Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Subcutaneous implant rod for long-acting blood sugar reduction, and preparation method of subcutaneous implant rod

A blood sugar-lowering, long-acting technology, applied in non-active ingredient medical preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve problems such as inability to achieve long-term stable blood sugar and insignificant therapeutic effect of catgut embedding, etc. Achieve the effect of improving mechanical properties and thermal properties, easy to handle, and non-toxic

Pending Publication Date: 2021-09-28
吕汇川
View PDF0 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] There is also a precedent of using traditional Chinese medicine catgut embedding therapy to treat diabetes, but the therapeutic effect of catgut embedding is not significant, and the effect of long-term stable blood sugar cannot be achieved

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Subcutaneous implant rod for long-acting blood sugar reduction, and preparation method of subcutaneous implant rod
  • Subcutaneous implant rod for long-acting blood sugar reduction, and preparation method of subcutaneous implant rod

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0040] The present invention uses micelles of diblock copolymers to prepare drug carriers for implant rods, specifically, the preparation method for long-acting hypoglycemic subcutaneous implant rods includes the following steps:

[0041] Step 1: Preparation of polycaprolactone diblock copolymer micelles: ring-opening polymerization of polycaprolactone initiated by polyethylene glycol. The ring-opening polymerization of polycaprolactone, and considering the safety and compatibility of PCL-PEG copolymer as a biomedical material when it acts on the human body, our laboratory directly uses polyethylene glycol PEG as a macromolecular initiator, poly Caprolactone PCL is a monomer, because it is used in human body, avoiding the use of toxic metal catalysts, successfully prepared PCL-PEG-diblock copolymer. Preparation of PCL-PEG-diblock copolymer micelles: Add polycaprolactone and polyethylene glycol to the reaction kettle, close the reaction kettle, vacuumize, heat and stir for 4-6 ...

Embodiment 1

[0044] The formula of this embodiment can produce the diameter of implant rod is 3mm, and length is 50mm, and the weight of each implant rod is 300mg, and each implant rod contains raw material medicine is 100mg.

[0045] Specifically, a subcutaneous implant stick for long-acting hypoglycemia, the formula of which is: polycaprolactone 10g, polyethylene glycol 5g, polyvinylpyrrolidone 2g, glibenclamide 5g, rosiglitazone 5g, The total weight is 27g, and each stick is 300mg, making about 90 sticks.

[0046] The preparation process of above-mentioned implant rod is:

[0047] Step 1: Preparation of polycaprolactone diblock copolymer micelles: ring-opening polymerization of polycaprolactone initiated by polyethylene glycol. The ring-opening polymerization of polycaprolactone, and considering the safety and compatibility of PCL-PEG copolymer as a biomedical material when it acts on the human body, our laboratory directly uses polyethylene glycol PEG as a macromolecular initiator, po...

Embodiment 2

[0050] The formula of this embodiment can produce implanted rods with a diameter of 3 mm and a length of 25 mm, each implanted rod has a weight of 15 mg, and each implanted rod contains 50 mg of raw material.

[0051] Among them, the specific formula of this embodiment is: polycaprolactone 15g, polyethylene glycol 7g, polyvinylpyrrolidone 1g, glibenclamide 15g, rosiglitazone 2g, total weight 40g, each 300mg, made about 133 sticks.

[0052] The preparation method of this embodiment is the same as that of Example 1.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
lengthaaaaaaaaaa
diameteraaaaaaaaaa
Login to View More

Abstract

The invention discloses a subcutaneous implant rod for long-acting blood sugar reduction, and a preparation method of the subcutaneous implant rod. A diblock copolymer is adopted as a carrier, and the formula comprises the following substances in parts by weight: 10-20 parts of polycaprolactone, 5-10 parts of polyethylene glycol, 1-5 parts of polyvinylpyrrolidone and 5-20 parts of bulk drugs, wherein the bulk drug is prepared by combining two drugs, namely glibenclamide and rosiglitazone, and the mass ratio of the glibenclamide to the rosiglitazone in the bulk drug is (1-20): 1. After the subcutaneous implant rod disclosed by the invention is implanted subcutaneously, direct long-term sustained-release administration is carried out for realizing long-term treatment and stabilization of blood sugar, the diblock copolymer is adopted as the carrier, the problem that an existing implant rod carrier is short in acting time is solved, the preparation method of the subcutaneous implant rod disclosed by the invention is simple, materials can be easily obtained, and the production process is simple and can be easily mastered. The subcutaneous implant rod prepared by the invention is implanted under the skin of the human body, and a comfort level is good after the subcutaneous implant rod prepared by the invention is implanted under the skin of the human body since a biological material has complete degradability, good biocompatibility and no toxicity.

Description

technical field [0001] The invention relates to a subcutaneous slow-release drug implant rod and a preparation method thereof. The implant rod is implanted under the skin, and is used for treating and stabilizing corresponding diseases according to the pharmacological properties of drugs mixed into the implant rod, specifically a A long-acting hypoglycemic subcutaneous implant stick, which is used for long-term stabilization of normal blood sugar. Background technique [0002] At present, the treatment of type 2 diabetes at home and abroad mostly relies on oral hypoglycemic drugs to maintain normal and balanced blood sugar. The drug has a short duration of action and needs to be taken orally three or two times a day. Oral administration of a large amount of hypoglycemic drugs has serious side effects, causing systemic and gastrointestinal reactions, as well as great damage to liver and kidney functions. [0003] There is also a precedent of using catgut embedding therapy i...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K47/34A61K47/10A61K47/32A61K31/64A61K31/4439A61P3/10C08G63/664
CPCA61K9/0024A61K47/34A61K47/10A61K47/32A61K31/64A61K31/4439A61P3/10C08G63/664A61K2300/00
Inventor 吕鹏威
Owner 吕汇川
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com