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Preparation and application of mesoporous silica/tannic acid composite hydrogel hemostatic material

A technology of mesoporous silica and hemostatic material, applied in the fields of application, surgical adhesive, medical science, etc., can solve the problems of poor biocompatibility and degradability, local temperature rise, zeolite rejection, etc., to improve the adhesion performance. , improve the swelling rate, improve the effect of antibacterial properties

Inactive Publication Date: 2022-01-28
YANBIAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, zeolite hemostats generate a lot of heat during application, resulting in a sharp rise in local temperature, which may cause thermal damage to tissues
In addition, due to poor biocompatibility and degradability, zeolite remaining in the body will trigger severe rejection reactions

Method used

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  • Preparation and application of mesoporous silica/tannic acid composite hydrogel hemostatic material
  • Preparation and application of mesoporous silica/tannic acid composite hydrogel hemostatic material
  • Preparation and application of mesoporous silica/tannic acid composite hydrogel hemostatic material

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Embodiment Construction

[0024] The present invention will be described in detail below in combination with specific steps.

[0025] ① Preparation of SMS: The sol-gel method has mild reaction conditions and is the best way to prepare spherical mesoporous SiO 2 One of the commonly used methods. First, weigh 5.1g of the surfactant hexadecene-1-acetic acid with weighing paper, ultrasonically dissolve it in 350mL of deionized water, then add 382mL of isopropanol solution (99.5%) and heat it in a water bath with stirring to raise the temperature to 60°C. During this process, it will be observed that the mixture turns from milky white to transparent. Then, 2.5 mL of ammonia water (≥25%) was added to the mixed solution and stirred at 60° C. for 1 h. Finally, 27.07 g of silicon source tetraethyl orthosilicate (98%) was quickly added and stirred continuously for 15 h in a constant temperature water bath at 60° C. to end the reaction. Cool to room temperature. Repeated centrifugation and washing several tim...

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Abstract

The invention discloses preparation and application of a mesoporous silica / tannic acid composite hydrogel hemostatic material. An inorganic material mesoporous silica (SMS, SBA-15), tannic acid with adhesion performance and an organic material polyacrylamide are compounded to obtain a hydrogel hemostatic material with an antibacterial function, so that the problem of wound residue of the mesoporous silica is solved, and meanwhile, the hemostatic effect of polyacrylamide hydrogel is improved; and the swelling rate and the mechanical property of the hydrogel are also improved, and the adhesion property and the antibacterial property of the hydrogel are improved by adding the tannic acid. The mesoporous silica / tannic acid hydrogel has multiple functions of stopping bleeding, resisting bacteria and promoting healing, the preparation method is simple, convenient and rapid, and the mesoporous silica / tannic acid hydrogel has wide application prospects in multifunctional hemostatic and antibacterial materials.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to the preparation and application of a mesoporous silicon dioxide / tannic acid composite hydrogel hemostatic material with hemostatic and antibacterial functions. Background technique [0002] Uncontrolled bleeding is a major challenge in trauma first aid and surgery and a leading cause of battlefield deaths. Whether in acute trauma cases in peacetime or on the modern battlefield, rapid and effective treatment of hemorrhagic patients plays a decisive role in reducing infection rates and mortality. In military and civilian trauma centers, deaths from uncontrolled hemorrhage, especially in the early stages of hemorrhage, account for more than 30% of deaths. More than half of those deaths were due to a lack of emergency care. Due to poor pre-hospital medical conditions, massive bleeding may lead to coagulation dysfunction, infection, and multiple organ failure. Theref...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/06A61L24/00A61L24/02C08F220/56C08F222/38
CPCA61L24/06A61L24/02A61L24/0031A61L24/0015A61L24/0036C08F220/56A61L2300/232A61L2300/10A61L2300/404A61L2300/418A61L2400/04C08F222/385C08L33/26
Inventor 金明实郭建鹏曾娜朴书庆周铂凯郑通
Owner YANBIAN UNIV