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Preparation method of mesoporous silica nano double-layer microsphere controlled release agent

A technology of mesoporous silica and nano-microspheres, applied in botany equipment and methods, biocides, fungicides, etc., can solve the problems of poor target adsorption permeability, poor solubility, drug loss, etc., and achieve good biocompatibility and degradability, low viscosity, and improved stability

Active Publication Date: 2022-03-01
WUHAN MARINE ELECTRIC PROPULSION RES INST CHINA SHIPBUILDING IND CORP NO 712 INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Uniconazole powder is configured as pesticide spraying. Because of its extremely poor solubility in water, and the powder particles are relatively coarse, the adsorption and permeability of the target is poor, which will easily cause a large amount of drug loss, low drug efficacy, and environmental pollution. In line with the concept of green pesticides

Method used

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  • Preparation method of mesoporous silica nano double-layer microsphere controlled release agent
  • Preparation method of mesoporous silica nano double-layer microsphere controlled release agent
  • Preparation method of mesoporous silica nano double-layer microsphere controlled release agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Weigh 12g of uniconazole, add 35g of ethyl acetate and 20g of cetyltrimethylammonium bromide successively

[0035] (CTAB), 13.5g isobutanol and 2g ethylene glycol, 45°C, 400 r / min, keep stirring for 30min, under stirring, add 17.5g pure water at a drop rate of 1.0 mL / min, and keep stirring for 15min to obtain ene Put the microemulsion of clobutrazol in the cold, let it stand to observe the clarification of the microemulsion, and stand it at -5°C (refrigerated), room temperature and 54°C (hot storage) for 48 hours to observe the change of the microemulsion.

Embodiment 2

[0037] Weigh 12g uniconazole, add 35g N,N -Dimethylformamide, 20g cetyltrimethyl bromide

[0038] Ammonium chloride (CTAB), 13.5g of isobutanol and 2g of ethylene glycol, 45°C, 400 r / min, continue to stir for 30min, under stirring, add 17.5g of pure water at a drop rate of 1.0 mL / min, and continue to stir for 15min to prepare The uniconazole microemulsion was obtained, let it cool, and observed the clarification of the microemulsion, and then stood it at -5°C (refrigerated), room temperature and 54°C (hot storage) for 48 hours to observe the change of the microemulsion.

Embodiment 3

[0040] Weigh 12g uniconazole, add 35g cyclohexanone, 20g cetyltrimethylammonium bromide successively

[0041] (CTAB), 13.5g isobutanol and 2g ethylene glycol, 45°C, 400 r / min, keep stirring for 30min, under stirring, add 17.5g pure water at a drop rate of 1.0 mL / min, and keep stirring for 15min to obtain ene Put the microemulsion of clobutrazol in the cold, let it stand to observe the clarification of the microemulsion, and stand it at -5°C (refrigerated), room temperature and 54°C (hot storage) for 48 hours to observe the change of the microemulsion.

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Abstract

The invention discloses a preparation method of a mesoporous silica nano double-layer microsphere controlled release agent, which comprises the following steps: preparing a stable 12% uniconazole microemulsion by a microemulsion method, and preparing drug-loaded mesoporous silica nano microspheres by a microemulsion-template method. Finally, the outer layer is coated with poly-gamma-glutamic acid with low average molecular weight under the electrostatic bridging effect of polyethyleneimine, the high-dispersity MSNs-Uniconazol-coated PEI-coated gamma-PGA nano double-layer microsphere controlled release agent with the particle size being about 86 nm and the shell thickness being about 8 nm is prepared, and the MSNs-Uniconazol-coated PEI-coated gamma-PGA nano double-layer microsphere controlled release agent comprises 84.8% of mesoporous silica nanoparticles, 12.7% of uniconazole, 1.5% of polyethyleneimine and 1.0% of poly-gamma-glutamic acid. The gamma-PGA is used for wrapping the MSNs-Uniconazole, so that not only are the biocompatibility and the degradability good, but also the problems that the medicine is released in advance and the lasting period is short are solved.

Description

technical field [0001] The invention belongs to the technical field of new nano-controlled release materials, and in particular relates to a preparation method of a mesoporous silicon dioxide nanometer double-layer microsphere controlled-release agent. Background technique [0002] Due to its special pore structure and large specific surface area, mesoporous silica material has great adsorption capacity and high activity, low toxicity and good biocompatibility to reduce the impact on the environment, making it widely used in It has a wide range of applications in drug sustained release and noble metal nanocatalyst loading. [0003] Uniconazole powder is configured as pesticide spraying. Because of its extremely poor solubility in water, and the powder particles are relatively coarse, the adsorption and permeability of the target is poor, which will easily cause a large amount of drug loss, low drug efficacy, and environmental pollution. In line with the concept of green pes...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N25/08A01N25/26A01N25/04A01N43/653A01P3/00
CPCA01N25/08A01N25/26A01N25/04A01N43/653Y02A50/30
Inventor 游立张轶丁刚强李玉龙刘倩倩
Owner WUHAN MARINE ELECTRIC PROPULSION RES INST CHINA SHIPBUILDING IND CORP NO 712 INST
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