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Polydopamine-zwitterionic polymer anti-adhesion coating modification method and application thereof

A technology of zwitterion and polydopamine, which is applied in the field of polymer materials and medical implants, can solve the problems that it is difficult to achieve the effect of resisting long-term and chronic foreign body reactions, and achieve the avoidance of initiator residues, good biocompatibility, and biological good compatibility

Inactive Publication Date: 2021-10-22
ZHUJIANG HOSPITAL SOUTHERN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although the electrode modified with dexamethasone can resist the acute foreign body reaction after electrode implantation, it is difficult to achieve the effect of anti-long-term chronic foreign body reaction after the drug is released.

Method used

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  • Polydopamine-zwitterionic polymer anti-adhesion coating modification method and application thereof
  • Polydopamine-zwitterionic polymer anti-adhesion coating modification method and application thereof
  • Polydopamine-zwitterionic polymer anti-adhesion coating modification method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0032] Example 1. This embodiment uses the electrode as a medical implant to illustrate the method for modifying the electrode with polydopamine-zwitterionic polymer anti-adhesion coating:

[0033] 1. In an ice bath, dissolve 1.89 g of dopamine hydrochloride (DA·HCl), 4.52 g of tert-butyldimethylsilyl chloride (TBDMS) and 3.4 g of imidazole in 30 ml of dichloromethane (DCM) solution. After the reaction ceased exothermic, the ice bath was removed. Next, the reaction was continued for 2 hours at 25° C. under nitrogen. The precipitate in the reacted mixed solution was removed by centrifugation, the supernatant was extracted and extracted to separate the organic phase, and then concentrated by rotary evaporation. The concentrated solution was purified by silica gel chromatography (dichloromethane:methanol=4:1), and then the purified solution was concentrated and vacuum-dried for 8 hours to obtain an intermediate product in the form of a yellow oily liquid. The reaction process ...

Embodiment 2

[0042] Example 2. This embodiment uses polyetheretherketone (PEEK) as a medical implant to illustrate the method for modifying the surface of PEEK with polydopamine-zwitterionic polymer anti-adhesion coating:

[0043] 1. 2.27g of dopamine hydrochloride (DA·HCl), 5.42g of tert-butyldimethylsilyl chloride (TBDMS) and 4.08g of imidazole were dissolved in 30ml of chloroform solution and reacted at 0°C. Next, the reaction was continued for 2 hours at 25° C. under nitrogen. The precipitate in the reacted mixed solution was removed by centrifugation, the supernatant was extracted and extracted to separate the organic phase, and then concentrated by rotary evaporation. The concentrated solution was purified by silica gel chromatography (dichloromethane:methanol=8:1), and then the purified solution was concentrated and vacuum-dried for 10 hours to obtain an intermediate product. The reaction process is as follows:

[0044]

[0045] 2. Dissolve 2.85g of the intermediate product an...

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Abstract

The invention discloses a polydopamine-zwitterionic polymer anti-adhesion coating modification method. The method comprises the following steps: soaking a modified object in a mixed solution of trihydroxymethyl aminomethane, dopamine hydrochloride, a zwitterionic polymer and a strong electrolyte solution to form the anti-adhesion coating, and reducing foreign matter reaction in an anti-cell adhesion manner. Therefore, a long-term stable anti-fibrosis effect can be obtained without introducing drugs. According to the method, the polymer is firstly formed, and then the polymer is grafted to the surface of an electrode instead of directly initiating polymerization on the surface of the electrode, so that toxic small molecules are removed through sufficient dialysis before grafting, and good biocompatibility is ensured. By utilizing the anti-polyelectrolyte effect of zwitterions, the electrolyte is added into the coating solution, so that the solubility of the zwitterionic polymer can be increased, and the high grafting density is ensured.

Description

technical field [0001] The invention relates to the fields of polymer materials and medical implants, in particular to the preparation of zwitterionic polymers and their application to medical implants. Background technique [0002] In recent years, implanted medical devices have been widely used clinically, such as vascular intervention, orthopedic implants and artificial organs. However, medical devices will cause different degrees of foreign body reactions in the body, and as the implantation time prolongs, fibrous cysts will form around the implant, which seriously affects the long-term effect. [0003] Taking cochlear implants as an example, implanted electrodes are usually considered "foreign objects" by the host's immune system, causing severe foreign body reactions in the cochlea, and thick fibrous capsules will form around the electrodes, which will not only affect the conduction of electrical stimulation, but also Increased power consumption seriously affects the ...

Claims

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Application Information

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IPC IPC(8): C08F120/38C08F8/00A61L27/34
CPCC08F120/38C08F8/00A61L27/34C08F2438/01C08L33/14
Inventor 张宏征陈安宁陈东秀许木清
Owner ZHUJIANG HOSPITAL SOUTHERN MEDICAL UNIV
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