Unlock instant, AI-driven research and patent intelligence for your innovation.

Composite bone cement material and preparation method thereof

A kind of bone cement, liquid phase technology, applied in prosthesis, tissue regeneration, medical science and other directions, can solve the problems of surrounding tissue necrosis, shortcomings can not be ignored, lack of biological activity, etc., to improve biological activity, good operability, biological good compatibility

Active Publication Date: 2022-03-22
UNIV OF SCI & TECH BEIJING +1
View PDF9 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, with the clinical application and follow-up of PMMA bone cement, many shortcomings have also been found, such as non-degradable, lack of biological activity, high temperature during polymerization, easy to cause necrosis of surrounding tissues, etc.
Although there are already many PMMA bone cement products on the market, its shortcomings cannot be ignored.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Composite bone cement material and preparation method thereof
  • Composite bone cement material and preparation method thereof
  • Composite bone cement material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] 1. Preparation method of composite bone cement material

[0025] 1) Preparation of powder phase:

[0026] Biphasic calcium phosphate, its specific preparation method is: (1) two kinds of powder ingredients (the mass ratio of hydroxyapatite in biphasic calcium phosphate is 30%, the mass ratio of β-tricalcium phosphate in biphasic calcium phosphate ratio of 70%.) and agate balls according to the ball-to-material ratio of 1:2 dry mixing, ball milling for 8 hours, and passing through a 200-mesh sieve to obtain biphasic calcium phosphate powder, wherein the two powders are hydroxyl phosphorus with a molecular weight of 500 Limestone, beta-tricalcium phosphate with a molecular weight of 310.

[0027] The polymethyl methacrylate microspheres have a molecular weight of ~110,000 and a particle size of 80um.

[0028] Human hair is washed, degreased, ground, and passed through a 200-mesh sieve to obtain human hair keratin powder.

[0029] Weigh the powder phase according to the...

Embodiment 2 to 5

[0041] The sample preparation of each embodiment is with embodiment 1 process, but concrete composition is as follows table 2:

[0042] Table 2

[0043]

[0044] The prepared bone cement samples were sterilized, weighed and put into centrifuge tubes, and culture solution was added at a ratio of 0.2g:1 ml, and soaked at 37°C for 24 hours to obtain the extract. Using the MTT method: Digest the subcultured mesenchymal stem cells MSCg with trypsin, inoculate the obtained cell suspension into a 96-well plate, and add 100 μl (5×10 3 cells / ml) of the cell suspension, and the samples of each example were inoculated into 5 wells. After incubating for 6-24 hours, let the cells adhere completely, aspirate the supernatant with a pipette gun, and then add 100ul of extraction solution. Cells were cultured for 1, 3, and 5 days in the culture medium containing the extract, and then 20ul of MTT solution was added and placed in an incubator (37°C, 5% CO 2 ) incubate for 4 hours, use a pip...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Particle sizeaaaaaaaaaa
Particle sizeaaaaaaaaaa
Login to View More

Abstract

Raw materials of the composite bone cement comprise a powder phase and a liquid phase, and the powder phase comprises the following components in percentage by mass: 30%-90% of polymethyl methacrylate (PMMA) microspheres, 10%-50% of biphase calcium phosphate (BCP), 0.5%-5% of human hair keratin, 0.8%-3% of benzoyl peroxide (BPO) and 4%-14% of zirconium dioxide (ZrO2); the liquid phase comprises the following components in percentage by mass: 97%-99.5% of methyl methacrylate (MMA), 0.5%-3% of N, N-dimethyl p-toluidine (DMPT) and 0.05%-1% of hydroquinone; fully mixing and uniformly stirring the powder phase and the liquid phase, and curing in a mold to obtain the composite bone cement. Under the condition that the PMMA bone cement is easy to inject and excellent in mechanical property, after the BCP and the human hair keratin are added, the polymerization temperature can be reduced, the operation time can be prolonged, and the composite bone cement material with good biological activity and biocompatibility can be obtained.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a composite bone cement material and a preparation method thereof. Background technique [0002] Due to the aggravation of population aging, a large number of bone defects or injuries are caused by osteoporosis, bone tumors, osteomyelitis, trauma and other diseases every year. Among them, patients suffering from osteoporosis and arthritis account for more than half of all chronic patients, which seriously affect the quality of life of the elderly. At present, the clinical treatment of bone defects mainly includes autologous bone grafting, allogeneic bone grafting and artificial bone repair. Although autologous bone grafting is highly osteoinductive, additional incisions are required for bone harvesting, which increases trauma and may cause long-term pain in the bone harvesting area after surgery. Less, can not meet a large number of bone grafts. Although allograft ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61L27/16A61L27/50A61L27/22A61L27/12A61L27/54
CPCA61L27/16A61L27/50A61L27/227A61L27/12A61L27/54A61L2430/02A61L2300/112A61L2300/412C08L33/12C08L89/00
Inventor 牛亚迪李志刚牛康民危岩王海峰姜乃生伍英李宏福唐雯阮志
Owner UNIV OF SCI & TECH BEIJING