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Medical adhesive with hemostasis function and use method thereof

A technology of adhesives and functions, applied in the field of medical adhesives with hemostatic function, can solve the problems of medical adhesives with single function, no procoagulant function, complicated operation, etc., achieve good biological safety, reduce operation time, and simple operation

Inactive Publication Date: 2022-02-18
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, sutures and staplers are mostly used for wound closure of human tissue wounds. This wound closure method is complicated to operate, and the secondary injury during the operation also brings greater pain to the patient, and at the same time causes varying degrees of damage to the tissue. Commercialized medical adhesives that are substitutes for sutures and staplers have a single function and do not have the function of promoting blood coagulation. The continuous bleeding of wounds has an adverse effect on the adhesion of medical adhesives

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] In the first step, according to R value = 1.2, OH value = 2.4, dissolve 4.34g of lysine diisocyanate (0.019mol) in 11mL of tetrahydrofuran, and add it into a round bottom flask under stirring; Diol (Mn=200, 0.008mol) was dissolved in 3.2ml of tetrahydrofuran, and slowly added to a round bottom flask to react with lysine diisocyanate for 3 hours at a reaction temperature of 20°C to obtain an isocyanate-terminated intermediate.

[0019] In the second step, according to R value = 1.2, OH value = 2.4, dissolve 0.491g of glycerol (0.005mol) in 20ml of tetrahydrofuran, slowly add to the intermediate in the first step, and react at 20°C for 3h, A solvent-containing polyurethane adhesive for medical use is obtained.

[0020] In the third step, the product obtained in the second step is transferred to a rotary evaporator, and rotated at 50°C for 1 hour to obtain a polyurethane prepolymer of a medical adhesive with a hemostatic function, which is stored in a dry place after addin...

Embodiment 2

[0027] In the first step, according to R value=1.8, OH value=2.9, 47.24g lysine diisocyanate (0.209mol) was dissolved in 50mL tetrahydrofuran, and it was added in a round bottom flask; 8g polyethylene glycol (Mn =1000, 0.008mol) was dissolved in 40ml of tetrahydrofuran, and slowly added to a round bottom flask to react with lysine diisocyanate for 12 hours at a reaction temperature of 60°C to obtain an isocyanate-terminated intermediate.

[0028] In the second step, according to R value = 1.8, OH value = 2.9, dissolve 6.63 g of glycerol (0.072 mol) in 20 ml of tetrahydrofuran, slowly add it to the intermediate in the first step, and react at 60 ° C for 22 h, A solvent-containing polyurethane adhesive for medical use is obtained.

[0029] In the third step, the product obtained in the second step is transferred to a rotary evaporator, and rotated at 50°C for 1 hour to obtain a polyurethane prepolymer of a medical adhesive with a hemostatic function, which is stored in a dry pla...

Embodiment 3

[0036]In the first step, according to R value=1.7, OH value=2.5, 7.56g of isophorone diisocyanate (0.034mol) was dissolved in 18mL of tetrahydrofuran, and it was added into a round bottom flask under stirring; Ethylene glycol (Mn=400, 0.008mol) was dissolved in 4.8ml of tetrahydrofuran, and slowly added to a round bottom flask to react with lysine diisocyanate for 8 hours at a reaction temperature of 30°C to obtain an isocyanate group-terminated intermediate.

[0037] In the second step, according to R value = 1.7, OH value = 2.5, dissolve 0.36 g of pentaerythritol (0.0027 mol) in 20 ml of tetrahydrofuran, slowly add it to the intermediate in the first step, and react at 30 ° C for 5 h to obtain Solvent based medical polyurethane adhesive.

[0038] In the third step, the product obtained in the second step is transferred to a rotary evaporator, and rotated at 40°C for 1 hour to obtain a polyurethane prepolymer of a medical adhesive with a hemostatic function, which is stored i...

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Abstract

The invention discloses a medical adhesive with a hemostatic function and a use method thereof. The medical adhesive comprises a component A and a component B, the component A is a polyurethane prepolymer based on polyethylene glycol and micromolecular polyol, and the component B is a modified secondary amine curing agent containing clay. The component A is prepared by the following steps of: reacting polyethylene glycol PEG with diisocyanate DI to obtain an intermediate, and adding a micromolecular polyol chain extender to obtain a polyurethane prepolymer. The component B is obtained by the following steps of: reacting diprimary amine with an alpha, beta-unsaturated carbonyl compound according to a functional group molar ratio of -NH2: -C = C being 1: 1 under a transition metal catalysis condition, obtaining a curing agent precursor through extraction and rotary evaporation after the reaction is completed, and mixing the curing agent precursor with clay according to a mass ratio of (0.02-0.2): 1 to obtain the component B. The medical adhesive prepared in the invention has the advantages of fast curing, good biocompatibility, high adhesion strength and good procoagulant effect, and is suitable for fast plugging and repairing of wounds under bleeding conditions.

Description

technical field [0001] The invention relates to the technical fields of biomedical materials, tissue engineering and regenerative medicine, in particular to a medical adhesive with hemostatic function and its application method. Background technique [0002] At present, sutures and staplers are mostly used for wound closure of human tissue wounds. This wound closure method is complicated to operate, and the secondary injury during the operation also brings greater pain to the patient, and at the same time causes varying degrees of damage to the tissue. The commercialized medical adhesives that are substitutes for sutures and staplers have a single function and do not have the function of promoting blood coagulation. The continuous bleeding of the wound has an adverse effect on the adhesion of the medical adhesives. Contents of the invention [0003] The purpose of the present invention is to overcome the shortcomings and deficiencies of the prior art, and propose a medical...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/04A61L24/02A61L24/00C08G18/32C08G18/66C08G18/48
CPCA61L24/0015A61L24/02A61L24/046C08G18/3206C08G18/3228C08G18/6685C08G18/4833A61L2400/06A61L2300/418C08L71/02C08L75/04
Inventor 施雪涛张照国宣承楷
Owner SOUTH CHINA UNIV OF TECH