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Antibacterial oxygen solution and preparation method and application thereof

An antibacterial oxygen and solution technology, used in antibacterial, antifungal, topical antibacterial agents, etc., can solve the problems of low dissolved oxygen concentration, small wound oxygen supply, complicated operation, etc., and achieve the effect of high dissolved oxygen concentration

Pending Publication Date: 2021-10-12
广州丰歌生物科技有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Related technologies disclose the use of air compressors and micro-nano bubble generators, the use of enzymatic reactions to release oxygen, oxygen filling, and other methods to prepare hyperoxic solutions. These methods require specific equipment, or oxygen is still released in the form of gaseous oxygen, and the concentration of dissolved oxygen is low. and other problems, the operation is complicated, the oxygen supply effect on the wound is small, and it does not have antibacterial properties

Method used

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  • Antibacterial oxygen solution and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Dissolve 0.1 g of carboamide peroxide in 33.78 g of water, and the resulting aqueous solution is A component. Dissolve 0.02g sodium hypochlorite in 60g water, add 1g perfluoroalkyl polyoxyethylene ether DuPont And 5g fluorooctyl bromide, the solution formed is B component. Slowly add the solution of component A to component B. After the reaction is completed (no bubbles will be generated in the solution), inject 0.1 g of diethylenetriaminepentamethylenephosphonic acid, and leave it in a closed container to obtain an oxygen-enriched antibacterial solution.

Embodiment 2

[0033] Dissolve 1.5g of carboxamide peroxide in 20g of water, and the resulting aqueous solution is A component. Dissolve 0.5g of potassium hypochlorite in 37g of water, add 15g of perfluoroalkyl alcohol polyoxyethylene ether and 25g of perfluorooctane, and the formed solution is component B. Slowly add the solution of component A to component B, inject 1g of ethylenediaminetetramethylenephosphonic acid after the reaction is completed, and let it stand in a closed container to obtain an oxygen-enriched antibacterial solution.

Embodiment 3

[0035] Dissolve 0.5g of carboxamide peroxide in 24.25g of water, and the resulting aqueous solution is A component. Dissolve 0.05g of sodium hypobromite in 60g of water, add 5g of perfluoropolyether sulfonate DuPont And 10g perfluorotripropylamine, the solution formed is B component. Slowly add the solution of component A to component B, inject 0.2g of aminotrimethylene phosphonic acid after the reaction is completed, and let it stand in a closed container to obtain an oxygen-enriched antibacterial solution.

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Abstract

The invention discloses an antibacterial oxygen solution and a preparation method and application thereof. The antibacterial oxygen solution is prepared from the following raw materials: peroxide, hypohalite, a solubilizer, a fluorocarbon, a hydrogen peroxide stabilizer and water. According to the antibacterial oxygen solution, an external oxygenation step is not needed, oxygen can be generated through reaction in a system, the very high dissolved oxygen concentration can be achieved, meanwhile, hydrogen peroxide released in the system enables the solution to have the antibacterial property, and bacteria such as staphylococcus aureus, escherichia coli and candida albicans can be killed.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to an antibacterial oxygen solution and its preparation method and application. Background technique [0002] An important reason why chronic wounds such as diabetic feet are difficult to heal is the lack of blood supply to the wound site, which prevents oxygen from being delivered to the wound through the blood. The current use of oxygen therapy in chronic wound healing has shown very significant efficacy. At present, there are two methods of oxygen therapy. One is hyperbaric oxygen therapy, which has become one of the important methods for treating chronic difficult-to-heal wounds. However, hyperbaric oxygen therapy requires special equipment and is inconvenient to use in daily life. The other is local oxygen therapy, which is to provide oxygen in the local area of ​​the wound. The specific implementation methods of local oxygen therapy include continuous blowing of pur...

Claims

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Application Information

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IPC IPC(8): A61K33/40A61K9/08A61K47/10A61K47/18A61K47/20A61P17/02A61P31/02A61P31/04A61P31/10A61K33/20
CPCA61K33/40A61K33/20A61K9/08A61K47/10A61K47/20A61K47/18A61P17/02A61P31/04A61P31/10A61P31/02Y02A50/30
Inventor 刘志阳刘群峰吕惠平
Owner 广州丰歌生物科技有限责任公司
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