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In-situ polymerization strong-adhesion antibacterial hemostatic hydrogel, and preparation method and application thereof

An in-situ polymerization and hydrogel technology, applied in applications, pharmaceutical formulations, surgical adhesives, etc., can solve the problems of lack of antibacterial properties and low swelling rate, and achieve high tissue adhesion, enhanced mechanical strength, and excellent hemostasis The effect of the antibacterial effect

Pending Publication Date: 2021-11-12
SHANGHAI CHANGZHENG HOSPITAL +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The patent discloses a double network hydrogel that does not swell very well and additionally lacks antimicrobial properties

Method used

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  • In-situ polymerization strong-adhesion antibacterial hemostatic hydrogel, and preparation method and application thereof
  • In-situ polymerization strong-adhesion antibacterial hemostatic hydrogel, and preparation method and application thereof
  • In-situ polymerization strong-adhesion antibacterial hemostatic hydrogel, and preparation method and application thereof

Examples

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preparation example Construction

[0068] The present invention firstly provides a method for preparing an antibacterial and hemostatic hydrogel with in-situ polymerization and strong adhesion, comprising the following steps:

[0069] (1) Add gelatin to deionized water, heat and stir to make it evenly dispersed, add a certain proportion of methacrylic anhydride at a certain temperature, stir and mix evenly, continue to react for a period of time, move to a dialysis bag for dialysis purification, and The dialyzed solution was freeze-dried to obtain GelMA, and then the GelMA was stored at -20°C for future use.

[0070] (2) Disperse dextran in deionized water, heat and stir to disperse evenly, then add a certain amount of oxidant, stir to fully dissolve, mix evenly, oxidize for a period of time in the dark, dialyze and the obtained product is oxidized dextran powdered sugar.

[0071] (3) Disperse GelMA into deionized water, heat and stir to fully dissolve, then add OD, continue stirring to fully dissolve, add Bor...

Embodiment 1

[0085] The preparation method of GelMA / OD / Borax triple network hydrogel in this example is as follows:

[0086] (1) Type A gelatin was dissolved in deionized water and magnetically stirred at 50° C. to obtain a 10% w / v homogeneous solution. Then, drop MA into the gelatin solution with a micro-syringe pump at an injection rate of 0.5 mL / min. The final ratio of MA to gelatin was 0.1 mL / 1 g. Rapid stirring was continued for 4 hours at 50°C. The resulting solution was dialyzed against deionized water at 50 °C for 4 days using a dialysis bag with a molecular weight cut-off of 14 kDa to remove unreacted MA and other by-products. After dialysis, the GelMA solution was frozen at -50°C for 24 hours, then lyophilized and stored at -20°C until use. Depend on image 3 a It can be seen that the successful synthesis of GelMA was verified by proton nuclear magnetic resonance spectroscopy.

[0087] (2) Dissolve 10 g of dextran (0.0618 mol) in 200 mL of distilled water, and stir magnetica...

Embodiment 2

[0091] The difference between the preparation method of the GelMA / OD / Borax triple network hydrogel in this example and Example 1 is that in step 3), the mass ratio of GelMA:OD is 1:1 and mixed evenly, and the rest are the same as in Example 1. of the same.

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Abstract

The invention relates to an in-situ polymerization strong-adhesion antibacterial hemostatic hydrogel, and a preparation method and application thereof. The preparation method comprises the following steps of : uniformly stirring and mixing gelatin and methacrylic anhydride in a biocompatible medium, and reacting to obtain GelMA; dispersing dextran in a biocompatible medium, adding an oxidant, and oxidizing in a dark place to obtain a product, i.e., oxidized dextran; dispersing the GelMA into a biological compatilizer medium, adding oxidized dextran, sodium tetraborate and a photoinitiator, and finally obtaining a GelMA / OD / Borax hydrogel precursor solution; and under the initiation of ultraviolet light, polymerizing the GelMA / OD / Borax hydrogel precursor solution to obtain a GelMA / OD / Borax triple network hydrogel. Compared with the prior art, the GelMA / OD / Borax hydrogel prepared by the invention is the triple network hydrogel, has good mechanical properties and has biocompatibility in cell and animal levels, meanwhile, the GelMA / OD / Borax hydrogel has a high tissue adhesion ability, antibacterial ability and tensile and compressive ability, and is expected to be applied to the field of hemostasis of arteriole, heart, liver and other viscera.

Description

technical field [0001] The invention belongs to the field of hydrogel materials, and in particular relates to an antibacterial hemostatic hydrogel with in-situ polymerization and strong adhesion, a preparation method and application thereof. Background technique [0002] Acute hemorrhage and associated wound infections remain one of the leading causes of death worldwide, not only on the modern battlefield but also in everyday life. Ruptured internal arteries are often accompanied by uncontrollable hemorrhage, characterized by rapid blood flow, high blood pressure, and difficulty in self-healing wounds. If the bleeding is not stopped in time, the lives of the wounded will be seriously endangered. Therefore, whether the bleeding can be effectively controlled is very important to improve the survival rate of the wounded. Hemostasis is the mainstay of treatment for organ ruptures and penetrating wounds. Currently, surgical sutures are the main method for closing aortic rupture...

Claims

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Application Information

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IPC IPC(8): A61L24/10A61L24/02A61L24/08A61L24/00C08J3/075C08J3/24C08L89/00C08L5/02
CPCA61L24/0031A61L24/104A61L24/08A61L24/02A61L24/0015C08J3/075C08J3/246A61L2400/04A61L2300/404C08J2389/00C08J2305/02C08J2489/00C08J2405/02
Inventor 王海滨陈政卢旭华王世革杨海松王亮
Owner SHANGHAI CHANGZHENG HOSPITAL
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