The invention relates to the technical field of
organic synthesis, in particular to a preparation method of 1, 4-butanediamine, which comprises the following steps: S1, heating and melting
adipic acid, and carrying out ammonification reaction on the
adipic acid in the
molten state and
ammonia gas; s2, after the ammoniation reaction is finished, raising the temperature to carry out
dehydration reaction, enabling by-product water and unreacted
ammonia gas to enter a
recovery device through a condensation
system, and carrying out
dehydration reaction to obtain
adipamide; and S3, after the
dehydration reaction is finished, adding a
hypohalite aqueous solution and alkali, heating for reaction, and after the reaction is finished, performing post-treatment purification to obtain a 1, 4-butanediamine product. The preparation method of the 1, 4-butanediamine is good in selectivity, the purity of the prepared 1, 4-butanediamine is 99.5% or above, and the yield of the prepared 1, 4-butanediamine is 90% or above. The preparation method disclosed by the invention is simple to operate, low in
raw material price, mild in reaction condition, small in danger coefficient and convenient for industrial production.