Application of red algae polysaccharide as expression promoter of ceramide and preparation method thereof

A technology for expressing an enhancer and red algae polysaccharide, applied in the field of skin repair and maintenance, can solve the problems of limited effect of ceramide, high price of ceramide, etc., and achieve the effects of being conducive to absorption and utilization, low molecular weight and high biological activity

Pending Publication Date: 2021-11-05
INFINITUS (CHINA) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are few natural substances that can promote the expression of ceramide, and the de novo synthesis of ceramide in vitro is expensive, and the effect of external application of ceramide is limited. Therefore, it is necessary to develop products that can promote the body's own synthesis of ceramide One of the hotspots of ceramide research

Method used

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  • Application of red algae polysaccharide as expression promoter of ceramide and preparation method thereof
  • Application of red algae polysaccharide as expression promoter of ceramide and preparation method thereof
  • Application of red algae polysaccharide as expression promoter of ceramide and preparation method thereof

Examples

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Effect test

Embodiment 1

[0058] This embodiment provides a use of red algae polysaccharide as a ceramide expression promoter. The red algae polysaccharide is a small molecular weight red algae polysaccharide with a molecular weight of less than or equal to 100kDa, which can promote the expression of ceramide and increase the content of ceramide in skin cells, and can repair skin barrier damage and keep skin healthy. Preferably, the molecular weight of the red algae polysaccharide is (2.0-5.0) kDa to 50 kDa. It should be noted that the molecular weights mentioned in the present invention are all weight average molecular weights.

[0059] The low-molecular-weight red algae polysaccharide of the present invention is used as an accelerator, which can induce the expression of main enzymes involved in the ceramide synthesis and metabolism pathway, increase the activity of related enzymes, and thereby increase the content of ceramide in cells.

Embodiment 2

[0061] This example discloses the use of red algae polysaccharide in the preparation of cosmetics or external skin medicines with ceramide regulation effect. The red seaweed polysaccharide of the present invention has a low molecular weight, the molecular weight is less than or equal to 100kDa, preferably the molecular weight of the red seaweed polysaccharide is less than or equal to 50kDa. The red algae polysaccharide is a solid powder easily soluble in water, has good compatibility with various cosmetics or skin external drug excipients, and can conveniently prepare various dosage forms of cosmetics or skin external drug. Among them, the dosage forms of cosmetics include but are not limited to cream milk (ointment, cream, honey, fat, milk, emulsion, milk, milk), liquid (dew, liquid, water, oil, oil-water separation), gel (gel, glue), powder (loose powder, granule), block (lump powder, bulk solid), mud (mud-like solid), wax-based, spray, aerosol, paste / film (including base ma...

Embodiment 3

[0067] This example provides a method for preparing a small molecular weight red algal polysaccharide with a molecular weight less than or equal to 100kDa, which can be used to prepare a small molecular weight red algal polysaccharide with the use as in Example 1 or 2, including the following steps:

[0068] S1, crushing the dried product of red algae, and performing degreasing treatment with ethanol to obtain defatted red algae.

[0069] The specific process is that the dried red algae is crushed into a fine powder of 60 mesh to 100 mesh. Take the fine powder of red algae, add 5-10 times the amount of absolute ethanol to extract for 4h-12h, filter and shake off excess ethanol, and obtain the filter residue for later use.

[0070] In this example, the dried product of red algae used is Gracilaria produced in Rongcheng, Shandong, China. It should be noted that, in addition to the Gracilaria produced in Rongcheng, Shandong Province in this embodiment, the dried red algae produc...

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Abstract

The invention relates to application of red algae polysaccharide as an expression promoter of ceramide and a preparation method thereof. The molecular weight of the red algae polysaccharide is less than or equal to 100kDa. The red algae polysaccharide can induce the expression effect of the main enzymes involved in a ceramide anabolism pathway, so that the activity of the related enzymes is increased, and the effect of increasing the content of ceramide in cells is achieved. Therefore, when the cosmetics or the skin external medicine which is prepared from the red algae polysaccharide and has the ceramide regulation effect is smeared on the skin, the skin barrier repair can be promoted, and the expression of inflammatory factors in the skin can be inhibited. According to the preparation method of the red algae polysaccharide, the molecular weight of the obtained red algae polysaccharide can be accurately controlled by utilizing a process of combining subcritical extraction with enzyme hydrolysis treatment. Compared with a traditional hot water extraction or subcritical extraction process, the preparation method has the advantages that the extraction rate of the red algae polysaccharide can be increased, the red algae polysaccharide with the molecular weight smaller than or equal to 100 kDa can be prepared, and the heavy metal removal rate of the red algae polysaccharide can be increased.

Description

technical field [0001] The invention relates to the technical field of skin repair and maintenance, in particular to the use of red algae polysaccharide as a ceramide expression promoter and its preparation method. Background technique [0002] Ceramides, the breakdown products of sphingomyelin in the bilayer of biological membranes, are recognized second messengers. Ceramide is widely involved in the biological effects induced by various cytokines, vitamin D3, Fas and CD28 ligands. Ceramide can induce apoptosis, induce cell differentiation, and inhibit cell proliferation in cells, so it can be used for symptomatic treatment of diseases such as long-term inflammation and malignant tumors caused by abnormal cell proliferation or differentiation. [0003] Ceramides account for more than half of the lipids in the outermost stratum corneum of the skin and play an important protective role in the barrier structure of the skin. The lack of ceramide in the stratum corneum of the ...

Claims

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Application Information

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IPC IPC(8): A61K8/73A61Q19/00A61K31/715A61K36/04A61P17/00C08B37/00
CPCA61K8/73A61Q19/00A61K31/715A61K36/04A61K9/0014A61P17/00C08B37/0003A61K2800/78
Inventor 敢小双太美灵杜志云韩萍林丽
Owner INFINITUS (CHINA) CO LTD
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