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Fisetin phospholipid complex, weight-reducing medicine/health food and application thereof

A technology of fisetin phospholipids and health food, applied in application, food ingredients, drug combination, etc., can solve the problems of poor water solubility and bioavailability of fisetin, so as to improve the poor metabolism of the body and increase sensitivity , The effect of improving bioavailability

Pending Publication Date: 2021-11-19
CHONGQING UNIV OF EDUCATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The fisetin phospholipid complex uses the characteristic of leptin sensitization effect of fisetin, as a weight loss product, long-term use will not cause liver damage and side effects of decreased immunity, and the fisetin phospholipid complex also overcomes the Technical problems of poor water solubility and bioavailability of fisetin

Method used

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  • Fisetin phospholipid complex, weight-reducing medicine/health food and application thereof
  • Fisetin phospholipid complex, weight-reducing medicine/health food and application thereof
  • Fisetin phospholipid complex, weight-reducing medicine/health food and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Embodiment 1: Preparation of fisetin nanocrystals

[0053] Dissolve 4% poloxamer 188 (P 188) and 0.5% copovidone S 630 in 50ml purified water, stir until completely dissolved, add 1% propyl gallate (PG), stir until completely dissolved, spare. Take 46g of the mixed solution and 4g of fisetin, put them into a grinding tank, add grinding balls, grind for 200min, sieve and separate the fisetin nano-suspension, add 5% mannitol, put it into a freeze dryer Pre-freeze for 24 hours, and then dry to obtain fisetin nanocrystals.

[0054] The solubility of the fisetin nano-crystal freeze-dried product in phosphate buffer (pH=6.8) was determined. Aspirate phosphate buffer (pH=6.8) and 0.5% Tween 80 solution respectively, add excess fisetin and fisetin nano-crystal freeze-dried product, vortex continuously for 48 hours, centrifuge and take supernatant 2mL , filtered with a 0.22 μm microporous membrane, and the absorbance was measured after the release medium was diluted, and the ...

Embodiment 2

[0057] Embodiment 2: the preparation of fisetin phospholipid complex

[0058] Dissolve 300mg fisetin and 1.2g soybean lecithin in 30ml tetrahydrofuran, and react under reflux magnetic stirring for 2h at 40°C. After the reaction, the reaction solution was distilled off under reduced pressure to remove the reaction solvent, an appropriate amount of chloroform was added, and the filtrate was filtered with suction, and the filtrate was distilled off under reduced pressure to remove the chloroform, and dried in vacuo at 40°C for 3 hours to obtain a solid fisetin-phospholipid complex. The solubility of the complex in n-octanol and water is shown in Table 2, and the solubility is increased by about 9 times and 8 times, respectively.

[0059] Table 2 Solubility of fisetin and its phospholipid complex in n-octanol and water

[0060]

Embodiment 3

[0061] The preparation of embodiment 3 fisetin-cyclodextrin complex

[0062] Add 0.286g fisetin and 1.38g β-cyclodextrin (β-CD) into 25ml of pure water, shake in a water bath at 30°C for 72 hours, centrifuge to obtain a supernatant, add 5% mannitol, put Pre-freeze in a freeze dryer for 24 hours, and then dry to obtain the fisetin / cyclodextrin complex. The solubility of the complex in water is shown in Table 3, and the solubility is increased by 9 times.

[0063] Table 3 Solubility of fisetin and fisetin / cyclodextrin complex in water

[0064] sample Apparent solubility mg / ml Fisetin 0.15 Fisetin / cyclodextrin complex 1.32

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Abstract

The invention belongs to the field of traditional Chinese medicine preparations / health-care foods, and particularly relates to a fisetin phospholipid complex, a weight-reducing medicine / health-care food and an application thereof. The preparation method comprises the following steps: dissolving fisetin and phospholipid in an organic solvent, and reacting to prepare the fisetin-phospholipid complex; and the weight-reducing medicine / health food is prepared from 10-50% of fisetin and / or fisetin phospholipid complex and / or fisetin nanocrystals and / or fisetin cyclodextrin complex, 10-50% of a fructus lycii extract, 10-50% of a semen cassiae extract, 10-50% of a lalang grass rhizome extract and 10-50% of a radix astragali seu hedysari extract. According to the fisetin phospholipid complex and the weight-reducing medicine / health food provided by the invention, the water solubility of fisetin is improved by 10 times, the bioavailability is improved by 230%, and the fisetin phospholipid complex and the weight-reducing medicine / health-care food have a good weight-reducing effect, can relieve liver injury caused by metabolic stress while reducing weight, and are high in safety.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations / health food, and specifically relates to a fisetin phospholipid complex, weight loss medicine / health food and applications thereof. Background technique [0002] Currently recognized effective weight loss drugs are L-carnitine, sibutramine, orlistat and so on. L-carnitine can strengthen fat metabolism, reduce the consumption of glycogen, promote the entry of fat and fatty acid, and increase the oxidation rate of fat. Sibutramine is a non-amphetamine appetite suppressant. It produces metabolites in the body, which can inhibit the reuptake of norepinephrine, serotonin and dopamine, accelerate energy consumption and increase satiety. Osreliv acts on the gastrointestinal tract, by inhibiting the lipase in the gastrointestinal tract, preventing the hydrolysis of triacylglycerol into free fatty acids and monoacylglycerides, reducing the absorption of dietary fat by the intestina...

Claims

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Application Information

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IPC IPC(8): A61K47/54A61K31/352A23L33/105A61K36/899A61P3/04
CPCA61K47/544A61K31/352A61K36/815A61K36/482A61K36/899A61K36/481A61P3/04A23L33/105A23V2002/00A61K2300/00A23V2200/332A23V2250/2116
Inventor 谭君徐敏轩葛晨旭况琴代先玲
Owner CHONGQING UNIV OF EDUCATION
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