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Application of Citrus reticulata 'Chachi' young fruit polymethoxylated flavonoid compound in preparation of hypolipidemic products

A technology of polymethoxyflavonoids and tangerine tea is applied in the directions of application, function of food ingredients, medical preparations containing active ingredients, etc. The effect of lowering blood lipids and increasing the content

Pending Publication Date: 2022-02-18
SUN YAT SEN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no development of tea twigs and mandarin oranges as medicine or health food for lowering blood lipids, and its medicinal value has not been fully utilized.

Method used

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  • Application of Citrus reticulata 'Chachi' young fruit polymethoxylated flavonoid compound in preparation of hypolipidemic products
  • Application of Citrus reticulata 'Chachi' young fruit polymethoxylated flavonoid compound in preparation of hypolipidemic products
  • Application of Citrus reticulata 'Chachi' young fruit polymethoxylated flavonoid compound in preparation of hypolipidemic products

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Embodiment 1 A kind of preparation method of polymethoxylated flavonoids extract of tea branches and citrus embryos

[0050] (1) Grind and sieve the dried tea twig citrus (collected from Chakeng Village, Xinhui District, Jiangmen City, Guangdong Province) to 14 meshes, and add 95% ( v / v) ethanol aqueous solution assisted by ultrasonic extraction for 3 times (power 300W, frequency 40kHz, time 30min, temperature 40°C), filtered, combined filtrates, concentrated under reduced pressure to obtain extract A1;

[0051] (2) Dissolve extract A1 in water (mass volume ratio of extract A1 to water (kg / L) 1:0.8) to obtain a suspension; add ethyl acetate (volume ratio of ethyl acetate to suspension is 3: 1) extract 3 times, combine ethyl acetate extracts, concentrate under reduced pressure to obtain extract A2;

[0052] (3) Freeze-dry the extract A2 to a constant weight to obtain the polymethoxylated flavonoid extract of Chazhi Citrus.

Embodiment 2

[0053] Embodiment 2 A kind of preparation method of polymethoxylated flavonoids extract of tea branches and citrus embryos

[0054] (1) Grind and sieve the dried tea twig citrus (collected from Chakeng Village, Xinhui District, Jiangmen City, Guangdong Province) to 14 meshes, and add 80% ( v / v) ethanol aqueous solution assisted by ultrasonic extraction 4 times (power 300W, frequency 40kHz, time 30min, temperature 40°C), filtered, combined filtrates, concentrated under reduced pressure to obtain extract A1;

[0055] (2) Dissolve extract A1 in water (mass volume ratio of extract A1 to water (kg / L) 1:0.8) to obtain a suspension; add ethyl acetate (volume ratio of ethyl acetate to suspension is 5: 1) extract twice, combine ethyl acetate extracts, concentrate under reduced pressure to obtain extract A2;

[0056] (3) Freeze-dry the extract A2 to a constant weight to obtain the polymethoxylated flavonoid extract of Chazhi Citrus.

Embodiment 3

[0057] Embodiment 3 A kind of preparation method of polymethoxylated flavonoids extract of tea branches and citrus embryos

[0058] (1) Grind and sieve the dried tea twig citrus (collected from Chakeng Village, Xinhui District, Jiangmen City, Guangdong Province) to 14 meshes, and add 70% ( v / v) ethanol aqueous solution assisted by ultrasonic extraction 5 times (power 300W, frequency 40kHz, time 30min, temperature 40°C), filtered, combined filtrates, concentrated under reduced pressure to obtain extract A1;

[0059] (2) Dissolve extract A1 in water (mass volume ratio of extract A1 to water (kg / L) 1:0.8) to obtain a suspension; add ethyl acetate (volume ratio of ethyl acetate to suspension is 4: 1) extracting 4 times, combining ethyl acetate extracts, concentrating under reduced pressure to obtain extract A2;

[0060] (3) Freeze-dry the extract A2 to a constant weight to obtain the polymethoxylated flavonoid extract of Chazhi Citrus.

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Abstract

The invention belongs to the technical field of extraction of effective components of plants, and discloses application of a Citrus reticulata 'Chachi' young fruit polymethoxylated flavonoid compound in preparation of hypolipidemic products. The preparation method of the Citrus reticulata 'Chachi' young fruit polymethoxylated flavonoid extract comprises the following steps: (1) extraction: mixing Citrus reticulata 'Chachi' young fruits with an organic solvent, conducting extracting, carrying out solid-liquid separation, taking liquid, and performing concentrating to obtain an extract A1; and (2) extraction: mixing the extract A1 with water to obtain a suspension, mixing the suspension with an organic solvent, performing extracting, and taking an organic solvent phase, namely the Citrus reticulata 'Chachi' young fruit polymethoxylated flavonoid extract. The content of the polymethoxylated flavonoid compound in the obtained Citrus reticulata 'Chachi' young fruit polymethoxylated flavonoid extract is greater than 50%; the total cholesterol content, the triglyceride content and the low-density lipoprotein cholesterol content in serum can be reduced, the high-density lipoprotein cholesterol content can be slightly increased, an obvious hypolipidemic effect is achieved, and the compound can be used for preparing hypolipidemic products.

Description

technical field [0001] The invention belongs to the technical field of extraction and application of plant effective components, and in particular relates to the application of polymethoxylated flavonoids of tea branches and mandarin oranges in the preparation of blood lipid-lowering products. Background technique [0002] Dyslipidemia, often called hyperlipidemia, is a metabolic disease caused by various causes of abnormal changes in the concentration of various lipids in plasma at the pathological level. The World Health Organization survey statistics show that hyperlipidemia It is one of the main risk factors for cardiovascular disease, which is currently the number one cause of death worldwide. Relevant disease monitoring data show that the number of disabled and dead people due to hyperlipidemia-related diabetes, stroke, cerebral infarction, hemiplegia, and myocardial infarction is increasing year by year. At present, the drugs for treating hyperlipidemia mainly includ...

Claims

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Application Information

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IPC IPC(8): A61K36/752A61K31/352A61P3/06A23L33/105A61K131/00
CPCA61K36/752A61K31/352A61P3/06A23L33/105A23V2002/00A23V2200/3262A23V2250/21162
Inventor 杨得坡张荣菲梅振英赵志敏刘鄂湖
Owner SUN YAT SEN UNIV