Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A technology of mesoporous silica and nano-microspheres, applied in botany equipment and methods, biocides, fungicides, etc., can solve the problems of poor target adsorption permeability, poor solubility, drug loss, etc., and achieve good biocompatibility and degradability, low viscosity, and improved stability
Active Publication Date: 2022-03-01
WUHAN MARINE ELECTRIC PROPULSION RES INST CHINA SHIPBUILDING IND CORP NO 712 INST
View PDF5 Cites 0 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
[0003] Uniconazolepowder is configured as pesticide spraying. Because of its extremely poorsolubility in water, and the powder particles are relatively coarse, the adsorption and permeability of the target is poor, which will easily cause a large amount of drug loss, low drug efficacy, and environmental pollution. In line with the concept of green pesticides
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
[0035] (CTAB), 13.5g isobutanol and 2g ethylene glycol, 45°C, 400 r / min, keep stirring for 30min, under stirring, add 17.5g pure water at a drop rate of 1.0 mL / min, and keep stirring for 15min to obtain ene Put the microemulsion of clobutrazol in the cold, let it stand to observe the clarification of the microemulsion, and stand it at -5°C (refrigerated), room temperature and 54°C (hot storage) for 48 hours to observe the change of the microemulsion.
[0038] Ammoniumchloride (CTAB), 13.5g of isobutanol and 2g of ethylene glycol, 45°C, 400 r / min, continue to stir for 30min, under stirring, add 17.5g of pure water at a drop rate of 1.0 mL / min, and continue to stir for 15min to prepare The uniconazole microemulsion was obtained, let it cool, and observed the clarification of the microemulsion, and then stood it at -5°C (refrigerated), room temperature and 54°C (hot storage) for 48 hours to observe the change of the microemulsion.
[0041] (CTAB), 13.5g isobutanol and 2g ethylene glycol, 45°C, 400 r / min, keep stirring for 30min, under stirring, add 17.5g pure water at a drop rate of 1.0 mL / min, and keep stirring for 15min to obtain ene Put the microemulsion of clobutrazol in the cold, let it stand to observe the clarification of the microemulsion, and stand it at -5°C (refrigerated), room temperature and 54°C (hot storage) for 48 hours to observe the change of the microemulsion.
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
PUM
Property
Measurement
Unit
pore size
aaaaa
aaaaa
particle diameter
aaaaa
aaaaa
thickness
aaaaa
aaaaa
Login to View More
Abstract
The invention discloses a preparation method of a mesoporous silica nano double-layer microspherecontrolled release agent, which comprises the following steps: preparing a stable 12% uniconazolemicroemulsion by a microemulsion method, and preparing drug-loaded mesoporous silica nano microspheres by a microemulsion-template method. Finally, the outer layer is coated with poly-gamma-glutamic acid with low average molecular weight under the electrostatic bridging effect of polyethyleneimine, the high-dispersity MSNs-Uniconazol-coated PEI-coated gamma-PGA nano double-layer microspherecontrolled release agent with the particle size being about 86 nm and the shell thickness being about 8 nm is prepared, and the MSNs-Uniconazol-coated PEI-coated gamma-PGA nano double-layer microspherecontrolled release agent comprises 84.8% of mesoporous silica nanoparticles, 12.7% of uniconazole, 1.5% of polyethyleneimine and 1.0% of poly-gamma-glutamic acid. The gamma-PGA is used for wrapping the MSNs-Uniconazole, so that not only are the biocompatibility and the degradability good, but also the problems that the medicine is released in advance and the lasting period is short are solved.
Description
technical field [0001] The invention belongs to the technical field of new nano-controlled release materials, and in particular relates to a preparation method of a mesoporous silicon dioxide nanometer double-layer microsphere controlled-release agent. Background technique [0002] Due to its special pore structure and large specific surface area, mesoporous silica material has great adsorption capacity and high activity, low toxicity and good biocompatibility to reduce the impact on the environment, making it widely used in It has a wide range of applications in drug sustained release and noble metal nanocatalyst loading. [0003] Uniconazolepowder is configured as pesticide spraying. Because of its extremely poorsolubility in water, and the powder particles are relatively coarse, the adsorption and permeability of the target is poor, which will easily cause a large amount of drug loss, low drug efficacy, and environmental pollution. In line with the concept of green pes...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to View More