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Sampling swab rapid detection method and swab sampling fully integrated analysis system

An analysis system and fully integrated technology, applied in biochemical equipment and methods, microbial determination/inspection, application, etc., can solve problems such as limiting the application of nucleic acid detection of new coronavirus infection, affecting the process of solving new coronavirus infection, etc. The effect of reducing manual operation steps and labor intensity, avoiding manual operation errors, and reducing dosage

Active Publication Date: 2022-07-26
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This not only seriously affects the solution process of rapid detection and diagnosis of new coronavirus infection health and epidemic prevention that the world is facing today, but also seriously limits the application experimental scenarios of new coronavirus infection nucleic acid detection

Method used

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  • Sampling swab rapid detection method and swab sampling fully integrated analysis system
  • Sampling swab rapid detection method and swab sampling fully integrated analysis system
  • Sampling swab rapid detection method and swab sampling fully integrated analysis system

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] like figure 1 As shown, the fully integrated analysis system for swab sampling provided in this embodiment includes a preprocessing unit 1 , a mixing unit 2 , a sample dividing and amplification unit 3 , an optical detection unit 4 , a temperature control unit 5 and a motion control unit 6 .

[0077] The preprocessing unit 1 is configured to store the sampling swab, elute the substance to be detected on the sampling swab, and lyse and separate the nucleic acid;

[0078] The mixing unit 2 is configured to evenly mix the nucleic acid separated from the sampling swab with the reaction reagent;

[0079] The sample-dividing amplification unit 3 is configured to distribute the mixture of samples and reagents to each independent detection unit to realize multi-channel nucleic acid parallel amplification;

[0080] The optical detection unit 4 is configured to detect the sample-division and amplification unit 3 by one-time imaging; or to detect the sample-division and amplific...

Embodiment 2

[0106] The sampling swab provided in this embodiment is directly put into the rapid detection method, which includes the following steps:

[0107] S1. Put the sampling swab SZ into the preservation tube PC pre-installed with the inactivated lysis preservation solution PC4 to prevent RNA degradation, tighten the sealing cap PC2, and put the preservation tube PC with the sampling swab into the fully integrated The analysis system is started, wherein the pathogenic bacteria adhered on the sampling swab SZ are inactivated by the lysing preservation solution PC4, and the nucleic acid (DNA, RNA) is fixed without degradation;

[0108] S2. Under the action of the rotating motor M1, through the high-speed rotation of the crushing rod PC3, under the action of the rotating shear force, the substance to be detected on the sampling swab SZ is eluted, and under the action of the heating and extrusion unit, the mechanical One or more of the methods of fragmentation, thermal cracking or chemi...

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Abstract

The invention relates to a rapid detection method for sampling swabs and a fully integrated analysis system for swab sampling. The system includes a preprocessing unit, which is configured to store, elute, and lyse the sampling swabs to separate nucleic acids; a mixing unit is configured to In order to evenly mix the nucleic acid separated from the cleavage with the reaction reagent; the sample-division amplification unit is configured to distribute the mixture of the sample and the reaction reagent to each detection unit to realize multi-channel nucleic acid parallel amplification; the optical detection unit is configured to The nucleic acid amplification result of the sample dividing and amplification unit is detected; the temperature control unit is configured to perform heating and temperature control on the preprocessing unit and the sample dividing and amplification unit; and the motion control unit is configured to The movement of the processing unit, the mixing unit and the sample dividing and amplification unit is controlled; the signal storage processing and analysis unit, the wired or wireless communication interface, the display terminal and the cloud big data server. The swab of the present invention is put into a storage tube at one time after sampling, and the cover is no longer opened, and the whole process is sealed, which effectively avoids problems such as infection of subsequent operators and cross-contamination in the whole process.

Description

technical field [0001] The invention relates to the technical field of swab sampling biomedicine, in particular to a rapid detection method for sampling swabs and a fully integrated analysis system for swab sampling. Background technique [0002] Swab sampling is widely used in biomedical research, clinical medicine, and health and epidemic prevention. The process of using conventional swab sampling is as follows: First, by artificial means, use swabs to repeatedly perform samples on the parts of the human body (such as throat, mouth, nasal cavity, ear canal, eyes, skin, vagina, anus or intestines, etc.) that need to be sampled. Scratch and rub to transfer the samples attached to the body parts to the swab; then, immerse the swab head in the special reagent of the swab storage tube, and wash the swab by manual back-and-forth or external force such as vibration and ultrasound. The sample adhered to the sub-head is eluted into the special reagent of the swab storage tube, and...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B10/00C12Q1/6844C12M1/34C12M1/38
CPCA61B10/00C12Q1/6844
Inventor 黄国亮符荣鑫吕文琦杜文莉单晓晖靳翔宇林雪
Owner TSINGHUA UNIV
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