Preparation method and application of dopamine/calcium phosphate hybrid micron flower

A technology of dopamine acetic acid and dopamine, applied in medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc., can solve the problems of low drug release, poor biocompatibility, and poor thermal stability. Achieve the effect of high specific surface area, less impurities and good load capacity

Active Publication Date: 2021-10-22
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Aiming at the deficiencies of the prior art, in order to solve the shortcomings of existing drug-loaded materials such as poor mechanical and thermal stability, low drug loading rate, poor biocompatibility, and low drug release, the present invention provides a dopamine / calcium phosphate hybrid micron flower Materials and their preparation methods and applications

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  • Preparation method and application of dopamine/calcium phosphate hybrid micron flower
  • Preparation method and application of dopamine/calcium phosphate hybrid micron flower
  • Preparation method and application of dopamine/calcium phosphate hybrid micron flower

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Embodiment 1

[0059] In this embodiment, a method for preparing a dopamine / calcium phosphate hybrid micron flower material is carried out according to the following steps:

[0060] (1) Deionized water prepares 1wt% acetic acid aqueous solution, prepares the dopamine acetic acid aqueous solution of concentration 2mg / mL;

[0061] (2) Deionized water preparation concentration is the sodium tripolyphosphate aqueous solution of 100mg / mL, dropwise is added dropwise in the dopamine aqueous solution under stirring, obtains dopamine / sodium tripolyphosphate complex mixture, the mass of dopamine and sodium tripolyphosphate The ratio is 1:20;

[0062] (3) Transfer the dopamine / sodium tripolyphosphate complex mixture to a water bath, use deionized water to prepare 110mM calcium chloride aqueous solution, add it dropwise to the above complex mixture, heat and stir, after the reaction , centrifuged for 5 minutes, removed the supernatant to collect the precipitate, resuspended with deionized water, and wa...

Embodiment 2

[0065] A preparation method of a dopamine / calcium phosphate hybrid micron flower material, carried out according to the following steps:

[0066] (1) Deionized water prepares 1.5wt% acetic acid aqueous solution, prepares the dopamine acetic acid aqueous solution of concentration 5mg / mL;

[0067] (2) Prepare a sodium tripolyphosphate aqueous solution with a concentration of 50 mg / mL in deionized water, and add it dropwise to the dopamine aqueous solution under stirring to obtain a dopamine / sodium tripolyphosphate complex mixture, the mass of dopamine and sodium tripolyphosphate The ratio is 2:23;

[0068] (3) Transfer the dopamine / sodium tripolyphosphate complex mixture to a water bath, use deionized water to prepare 100mM calcium chloride aqueous solution, add it dropwise to the above complex mixture, heat and stir, and then centrifuge for 5min , remove the supernatant to collect the precipitate, resuspend with deionized water, and wash the precipitate 3 times; wherein, the s...

Embodiment 3

[0071] A method for preparing a dopamine / calcium phosphate hybrid micron flower material is carried out according to the following steps:

[0072] (1) Deionized water prepares 0.75wt% acetic acid aqueous solution, prepares dopamine acetic acid aqueous solution with concentration 4mg / mL;

[0073] (2) Prepare a phosphate buffered saline solution with a concentration of 100mg / mL in deionized water, and add it dropwise to the dopamine aqueous solution under stirring to obtain a dopamine / phosphate buffered saline complex mixture, the mass of dopamine and phosphate buffered saline The ratio is 1:10;

[0074] (3) Transfer the dopamine / phosphate buffered saline complex mixture to a water bath, use deionized water to prepare a 150mM calcium chloride aqueous solution, add it dropwise to the above complex mixture, heat and stir, and then centrifuge for 5min , remove the supernatant to collect the precipitate, resuspend with deionized water, and wash the precipitate 3 times; wherein, the...

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Abstract

The invention provides a preparation method and application of a dopamine / calcium phosphate hybrid micron flower. The diameter of the dopamine / calcium phosphate hybrid micron-flower material is 3-10 microns, the dopamine / calcium phosphate hybrid micron-flower material is composed of regular porous nanosheets with the thickness of about 20 nanometers and the width of about 300-800 nanometers, and the dopamine / calcium phosphate hybrid micron-flower material has a complete three-dimensional structure, an extremely high specific surface region and high porosity. The material can be used as a drug carrying material or a drug carrier for preparing a drug delivery system. The drug delivery system has high drug loading rate, and can controllably release drugs under different pH conditions.

Description

technical field [0001] The invention relates to a preparation method and application of dopamine / calcium phosphate hybrid micro-flowers, belonging to the technical field of organic / inorganic hybrid materials. Background technique [0002] Organic-inorganic hybrid materials combine the excellent properties of organic components and inorganic components, and at the same time exhibit some new properties, so they have attracted much attention and been widely studied. Calcium phosphate, as the main inorganic component of biological hard tissues (bone, tooth, tendon, etc.), is one of the most widely studied organic-inorganic composite biomaterials. The inherent biocompatibility, bioactivity, mechanical and thermal stability, and easy surface modification of calcium phosphate make it an excellent material for wide application in biomedical fields, such as drug delivery, cancer therapy, tissue engineering, etc. In order to further meet the needs of biomedical applications and expan...

Claims

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Application Information

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IPC IPC(8): A61K47/69A61K9/14A61K47/02A61K47/18A61K31/704A61P35/00
CPCA61K9/143A61K9/145A61K47/6949A61K31/704A61P35/00
Inventor 李峻柏孙楠贾怡
Owner INST OF CHEM CHINESE ACAD OF SCI
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