Selenium-doped hydroxyapatite nano-enhanced collagen GBR membrane and preparation method thereof
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A selenium hydroxyapatite and nano-enhanced technology, applied in the field of medicine, can solve the problems of poor mechanical properties, unfavorable long-term regeneration and repair of bone defects, high degradation rate, etc., and achieve the effect of improving mechanical properties
Pending Publication Date: 2022-03-15
JINAN UNIVERSITY
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However, in clinical applications, Bio-Gide biofilms have shortcomings such as high degradation rate, poor mechanical properties, and poor antibacterial properties, which are not conducive to the long-term regeneration and repair of bone defects.
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Embodiment 1
[0034] Embodiment 1, the present invention provides a method for preparing a selenium-doped hydroxyapatite nano-reinforced collagen GBR membrane, comprising steps:
[0035] (1) Prepare selenium-doped hydroxyapatite (Se-HAP), and Se / (Se+P) is synthesized into a Se-HAP nanostructure through a solvothermal method; the Se / (Se / ( Se+P) Se-doped Se-HAP nanowires, or nanoneedles, or nanosheet structures were synthesized by a solvothermal method.
[0036] Further, step (1) specifically includes, dissolving 9-10g NaOH in 140-150mL deionized water, stirring mechanically in an ice-water bath and adding 120-140mL deionized water, 50-60mL methanol and 100-110mL oleic acid, and dissolving 2.5 -3.5g CaCl 2 The aqueous solution was added dropwise and mixed to obtain a mixed solution. After stirring, 180-190mL of NaH 2 PO 4 2H 2 O (8-9.5g) and Na 2 SeO 3 (0.02-0.035g) were added dropwise into the mixed solution, the resulting mixture was transferred to an autoclave, sealed and heated at 1...
Embodiment 2
[0038] Embodiment 2, the present invention provides a method for preparing a selenium-doped hydroxyapatite nano-reinforced collagen GBR membrane, including:
[0039] Step (1), preparing selenium-doped hydroxyapatite (Se-HAP), and using Se / (Se+P) to synthesize Se-HAP nanostructures by solvothermal method.
[0040] The molar fractions of the Se / (Se+P) are respectively 0%, 0.05%, 0.1%, 0.2% and 0.3%, which are named HAP, 0.5Se-HAP, 1Se-HAP, 2Se-HAP and 3Se-HAP respectively. HAP, HAP nanowires and Se-HAP nanostructures with different Se-doped amounts were synthesized by solvothermal method. In this way, comparative experiments can be done to screen out the Se-HAP nanowires with the best selenium content.
[0041] For example, the synthesis process of Se-HAP nanowires with a mole fraction of 0.3% is as follows. Dissolve 10.05g NaOH in 150mL deionized water, add 135mL deionized water, 60mL methanol and 105mL oleic acid with mechanical stirring in an ice-water bath, mix 120mL CaCl ...
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Abstract
The invention discloses a selenium-doped hydroxyapatite nano-enhanced collagen GBR membrane and a preparation method thereof, and the preparation method comprises the following steps: (1) preparing selenium-doped hydroxyapatite (Se-HAP), and synthesizing Se/(Se + P) into a Se-HAP nano-structure through a solvothermal method; (2) adding animal skin collagen into an acetic acid solution, stirring to prepare a collagen solution, mechanically stirring until the collagen is completely dissolved, and uniformly dispersing the collagen in an interval low-temperature ultrasonic manner; the preparation method comprises the following steps: preparing a collagen solution, adding Se-HAP nanowire powder into an aqueous solution, fully stirring to prepare Se-HAP slurry, uniformly mixing the collagen solution and the Se-HAP slurry to obtain a collagen/Se-HAP mixed solution, performing ultrasonic treatment on the collagen/Se-HAP mixed solution, concentrating the collagen solution into a collagen solution, performing centrifugal treatment on the collagen solution, and cooling the collagen solution to 0 DEG C or below on a freezing device to obtain the collagen/Se-HAP nanowire composite material. The selenium-doped hydroxyapatite nanowire enhanced collagen GBR membrane can be applied to medical rehabilitation for guiding bone regeneration, and has excellent properties of antibacterial property and promoting osteogenic differentiation and regeneration.
Description
technical field [0001] The patent relates to the field of medical technology, in particular to a selenium-doped hydroxyapatite nano-reinforced collagen GBR membrane and a preparation method thereof. Background technique [0002] The repair of craniofacial and maxillofacial bone defects is still a challenge in the treatment of plastic surgery and oral and maxillofacial surgery. It usually needs to be repaired with bone powder and guided tissue regeneration membrane, but the repair of large defects is still a difficult point in clinical practice. Guided bone regeneration (GBR) technology: Based on the properties of the barrier membrane covering the bone defect area, it prevents the invasion of fibroblasts from the surrounding soft tissue, allowing the osteoblasts on the bone surface to have enough time to adhere, proliferate, and form osteogenesis differentiation, and ultimately achieve the purpose of bone tissue regeneration and repair. In complex bone defect areas such as a...
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