Polysaccharide composition with skin barrier repairing function and application thereof

A skin barrier repair and composition technology, which is applied in the fields of dermatology and cosmetics, can solve problems such as inability to damage the skin barrier function, achieve the effect of reducing the transepidermal water loss rate and improving the moisturizing effect

Pending Publication Date: 2021-09-17
INFINITUS (CHINA) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is to overcome the defects and deficiencies that the existing polysaccharide composition cannot ...

Method used

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  • Polysaccharide composition with skin barrier repairing function and application thereof
  • Polysaccharide composition with skin barrier repairing function and application thereof
  • Polysaccharide composition with skin barrier repairing function and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0040] A polysaccharide composition with skin barrier repairing function, the polysaccharide composition includes Tremella polysaccharide, Dendrobium candidum polysaccharide, Saussurea sauraceae polysaccharide and β-glucan, wherein in the polysaccharide composition, Tremella polysaccharide, Dendrobium candidum polysaccharide, Saussurea sauraceae polysaccharide and β-glucan - The mass ratio of dextran is 0.1:0.5:0.1:0.1.

[0041] Wherein the preparation method of tremella polysaccharide is as follows:

[0042] (1) Take the dried white fungus, remove worms or spoiled parts, pulverize with a powder machine, and pass through a 60-mesh sieve;

[0043](2) Take medicinal material powder and add 1:10 to 1:40 solid-liquid ratio, add deionized water, at a temperature of 50°C, use ultrasonic leaching for 30 minutes, and heat for 2 hours;

[0044] (3) Centrifuge the tremella extract obtained in (2) at 4000r / min for 15min, and filter the supernatant;

[0045] (4) Freeze-drying the white ...

Embodiment 2

[0057] A polysaccharide composition with skin barrier repairing function, the polysaccharide composition includes Tremella polysaccharide, Dendrobium candidum polysaccharide, Saussurea sauraceae polysaccharide and β-glucan, wherein in the polysaccharide composition, Tremella polysaccharide, Dendrobium candidum polysaccharide, Saussurea sauraceae polysaccharide and β-glucan - The mass ratio of dextran is 10:20:20:5.

[0058] Wherein, the preparation method of Tremella polysaccharide, Dendrobium officinale polysaccharide and Tianshan Snow Lotus polysaccharide is the same as that of Example 1.

Embodiment 3

[0060] A polysaccharide composition with skin barrier repairing function, the polysaccharide composition includes Tremella polysaccharide, Dendrobium candidum polysaccharide, Saussurea sauraceae polysaccharide and β-glucan, wherein in the polysaccharide composition, Tremella polysaccharide, Dendrobium candidum polysaccharide, Saussurea sauraceae polysaccharide and β-glucan - The mass ratio of dextran is 0.5:1:0.5:0.2.

[0061] Wherein, the preparation method of Tremella polysaccharide, Dendrobium officinale polysaccharide and Tianshan Snow Lotus polysaccharide is the same as that of Example 1.

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Abstract

The invention discloses a polysaccharide composition with a skin barrier repairing function and application thereof. The polysaccharide composition comprises tremella polysaccharide, dendrobium officinale polysaccharide, saussurea involucrate polysaccharide and beta-glucan. The polysaccharide composition provided by the invention is mainly used for effectively improving the moisturizing effect of skin through the effect of repairing a skin barrier and reducing the percutaneous water loss rate of the skin, and the average value of the percutaneous water loss rate can be reduced to 15.3% +/- 2.2. Meanwhile, the combined polysaccharide component can also be used as an information molecule to widely participate in physiological processes such as mutual recognition of intercellular ligands and receptors and intercellular signal transduction, the mRNA average relative amplification factor of a silk-like protein (FLG) expression factor and the mRNA average relative amplification factor of a paphiopediin (LOR) expression factor are increased, and the content of FLG and LOR can be well increased, so that the polysaccharide composition has a good skin barrier repairing function.

Description

technical field [0001] The present invention relates to the technical field of dermatology and cosmetics, and more specifically relates to a polysaccharide composition with the function of repairing skin barrier and its application. Background technique [0002] With the destruction of the global ozone layer, the amount of ultraviolet radiation continues to increase, and preventing ultraviolet rays from damaging the skin has become a global trend. Ultraviolet damage to the skin refers to the skin damage process that is different from natural damage caused by exogenous factors, mainly ultraviolet rays (including UVA, UVB). UVA wavelength is relatively long, at 320-400nm, with strong penetrating ability, can penetrate the surface layer of the skin, penetrate deep into the tissue below the dermis, and can destroy collagen, elastic fiber tissue and other fine structures inside the skin, UVB, with a wavelength of 290-320nm, can Make the skin sunburned and sunburned in a short ti...

Claims

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Application Information

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IPC IPC(8): A61K8/73A61Q19/00
CPCA61K8/73A61Q19/004A61Q19/00A61K2800/5922
Inventor 杨凯业张泽钧刘光荣李莉楠杜志云韩萍
Owner INFINITUS (CHINA) CO LTD
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