Molecularly imprinted electrochemical sensor based on FeS2/C/MQDs/GCE modified electrode and preparation method thereof

A technology for modifying electrodes and molecular imprinting, applied in scientific instruments, material analysis through electromagnetic means, instruments, etc., can solve the problems of complex and expensive detection methods, and achieve the effect of wide practical application prospects and good reproducibility

Active Publication Date: 2021-10-26
SICHUAN AGRI UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] Aiming at the above problems existing in the prior art, the present invention provides a FeS-based 2 / C / MQDs / GCE Modified Electrode Molecularly Imprinted Electrochemical Sensor and Its Preparation Method Based on Ti 3 C 2 Mxene Quantum Dots (MQD) and FeS 2 / C nanomaterial modified glassy carbon electrode (FeS 2 / C / MQDs / GCE), and it was used to prepare a molecularly imprinted dual-template electrochemical sensor for the simultaneous detection of dipyridamole (DIP) and quinine sulfate (QS), with good reproducibility and acceptable Stability and high selectivity, at the same time, effectively realize the simultaneous determination of dipyridamole and quinine sulfate, and solve the problems of complex and expensive detection methods of the two substances

Method used

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  • Molecularly imprinted electrochemical sensor based on FeS2/C/MQDs/GCE modified electrode and preparation method thereof
  • Molecularly imprinted electrochemical sensor based on FeS2/C/MQDs/GCE modified electrode and preparation method thereof
  • Molecularly imprinted electrochemical sensor based on FeS2/C/MQDs/GCE modified electrode and preparation method thereof

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Embodiment 1

[0041] FeS 2 Preparation of / C / MQDs / GCE Modified Electrode

[0042] FeS 2 / C and MQDs were synthesized according to the reported literature. Thereafter, 2mg of MQDs and 2mg of FeS 2 / C were dispersed in 1 mL of 0.2% chitosan-acetic acid solution (CS). 1.5 μL of MQDs solution was dropped onto the GCE and dried at 60 °C. Then add 7.5 μL of FeS 2 / C solution was dropped onto the obtained MQDs / GCE and dried at 60 °C to obtain FeS 2 / C / MQDs / GCE modified electrodes.

[0043] Based on FeS 2 Preparation of Molecularly Imprinted Electrochemical Sensors Using / C / MQDs / GCE Modified Electrodes

[0044] The modified electrode (FeS 2 / C / MQDs / GCE) were immersed in 0.01M phosphate buffer (PBS, pH 3.5) containing 1mM DIP, 1mM QS and 3mMβ-CD as functional monomers, and then the modified electrode was immersed in it, and the three-electrode system CV electrode Polymerized to FeS 2 / C / MQDs / MIP / GCE. The electropolymerization potential range is -0.1-0.9V, the number of polymerization cyc...

Embodiment 2

[0046] 2.4 Characterization of nanomaterials

[0047] During the preparation of the modified electrodes, SEM and TEM were used to characterize the morphology of the composite nanomaterials. From figure 1 The TEM in A shows that the MQDs are uniformly dispersed with an average size of about 3 nm. HRTEM image ( figure 1 Inset in A) shows the lattice properties of MQD particles. The lattice spacing is 0.23 nm, which corresponds to the 008 crystal plane of the MQDs. Meanwhile, Fourier transform infrared spectroscopy (FTIR) was used to characterize the types of functional groups on the surface of MQDs. Such as figure 1 As shown in B, functional groups such as -OH, -NH, -C=O, -C-F and Ti-O were observed, respectively. MQD at 3105cm -1 The vibration at is attributed to the -NH group, which indicates that the surface of the MQD is passivated by the -NH group. It is precisely because of the existence of these functional groups that it is more conducive to the subsequent combina...

Embodiment 3

[0055] In order to improve the measurement performance of imprinted nanocomposites, a series of experimental factors such as the molar ratio of template to monomer, number of polymerization cycles, pH value, elution and incubation time, and scanning rate were investigated respectively. By fabricating FeS under single factor parameters 2 / C / MQDs / MIP / GCE, the electrochemical response of DIP and QS was measured by DPV in PBS (pH 3.5) buffer containing a mixture of 40 μM DIP and QS. The results of the optimization part are shown below.

[0056] The number and intensity of molecularly imprinted cavities formed by CV electropolymerization are related to the ratio of template molecules to functional monomers. Such as Figure 6 As shown in A, between 1:1:0.5-1:1:7, when the ratio of template to functional monomer is 1:1:3, the peak current response is the strongest. Therefore, the optimal molar ratio of the template molecules DIP and QS to the functional monomer is 1:1:3. In addit...

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Abstract

The invention provides a molecularly imprinted electrochemical sensor based on a FeS2 / C / MQDs / GCE modified electrode and a preparation method thereof, and the preparation method of the FeS2 / C / MQDs / GCE modified electrode sequentially comprises the following steps: respectively dispersing MQDs and FeS2 / C in a chitosan-acetic acid solution; the MQDs solution is dropwise added to GCE, drying is performed, and MQDs / GCE is obtained; and dropwise adding the FeS2 / C solution onto the MQDs / GCE, and drying to obtain the FeS2 / C / MQDs / GCE modified electrode. The invention also comprises the modified electrode prepared by the method, a molecularly imprinted electrochemical sensor based on the modified electrode, and a preparation method and application of the molecularly imprinted electrochemical sensor. The method has good reproducibility, acceptable stability and high selectivity, meanwhile, the simultaneous determination of the dipyridamole and the quinine sulfate is effectively realized, and the problems that the detection mode of the dipyridamole and the quinine sulfate is complex and expensive and the like are solved.

Description

technical field [0001] The invention belongs to the technical field of double-template molecularly imprinted electrochemical sensors, in particular to a sensor based on FeS 2 Molecularly imprinted electrochemical sensor with / C / MQDs / GCE modified electrode and its preparation method and application. Background technique [0002] Dipyridamole (DIP), a coronary artery dilating and antithrombotic drug, is widely used in the treatment of cardiovascular diseases and can also be used to control the proliferation of cancer cells. However, uncontrolled use of DIP can lead to psychiatric disorders and serious secondary effects, with serious health risks. At the same time, DIP can also act as a doping agent in sports, causing deceptive results in sports situations. Therefore, the standardized use of DIP is of great significance in medical and sports events. Quinine sulfate (QS) is a quinoline derivative that can bind to the DNA of Plasmodium to form a complex to inhibit DNA replicat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/327
CPCG01N27/3277Y02A50/30
Inventor 鲁志伟孙萌萌李婷王妍媖饶含兵杜鑫
Owner SICHUAN AGRI UNIV
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