Instrument and method for mobilizing intra-articular stem cells during operation

A stem cell and intra-articular technology, applied in passive exercise equipment, surgery, inoculation and ovulation diagnosis, etc., can solve the problems of complex operation, cell contamination, stem cell tumorigenesis, etc., and achieve the effects of cost reduction, convenient injection, and convenient operation.

Active Publication Date: 2022-03-11
PEKING UNIV THIRD HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this operation has obvious disadvantages: 1. The operation is complicated, resulting in expensive stem cell therapy; 2. In vitro culture can affect the differentiation potential of stem cells; 3. There is a risk of cell contamination in in vitro culture; 4. The presence of stem cells expanded in vitro Tumor risk
However, in the current arthroscopic operation, because it is necessary to ensure the clarity of the entire surgical field, it is necessary to use saline lavage fluid to clean the joint cavity during the whole process, which seriously affects the original number of stem cells in the joint fluid, thereby affecting the stability of the postoperative joint. state and tissue healing ability
[0004] The current stem cell transplantation treatment basically requires a second operation, that is, first obtain tissue rich in stem cells, separate, extract, and amplify stem cells in vitro, and finally transplant the amplified stem cells in a second operation. This operation is complicated and causes Stem cell therapy is expensive; in vitro culture can affect the differentiation potential of stem cells; there is a risk of cell contamination in in vitro culture; transplantation of in vitro expanded stem cells has a tumorigenic risk

Method used

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  • Instrument and method for mobilizing intra-articular stem cells during operation
  • Instrument and method for mobilizing intra-articular stem cells during operation
  • Instrument and method for mobilizing intra-articular stem cells during operation

Examples

Experimental program
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Effect test

Embodiment 1

[0037] see Figure 1-Figure 9 , the present invention provides a device and method for mobilizing stem cells in a joint during operation, comprising a host 1, a brush head 2, and a charging base 3, the brush head 2 is connected to the top of the host 1, the host 1 and the brush head 2 are detachably connected, The host 1 can be connected to the charging base 3 for charging, and the operation is convenient.

[0038] The host 1 includes a sound wave motor 8, an output shaft 9 and a plurality of indicator lights. The sonic motor 8 is used to generate sonic vibrations of one or more frequencies. The sound waves are related to the frequency of motion of the sound wave motor 8 . In some embodiments, the sound waves are audible sound waves with a frequency of 20 Hz-20 kHz. In some embodiments, the sound wave is an ultrasonic wave with a frequency of 20 kHz to 1 GHz. The sound wave motor 8 is fixedly installed inside the host 1 and connected to the output shaft 9 . After receivin...

Embodiment 2

[0050] Taking the treatment of knee articular cartilage injury as an example, the specific implementation plan is as follows: After the arthroscopy enters the knee joint cavity, the structure of the suprapatellar pouch, the medial and lateral recesses of the knee joint, the medial and lateral meniscus, the cruciate ligament of the knee joint, cartilage, etc. Tissue structure, to clarify the degree and scope of cartilage damage, routine cleaning and freshening of the damaged cartilage area, and then use pyramid-shaped micro-fracture instruments to make micro-fractures of the subchondral bone in the cartilage defect area, forming multiple Connecting and bleeding microfracture holes. Finally, the device for mobilizing intra-articular stem cells during the operation is used to stimulate the synovial tissue in the joint cavity, including the synovial tissue of the suprapatellar bursa, inner and outer recesses of the knee joint. After the synovial tissue is stimulated by vibration, i...

Embodiment 3

[0052] Taking the treatment of knee articular cartilage injury as an example, the specific implementation plan is as follows: After the arthroscopy enters the knee joint cavity, the structure of the suprapatellar pouch, the medial and lateral recesses of the knee joint, the medial and lateral meniscus, the cruciate ligament of the knee joint, cartilage, etc. Tissue structure, to clarify the degree and scope of cartilage damage, routine cleaning and freshening of the damaged cartilage area, and then use pyramid-shaped micro-fracture instruments to make micro-fractures of the subchondral bone in the cartilage defect area, forming multiple Connecting and bleeding microfracture holes. Finally, a device that mobilizes intra-articular stem cells during the operation is used to stimulate the adipose tissue in the infrapatellar fat pad in the joint cavity. After the adipose tissue is stimulated by vibration, more adipose-derived stem cells can be released, thereby promoting the repair ...

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Abstract

The invention relates to the technical field of medical equipment, in particular to an instrument and method for mobilizing stem cells in joints in an operation, the instrument comprises a main machine, a brush head and a charging base, the main machine is detachably connected with the brush head, and the main machine comprises a sound wave motor used for generating sound wave vibration; the output shaft is respectively connected with the sound wave motor and the brush head and is used for outputting the sound wave vibration to the brush head; the sound wave motor is used for driving the brush head to vibrate, so that synovial membranes and adipose tissues in joints can be mobilized to release more stem cells; operation is convenient, and operation can be carried out simultaneously in an operation; accompanying operation can be carried out in the operation, the cost is obviously reduced, and extra treatment cost is basically not needed; the stem cells do not need to be cultured in vitro, the whole process is carried out in vivo, and the proliferation and differentiation capacity of the stem cells cannot be influenced; stem cells do not need to be cultured in vitro, and cell pollution or tumorigenesis risks do not exist.

Description

technical field [0001] The invention relates to the technical field of medical equipment, in particular to a device and method for mobilizing intra-articular stem cells during surgery. Background technique [0002] The stability of the tissue structure in the joint is crucial to maintaining the function of the entire joint. For example, the meniscus of the knee joint plays the role of absorbing shock, cushioning decompression, and maintaining joint stability; the anterior and posterior cruciate ligaments are important for maintaining the stability of the entire joint very important. Once the tissue structure in the joint is damaged, it can cause secondary joint degeneration, such as cartilage wear and tear, synovial inflammation, etc., and eventually even develop into osteoarthritis. Cell transplantation therapy can promote the repair of intra-articular tissue damage, especially mesenchymal stem cells, which have the potential of self-renewal and multi-directional different...

Claims

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Application Information

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IPC IPC(8): A61B90/00A61B10/02A61H1/00
CPCA61B90/08A61B10/02A61H1/00A61B2010/0216
Inventor 闫文强敖英芳程锦胡晓青龚熹
Owner PEKING UNIV THIRD HOSPITAL
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