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Multi-vitamin iron capsule and preparation method thereof

A technology of vitamins and refining methods, which is applied in capsule delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve problems affecting application, uneven crystal surface energy, and high content of amorphous lactose, so as to improve stability and Dissolution, absorption promotion, high dissolution effect

Pending Publication Date: 2021-10-22
海南金贝康制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the microcrystallization of lactose in the industry mainly adopts mechanical grinding and spray drying. The mechanical grinding method prepares microcrystalline lactose crystals with great differences in crystal morphology, uneven crystal surface energy, and wide particle size distribution; spray drying can obtain lactose with uniform particle size. crystals, but the high content of amorphous lactose in the product seriously affects its subsequent application

Method used

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  • Multi-vitamin iron capsule and preparation method thereof
  • Multi-vitamin iron capsule and preparation method thereof
  • Multi-vitamin iron capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1 A kind of preparation method of folic acid

[0033] The present embodiment is a preparation method of folic acid, and the specific preparation process includes the following steps carried out in sequence:

[0034] 1) Under nitrogen protection, take 3.6g (20mmol) of 1,1,3,3-tetramethoxy-2-propanol and add it to 40mL aqueous hydrochloric acid solution with a concentration of 1moL / L, stir at room temperature for 5min, then add 10.65g (40mmol) N-p-aminobenzoyl-L-glutamic acid, then stirred and reacted at 50°C for 1h, added 200mL of water after the reaction was completed, placed at room temperature for 24h to crystallize, filtered, washed with water, and dried in vacuo to obtain 10.0g of diimide Solid, yield 85.54%.

[0035] Under nitrogen protection, add 10 g of diimine solid and 4.15 g of sodium sulfide to 35 mL of water, add 2 mol / L of sodium carbonate aqueous solution while stirring until the pH of the system is 6, then add 3.92 g of triaminopyrimidine sulf...

Embodiment 2～5

[0040] The preparation method of embodiment 2~5 folic acid

[0041] Embodiments 2 to 5 are respectively a preparation method of folic acid, and their steps are basically the same as those in Embodiment 1, the only difference being that the process parameters are different, see Table 1 for details:

[0042] List of each technological parameter in the embodiment 2~5 of table 1

[0043]

[0044]

[0045] The contents of the other parts of Embodiments 2 to 5 are the same as those of Embodiment 1.

Embodiment 6

[0046] Embodiment 6 A kind of refining method of lactose

[0047] Add 1kg of lactose raw material to 2.5L of water, stir and heat to 56°C to fully dissolve, maintain the obtained lactose solution at 50°C, add 10g of activated carbon and stir for decolorization for 30min, filter while it is hot, then filter with an ultrafiltration membrane, then add 5L of ethanol, and slowly cool down Crystallize at 30°C for 4 hours, collect the crystals by centrifugation, and dry in vacuum at 50°C for 8 hours to obtain 0.827kg of lactose, which is marked as RT6.

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Abstract

The invention provides a multivitamin iron capsule and a preparation method thereof, and belongs to the technical field of medicine preparation, the preparation method comprises the following steps: S1, taking 49.19 parts by weight of ferrous fumarate and 146.28 parts by weight of lactose, and uniformly mixing to obtain a mixture X; S2, uniformly mixing a part of the mixture X with 0.5 part by weight of folic acid and 0.23 part by weight of vitamin B12 powder to obtain a mixture Y; S3, uniformly mixing the residual mixture X with 200.6 parts by weight of vitamin C, 3.2 parts by weight of magnesium stearate and the mixture Y to obtain a material to be encapsulated; and S4, taking the material to be encapsulated, and encapsulating to obtain the multivitamin iron capsule. Therefore, the multi-vitamin iron capsule with good stability and high dissolution rate is obtained, and is more beneficial to absorption and utilization by a human body.

Description

technical field [0001] The invention relates to the preparation of capsules, in particular to a multivitamin iron capsule and a preparation method thereof. Background technique [0002] Vitamins are a class of trace organic substances that maintain normal physiological functions of humans and animals. Generally, these substances can be obtained from the daily diet. Specifically, they play an important role in the growth, metabolism, and development of the human body. Iron is an essential component of human cells. It has hematopoietic function, participates in the production of hemoglobin and the synthesis of cytochromes and various enzymes, and promotes growth. Iron also plays a role in transporting and carrying nutrients in the blood. If iron deficiency will lead to iron deficiency anemia, it will also cause immune function decline and metabolic disorders in severe cases. Therefore, vitamins and iron are all necessary nutrients for the human body, and multivitamin iron cap...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/295A61K31/35A61K31/519A61K31/375A61K31/714C07D487/04A61P3/02A61K9/48A61K47/26
CPCA61K31/295A61K31/35A61K31/519A61K31/375A61K31/714A61K9/4858C07D487/04A61P3/02
Inventor 邓文峰刘海琼符晓霞
Owner 海南金贝康制药有限公司