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Preparation method of drug-loaded bone repair stent for promoting ordered vascularization through 3D printing and product and application of drug-loaded bone repair stent

A 3D printing and vascularization technology, applied in medical science, prosthesis, additive processing, etc., can solve problems such as poor function of vascular network, disordered vascular network, lack of blood supply, etc., to promote bone tissue healing and mechanical properties Good, good bone conduction effect

Active Publication Date: 2022-04-01
SHANGHAI NAT ENG RES CENT FORNANOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003]Internal vascularization of bone repair materials is a major challenge in clinical bone repair [Cassell, Br. J.Plast. Surg., 2002], lack of blood supply, new Bone growth cannot obtain a sustainable material source, and bone fusion between the material and the surrounding bone tissue cannot occur, so that the bone repair material cannot be replaced by new "living bone"
In the current research, the generation of vascular network is usually constructed based on tissue engineering methods such as growth factor loading and endothelial cell co-culture, but the new vascular network often has defects such as disorder and distortion, which makes it easy to form thrombus, hemangioma and abnormality. Blood vessels, etc., angiogenesis is uncontrollable, and new blood vessels cannot be fully perfused and effectively integrated with host blood vessels, resulting in extremely poor function of reconstructing the vascular network [White, Tissue Eng Part A., 2014]

Method used

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  • Preparation method of drug-loaded bone repair stent for promoting ordered vascularization through 3D printing and product and application of drug-loaded bone repair stent
  • Preparation method of drug-loaded bone repair stent for promoting ordered vascularization through 3D printing and product and application of drug-loaded bone repair stent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A 3D printing drug-loaded bone repair scaffold that promotes orderly vascularization, prepared according to the following steps:

[0033] (1) Preparation of α-TCP:

[0034] Mix calcium hydrogen phosphate and calcium carbonate at a molar ratio of 2:1, use an appropriate amount of absolute ethanol as the medium for wet ball milling, rotate at 400 rpm, and mill for 4 hours. The mass ratio of ball milling beads to powder is 2:1, and the raw material mixture is removed by rotary evaporation. Ethanol, dried in an oven at 60°C for 24h; after drying, use a muffle furnace to calcinate at 1400°C for 2h, take it out, and cool it rapidly under a blast environment, and then, use absolute ethanol as the medium, and wet ball mill at 450rpm , milled for 6 hours with a zirconia ball milling jar, the mass ratio of milling beads to powder was 4:1, and the obtained powder suspension was dried in an oven at 80°C to obtain α-TCP powder with uniform particle size;

[0035] (2) Weigh 5 g of g...

Embodiment 2

[0039] Others are the same as in Example 1, except that in step (3) VEGF is replaced by SVVYGLR polypeptide, and a drug-loaded bone repair scaffold promoting orderly vascularization is prepared.

Embodiment 3

[0041] Others are the same as in Example 1, except that in step (3), VEGF is replaced by platelet-derived growth factor PDGF, and a drug-loaded bone repair scaffold promoting orderly vascularization is prepared.

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Abstract

The invention relates to a preparation method of a drug-loaded bone repair stent for promoting ordered vascularization through 3D printing as well as a product and application of the drug-loaded bone repair stent for promoting ordered vascularization through 3D printing, two kinds of 3D printing ink are prepared, one kind of 3D printing ink is self-curing calcium phosphate bone cement ink with alpha-TCP as a main body; and the other medicine-carrying ink is prepared by adding a vascularization promoting growth factor into the ink. A double-nozzle 3D printing mode is adopted, the two kinds of ink are printed layer by layer according to model design, the path of the medicine-carrying ink is kept consistent in the radial direction, after printing is completed, standing is conducted for 24 h at the room temperature, the calcium phosphate bone cement is naturally solidified, and the medicine-carrying bone repair support promoting ordered vascularization is obtained. The calcium phosphate bone repair scaffold is used as a carrier, has good osteoconductivity, can promote bone tissue healing, has good mechanical properties, and has a certain bearing capacity.

Description

technical field [0001] The invention relates to a method in the technical field of biomedical materials, in particular to a method for preparing a 3D printing drug-loaded bone repair scaffold that promotes orderly vascularization, and its product and application, and a 3D printing patterned design that promotes biomedical Method for Sequentially Vascularized Drug-Loaded Scaffolds for Bone Repair. Background technique [0002] Bone tissue engineering provides a new idea for clinically solving large-area bone defects, and artificial bone repair materials are expected to replace natural bone as a new repair filling material. Among them, calcium phosphate-based bone repair materials have received extensive research and attention. The chemical composition of hydroxyapatite or calcium-deficient hydroxyapatite is similar to the inorganic composition of natural bone, and Ca and P elements are released through the biodegradation of the material itself. , can promote the biomineraliz...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/54A61L27/12A61L27/22B33Y70/10B33Y80/00
CPCA61L27/12A61L27/22A61L27/42A61L27/50A61L27/54B33Y70/10B33Y80/00
Inventor 崔大祥杨迪诚朱君余将明
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
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