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Metal organic framework nano-carrier as well as preparation method and application thereof

A metal-organic framework and nano-carrier technology, which is applied in the directions of organic active ingredients, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc. problem, to achieve the effect of increasing cycle time, simple synthesis, high ability to catalyze hydrogen peroxide

Pending Publication Date: 2022-01-18
SHENZHEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In view of the above-mentioned deficiencies in the prior art, the purpose of the present invention is to provide a metal organic framework nanocarrier and its preparation method and application, aiming to solve the problems of cumbersome steps and low production efficiency in the preparation of zirconium-based porphyrin metal organic frameworks by the oil bath heating method. The problem of low and low iron ion loading rate

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  • Metal organic framework nano-carrier as well as preparation method and application thereof
  • Metal organic framework nano-carrier as well as preparation method and application thereof
  • Metal organic framework nano-carrier as well as preparation method and application thereof

Examples

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Embodiment 1

[0060] Example 1: Preparation of an anti-tumor metal-organic framework nanocarrier for enhanced chemokinetic therapy

[0061] The steps for synthesizing PCN-224(Fe) by the traditional oil bath method are as follows: get 130mg zirconium chloride, 60mg TCPP, 1.4g benzoic acid, 60mL N,N-dimethylformamide (DMF) and mix under ultrasonic conditions to obtain a mixture solution, put the mixed solution into a flat-bottomed flask, and put it into a magnet, set the reaction temperature of the oil bath to 90°C, and the stirring speed of the magnet to 400rpm, and react for 5 hours; after the reaction is completed, in the solution after the reaction Add 100 mg of ferrous chloride, the temperature of the oil bath is 100 ° C, and the incubation time is 24 hours. The preliminary product is collected by centrifugation, washed 3 times with DMF, washed 1 time with ethanol, and dried to obtain the final product PCN-224 (Fe ).

[0062] The steps for synthesizing PCN-224(Fe)@PEG by microwave one-s...

Embodiment 2

[0067] Example 2: Preparation of an anti-tumor nano-drug containing lactate oxidase and pyruvate kinase inhibitors loaded with an anti-tumor metal-organic framework nanocarrier for enhanced chemokinetic therapy

[0068] Use 1-ethyl-(3-dimethylaminopropyl)carbodiimide (EDC) to activate the carboxyl group on lactate oxidase (LOx), the mass ratio is EDC:LOx=10:1, and the activation time is 1h Then add N-hydroxysuccinimide (NHS) and PCN-224 (Fe), wherein the mass ratio is NHS:PCN-224 (Fe)=1:1, adjust the pH to 6.8, and mix the reaction for 6h to realize the amidation reaction , the product was collected by centrifugation, washed three times with ethanol, and dried to obtain PCN-224(Fe)-LOx nanoparticles.

[0069] TEPP-46@PCN-224(Fe) nanoparticles were directly prepared by adsorption method, the mass ratio of PCN-224(Fe) to TEPP-46 was 5:1, TEPP-46 was dissolved in DMSO, PCN-224(Fe ) was dissolved in ultrapure water, the volume ratio of ultrapure water to DMSO was 10:1, the two we...

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Abstract

The invention discloses a metal organic framework nano-carrier as well as a preparation method and application thereof. The preparation method comprises the following steps that 5,10,15,20-tetra(4-carboxyphenyl)porphyrin, zirconium chloride, ferrous chloride, eight-arm amino polyethylene glycol, benzoic acid and N,N-dimethylformamide are mixed and stirred under the water bath ultrasonic condition, and a mixed solution is obtained; microwave heating treatment is carried out on the mixed solution to obtain a reaction product; and the reaction product is centrifuged, washed and dried to obtain the metal organic framework nano-carrier. The method provided by the invention has the advantages of simple steps and high production efficiency, and the prepared metal organic framework nano-carrier is good in dispersity and stronger in capability of catalyzing hydrogen peroxide to generate hydroxyl free radicals, can be used for loading lactate oxidase and a pyruvate kinase activator, can further improve the tumor treatment efficiency, and realize the efficient inhibition on tumors.

Description

technical field [0001] The invention relates to the technical field of metal-organic framework nanomaterials, in particular to a metal-organic framework nanocarrier and its preparation method and application. Background technique [0002] Chemodynamic therapy is a treatment method that uses hydroxyl free radicals generated by tumor in situ Fenton reaction or Fenton-like reaction to kill tumor cells. It is only activated by endogenous substances and has the advantages of high regioselectivity. A novel and booming strategy for orthotopic cancer therapy. Metal-organic frameworks (MOFs) are a new class of porous materials. Due to their large surface area, porosity and adjustable chemical properties, they have shown good application prospects in catalysis, medical and other fields. [0003] The oil bath heating method is a common method for synthesizing metal-organic frameworks, but there are still some shortcomings, such as uneven heating, slow reaction, and inhomogeneous synth...

Claims

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Application Information

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IPC IPC(8): A61K47/69A61K47/60A61K31/5025A61K38/44A61K9/50A61P35/00
CPCA61K47/6949A61K47/60A61K31/5025A61K38/443A61K9/5031A61P35/00A61K2300/00
Inventor 林静郭娅茜黄鹏贺港
Owner SHENZHEN UNIV
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