Thermal response type bornyl steam instant micro-needle eye mask and preparation method and application thereof

A borneol-based, thermally responsive technology, applied in microneedles, needles, pharmaceutical formulations, etc., can solve problems that have not yet been discovered, and achieve the effects of improving bioavailability, accelerating microcirculation, and improving user comfort.

Active Publication Date: 2021-12-17
华工新颜(深圳)科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, although many patents have reported that d-borneol and other substances synergize to achieve twice the result with half the effort, however, no use has been found to control the external temperature. Related patent reports on the technology of preparing heat-responsive instant microneedle eye patch to solve eye skin problems

Method used

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  • Thermal response type bornyl steam instant micro-needle eye mask and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] The thermally responsive borneol-based steam instant microneedle eye patch for relieving eye problems in this embodiment includes the following components by mass percentage:

[0052] Needle base solution: nicotinamide 0.5%, carnosine 0.1%, arbutin 2%, tranexamic acid 0.5%, VC-ethyl ether 0.2%, acetyl hexapeptide-8 2%, palmitoyl pentapeptide-4 1 %, Palmitoyl Tetrapeptide-7 2%, Phytosterol 1%, Hydroxypropyl Tetrahydropyrantriol 0.5%, Fibronectin 1%, Sodium Tocopheryl Phosphate 0.4%, Silk Extract 3%, Natural Right Spiral borneol 0.2%, PEG-40 hydrogenated castor oil 0.8%, Glycyrrhiza glabra root extract 4%, hyaluronic acid 5%, and the balance is deionized water.

[0053] Lining matrix solution: needle body matrix solution 30%, hyaluronic acid 8%, polyvinylpyrrolidone 5%, and the balance is deionized water.

[0054] Intermediate sustained-release layer solution: borneol essential oil 50%, sweet orange essential oil 30%, lavender essential oil 3%, green tea essential oil 5%...

Embodiment 2

[0071] The thermally responsive borneol-based steam instant microneedle eye patch for relieving eye problems in this embodiment includes the following components by mass percentage:

[0072] Needle base solution: nicotinamide 0.8%, carnosine 0.2%, arbutin 1%, tranexamic acid 1%, VC-ethyl ether 0.1%, acetyl hexapeptide-8 3%, palmitoyl pentapeptide-4 2 %, Palmitoyl Tetrapeptide-7 1%, Phytosterol 1.5%, Hydroxypropyl Tetrahydropyrantriol 0.6%, Fibronectin 2%, Sodium Tocopheryl Phosphate 0.5%, Silk Extract 2.5%, Natural Right Spiral borneol 0.5%, PEG-40 hydrogenated castor oil 2%, Glycyrrhiza glabra root extract 2%, hyaluronic acid 6%, and the balance is deionized water.

[0073] Lining matrix solution: needle body matrix solution 30%, hyaluronic acid 5%, polyvinyl alcohol 8%, and the balance is deionized water.

[0074] Intermediate sustained-release layer solution: borneol essential oil 60%, sweet orange essential oil 13%, green tea essential oil 20%, polyglycerol-2 sesquiisoste...

Embodiment 3

[0091] The thermally responsive borneol-based steam instant microneedle eye patch for relieving eye problems in this embodiment includes the following components by mass percentage:

[0092] Needle base solution: niacinamide 1%, carnosine 0.3%, arbutin 0.5%, tranexamic acid 1.5%, VC-ethyl ether 0.5%, acetyl hexapeptide-8 5%, palmitoyl pentapeptide-4 3 %, Palmitoyl Tetrapeptide-7 2%, Phytosterol 0.5%, Hydroxypropyl Tetrahydropyrantriol 0.3%, Fibronectin 3%, Sodium Tocopheryl Phosphate 0.8%, Silk Extract 0.5%, Natural Right Spiral borneol 1%, PEG-40 hydrogenated castor oil 4%, Glycyrrhiza glabra root extract 3%, hyaluronic acid 3%, and the balance is deionized water.

[0093] Lining matrix solution: needle body matrix solution 30%, hyaluronic acid 10%, polyvinyl alcohol 5%, polyvinylpyrrolidone 2%, and the balance is deionized water.

[0094] Intermediate sustained-release layer solution: borneol essential oil 30%, rose essential oil 30%, sweet orange essential oil 24%, green t...

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Abstract

The invention discloses a thermal response type bornyl steam instant micro-needle eye mask and a preparation method and application thereof. The eye mask comprises a micro-needle layer, a middle slow release layer and a heating layer which are connected in sequence, wherein the micro-needle layer contains natural d-borneol. The micro-needle layer takes the natural d-borneol as a penetration enhancer, so that functional components are rapidly absorbed by skin cells, and the using effect of a micro-needle is remarkably enhanced; the heating layer is contained, so that the micro-needle can be heated, the bioavailability of the functional components is improved, the puncture feeling and pain feeling of the micro-needle can be remarkably reduced, the using comfort of the micro-needle is improved, the internal microcirculation of skin can be accelerated, the absorption of the functional components is promoted, and the dissolution rate of the micro-needle is increased; and the middle slow release layer is rich in water-in-oil micro-emulsion, essential oil and moisture in the micro-emulsion can generate steam in the heating process, and the steam can enter the skin through the micro-needle, so that on one hand, the skin moisture is supplemented, and the dissolution of the micro-needle is accelerated, and on the other hand, the essential oil can achieve the effects of awakening the skin vitality, enhancing the skin tolerance and keeping the skin in an optimal state.

Description

technical field [0001] The invention relates to the technical field of eye cosmetics, in particular to a thermally responsive borneol-based steam instant microneedle eye patch and a preparation method and application thereof. Background technique [0002] With the development of the country, people's living standards have been continuously improved, and material conditions have become prosperous. People began to urgently pursue spiritual and cultural life, especially for women, the emphasis on personal appearance has reached an unprecedented level. Of course, a good appearance is one of the important conditions for satisfying a person's spiritual pursuit. However, the fast pace of the new era conflicts with the exquisite life people pursue, and "busyness" has become an eternal topic for people. Frequent overtime work makes people generally have no time to take care of their personal makeup, and under high pressure for a long time, people tend to have anxiety, anxiety and ot...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9789A61K8/92A61K8/67A61K8/44A61K8/68A61K8/49A61K8/58A61K8/64A61K8/63A61K8/60A61K8/34A61K8/02A61Q19/00A61H33/06A61M37/00
CPCA61K8/9789A61K8/922A61K8/678A61K8/676A61K8/44A61K8/68A61K8/675A61K8/4946A61K8/498A61K8/585A61K8/64A61K8/63A61K8/602A61K8/34A61K8/0208A61Q19/005A61H33/06A61M37/0015A61K2800/592A61H2033/068A61H2205/024A61M2037/0046A61M2037/0053A61M2037/0007
Inventor 范鹏辉苏健裕王炎骄吕满霞侯玉超
Owner 华工新颜(深圳)科技有限公司
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