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Medical catheter surface modification method giving consideration to hydrophilicity, low friction and bacterial adhesion resistance and application

An anti-bacterial adhesion, medical catheter technology, applied in catheters, pharmaceutical formulations, coatings, etc., can solve the problems of untested anti-bacterial adhesion performance, high cost, low graft density, etc., and achieve anti-bacterial adhesion improvement. method, high firmness, low friction effect

Inactive Publication Date: 2021-12-21
康健仿生清远科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The coating uses vinyl zwitterionic monomers, which are expensive; the use of zwitterionic secondary functional modification may result in low graft density, which is not reflected in the examples, and the anti-bacterial adhesion performance was not tested

Method used

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  • Medical catheter surface modification method giving consideration to hydrophilicity, low friction and bacterial adhesion resistance and application
  • Medical catheter surface modification method giving consideration to hydrophilicity, low friction and bacterial adhesion resistance and application
  • Medical catheter surface modification method giving consideration to hydrophilicity, low friction and bacterial adhesion resistance and application

Examples

Experimental program
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Effect test

Embodiment 1

[0030] see Figure 1-Figure 2 , the present invention provides the following technical solutions: a method for modifying the surface of a medical catheter and its application taking into account hydrophilicity, low friction, and anti-bacterial adhesion, comprising the following steps:

[0031] Step 1: Preparation of phosphorylcholined polyvinylamine PVAm-PC: first add polyvinylamine PVAm and aldylated glycerophosphorylcholine PCGA into methanol solution, wherein the molar ratio of PVAm to PCGA is 1:2, fully stir to dissolve , react at 40°C for 16h, then add sodium cyanoborohydride NaBH at 0°C 3 CN, fully stirred and dissolved, heated to room temperature and reacted for 24 hours, dialyzed (molecular weight cut-off 500) for 3 days after the reaction, and freeze-dried to obtain PVAm-PC, wherein the substitution degree of PC was 30%;

[0032] Step 2: Preparation of silica sol: fully stir acetic acid, tetraethyl silicate TEOS, deionized water and ethylene glycol monomethyl ether, ...

Embodiment 2

[0040] see Figure 1-Figure 2 , the present invention provides the following technical solutions: a method for modifying the surface of a medical catheter and its application taking into account hydrophilicity, low friction, and anti-bacterial adhesion, comprising the following steps:

[0041] Step 1: Preparation of phosphorylcholined polyvinylamine PVAm-PC: first add polyvinylamine PVAm and aldylated glycerophosphorylcholine PCGA into methanol solution, wherein the molar ratio of PVAm to PCGA is 1:2, fully stir to dissolve , react at 55°C for 24h, then add sodium cyanoborohydride NaBH at 0°C 3 CN, fully stirred to dissolve, heated to room temperature to react for 24 hours, dialyzed (MWCO 500) for 3 days after the reaction, and freeze-dried to obtain PVAm-PC, wherein the substitution degree of PC was 40%;

[0042] Step 2: Preparation of silica sol: fully stir acetic acid, tetraethyl silicate TEOS, deionized water and ethylene glycol monomethyl ether, wherein acetic acid, tetr...

Embodiment 3

[0050] see Figure 1-Figure 2 , the present invention provides the following technical solutions: a method for modifying the surface of a medical catheter and its application taking into account hydrophilicity, low friction, and anti-bacterial adhesion, comprising the following steps:

[0051] Step 1: Preparation of phosphorylcholined polyvinylamine PVAm-PC: first add polyvinylamine PVAm and aldylated glycerophosphorylcholine PCGA into methanol solution, wherein the molar ratio of PVAm to PCGA is 1:4, fully stir to dissolve , react at 55°C for 24h, then add sodium cyanoborohydride NaBH at 0°C 3 CN, fully stirred and dissolved, heated to room temperature and reacted for 24 hours, dialyzed (molecular weight cut-off 500) for 3 days after the reaction, and freeze-dried to obtain PVAm-PC, wherein the substitution degree of PC was 50%;

[0052] Step 2: Preparation of silica sol: fully stir acetic acid, tetraethyl silicate TEOS, deionized water and ethylene glycol monomethyl ether, ...

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Abstract

The invention belongs to the technical field of material surface modification, and particularly relates to a medical catheter surface modification method giving consideration to hydrophilicity, low friction and bacterial adhesion resistance and application, and the method comprises the following steps: preparing phosphorylated choline polyvinylamine (PVAm-PC); preparing silica sol; and preparing a super-hydrophilic, low-friction and antibacterial medical catheter: compounding the PVAm-PC and the silica sol according to a specified mass ratio, putting the medical catheter subjected to plasma treatment into a compound solution, and taking out the medical catheter after proper time. The surface modification method for the medical catheter with hydrophilicity, low friction and bacterial adhesion resistance is relatively simple, and a phosphorylcholine-based zwitterionic composite coating can be formed on the surface of the medical catheter; and the coating is high in firmness, has good flexibility, improves the hydrophilicity of the medical catheter, reduces the sliding friction force, and has good biocompatibility and antibacterial adhesion performance.

Description

technical field [0001] The invention belongs to the technical field of surface modification of materials, and in particular relates to a method for modifying the surface of a medical catheter and an application thereof taking into account hydrophilicity, low friction and anti-bacterial adhesion. Background technique [0002] With the continuous development of medical technology, medical catheters are widely used clinically. They can be divided into in vitro medical catheters and internal medical catheters. In vivo catheters can be divided into digestive system catheters, internal circulation catheters, and urinary system catheters. Medical catheters should have good biocompatibility, non-irritating and non-toxic to human tissues, and almost no rejection of the body, etc. At present, the materials used to prepare medical catheter products mainly include silicone rubber, polyethylene, Polyurethane and its copolymers, etc. In addition, medical catheters in the body need to be ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L29/16A61L29/14A61L29/08C08F8/40C08F26/02
CPCA61L29/16A61L29/085C08F8/40A61L29/14A61L2400/18A61L2420/04C08F26/02
Inventor 曾戎曹惠
Owner 康健仿生清远科技有限公司