A kind of preparation method of chlorophyll copper sodium salt

Abstract

The invention belongs to the technical field of separation and extraction of active ingredients of natural products, and in particular relates to a preparation method of copper chlorophyll sodium salt; a preparation method of copper chlorophyll sodium salt, comprising the following steps: S1, saponification: taking viscous paste chlorophyll, adding NaOH aqueous solution, keep the constant temperature of 55 ℃ for saponification with electric stirring for 6h; S2, separation: after the saponification is completed, continue to add 1BV pure water and stir until the dissolution is uniform, and centrifuge with a high-speed centrifuge. liquid to set copper; S3, set copper: add CuSO with 5% mass of viscous paste 4 , dissolved in 5BV water, while adding CuSO 4 The aqueous solution is stirred at a constant temperature of 50 °C for 2.5 hours; S4, precipitation purification: take the filtrate and filter it with a hollow fiber membrane, then concentrate it, and test it; using this method has the advantages of high production efficiency, environmental protection, and no purification and purification with organic solvents. The chlorophyll copper sodium salt is prepared, and the production cost is greatly reduced.

Description

technical field [0001] The invention belongs to the technical field of separation and extraction of active ingredients of natural products, and particularly relates to a preparation method of copper chlorophyll sodium salt. Background technique [0002] The traditional process of using sticky chlorophyll to prepare copper chlorophyll sodium salt is as follows: sticky chlorophyll is saponified by adding alkali in acetone and ethanol, or first adding alkali saponification, then washing with acetone → adding copper sulfate and placing copper → using acid water, ethanol, Acetone, ether, gasoline, etc. are washed to remove impurities → concentrated and dried finished products. Among them, there are invention patents "Patent No. ZL200710061547.2" and "Patent No. ZL01128942.2", in the process of saponification, ethanol and acetone are used to repeatedly wash and remove impurities. After copper is placed, ethanol or (or acetone), gasoline, ether Wait for further washing and purific...

AI Technical Summary

Problems solved by technology

Traditional method has following shortcoming: 1, need to use a large amount of organic solvents (acetone, ethanol etc.) to carry out saponification separation, and carry out organic solvent (ethanol, acetone, ether, gasoline etc.) washing with copper chlorophyllin sodium salt behind the copper, The cost of organic solvent is high, the loss of concentration recovery is large, and the heat energy consumption is large

2. The use of organic solvents for washing and purification requires standing and settling, and the settling time is too long, which affects production efficiency

3. The conversion rate of color value is low. Due to solvent washing and purification, the critical point of washing is not easy to control. Sometimes a large amount of pigment is washed down as waste liquid, and sometimes the washing is not sufficient, and the color value after salt formation cannot meet the national standard requirements.

4. Due to the use of a large amount of organic solvents, there are high requirements for the operating environment (need to be equipped with corresponding organic solvent alarms, etc.), and the operators will be more or less exposed to organic solvents, which is not conducive to the health of the operators

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