wt% %Na 2 SO 4 The chitosan microcapsules loaded with bone tumor drugs were obtained after freeze-drying in ethanol solution.

[0075]...

Embodiment 3

[0082] A kind of preparation method of chitosan microcapsule modified acrylic acid bone cement of the present invention comprises the following steps:

[0083]Step 1, prepare chitosan microcapsules loaded with doxorubicin

[0084] Step 1.1, dissolve 3g of chitosan in 100ml of 1wt% acetic acid solution, obtain a concentration of 3wt% chitosan solution as the shell layer after mechanical stirring and ultrasonic degassing, and dissolve 2g of doxorubicin in 100ml of deionized water After stirring evenly, a doxorubicin solution with a concentration of 2wt% was obtained as the precursor of the nuclear layer spinning solution;

[0085] Step 1.2, the acetic acid solution of chitosan is placed in syringe 1, and the aqueous drug solution is placed in syringe 2, and at a push speed ratio of 3 to 1 and a voltage of 23KV, push to T=30°C, 5wt% NaOH and 1wt% %Na 2 SO 4 The chitosan microcapsules loaded with bone tumor drugs were obtained after freeze-drying in ethanol solution.

[0086] ...

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Abstract

The invention discloses chitosan microcapsule modified acrylic bone cement. The chitosan microcapsule modified acrylic bone cement is formed by mixing a solid phase and a liquid phase, wherein the solid phase comprises a bone tumor drug loaded chitosan microcapsule, an antibiotic loaded water-swellable P (MMA-AA) copolymer nano-microsphere and polymethyl methacrylate; the liquid phase comprises methyl methacrylate, an accelerant and a polymerization inhibitor. The invention further discloses a preparation method of the chitosan microcapsule modified acrylic bone cement. The preparation method comprises the following steps of: uniformly mixing the bone tumor drug loaded chitosan microcapsule, the antibiotic loaded water-swellable P (MMA-AA) copolymer nano-microsphere and polymethyl methacrylate to obtain the solid phase; uniformly mixing methyl methacrylate, the accelerant and the polymerization inhibitor to obtain the liquid phase; and uniformly mixing the solid phase and the liquid phase. The chitosan microcapsule modified acrylic bone cement has a remarkable value for treating postoperative bone tumors, and has relatively high drug loading capacity, drug release rate and drug accumulated release amount under the condition that the compressive strength is basically unchanged.

Description

technical field [0001] The invention belongs to the technical field of medical biomaterials, in particular to a chitosan microcapsule modified acrylic bone cement and a preparation method of the chitosan microcapsule modified acrylic bone cement. Background technique [0002] With the aging of the population and the changes in lifestyle and diet structure, the number of osteoporosis patients has increased, which has led to an increase in the incidence of OVCE and osteoarthritis. It is usually treated with vertebroplasty and joint replacement, but there are infection problems after surgery and the need for bone repair. [0003] Clinically, autologous bone, allogeneic bone, and bone cement filling are currently used for treatment. Among them, PMMA bone cement filling is a multifunctional, economical, safe and efficient bone grafting method, which is widely used clinically. However, people who need to be treated with bone cement often have other orthopedic diseases, such as o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/20A61L27/16A61L27/50A61L27/54
CPCA61L27/20A61L27/16A61L27/50A61L27/54A61L2430/02A61L2300/602A61L2300/406A61L2300/41A61L2300/416A61L2400/12A61L2300/622C08L5/08C08L33/12C08L33/02C08L39/06C08L29/04
Inventor 汤玉斐孙雅妮陈磊赵康吴子祥张博张诗彤
Owner XIAN UNIV OF TECH
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