Preparation method of sodium copper chlorophyllin

Abstract

The invention belongs to the technical field of separation and extraction of active ingredients of natural products, and particularly relates to a preparation method of sodium copper chlorophyllin. The preparation method of sodium copper chlorophyllin comprises the steps of S1, carrying out saponification, specifically, taking pasty chlorophyll, adding a NaOH aqueous solution, keeping the constant temperature at 55 DEG C, and electrically stirring and saponifying for 6 hours; S2, carrying out separation, specifically, after saponification is completed, continuously adding 1BV pure water, stirring until the pure water is uniformly dissolved, centrifuging by using a high-speed centrifugal machine, precipitating saponified insoluble substances at the bottom of the centrifugal machine after centrifuging, and taking supernatant for copper placement; S3, conducting copper placement, specifically, adding CuSO4 accounting for 5% of the mass of the viscous paste, dissolving the CuSO4 in 5BV water, and stirring at the constant temperature of 50 DEG C while adding a CuSO4 aqueous solution for copper substitution for 2.5 hours; and S4, performing precipitation and purification, specifically, filtering the filtrate by using a hollow fiber membrane, concentrating, and detecting. The method has the characteristics that the production efficiency is high, the environment is protected, the sodium copper chlorophyllin can be prepared without refining and purifying an organic solvent, and the production cost is greatly reduced.

Description

technical field [0001] The invention belongs to the technical field of separation and extraction of active ingredients of natural products, and in particular relates to a preparation method of sodium copper chlorophyllin. Background technique [0002] The traditional process of preparing copper chlorophyllin sodium salt from sticky chlorophyll is: sticky chlorophyll is saponified by adding alkali in acetone and ethanol, or first saponified by adding alkali, then washing with acetone → adding copper sulfate to place copper → using acid water, ethanol, Washing with acetone, ether, gasoline, etc. to remove impurities → Concentrate and dry the finished product. Among them, there are invention patents "Patent No. ZL200710061547.2" and "Patent No. ZL01128942.2". In the process of saponification, ethanol and acetone are used to repeatedly wash and remove impurities. Wait for further washing and purification to make its color value finally meet the national standard requirements. ...

AI Technical Summary

Problems solved by technology

Traditional method has following shortcoming: 1, need to use a large amount of organic solvents (acetone, ethanol etc.) to carry out saponification separation, and carry out organic solvent (ethanol, acetone, ether, gasoline etc.) washing with copper chlorophyllin sodium salt behind the copper, The cost of organic solvent is high, the loss of concentration recovery is large, and the heat energy consumption is large

2. The use of organic solvents for washing and purification requires standing and settling, and the settling time is too long, which affects production efficiency

3. The conversion rate of color value is low. Due to solvent washing and purification, the critical point of washing is not easy to control. Sometimes a large amount of pigment is washed down as waste liquid, and sometimes the washing is not sufficient, and the color value after salt formation cannot meet the national standard requirements.

4. Due to the use of a large amount of organic solvents, there are high requirements for the operating environment (need to be equipped with corresponding organic solvent alarms, etc.), and the operators will be more or less exposed to organic solvents, which is not conducive to the health of the operators

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