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Preparation method and application of acellular porcine dermal matrix thermosensitive antibacterial conductive scaffold

A technology of acellular porcine dermis and conductive scaffold is applied in the field of preparation of acellular porcine dermal matrix thermosensitive antibacterial conductive scaffold, which can solve the problems of large skin defect and high recurrence risk of surgical operation, and achieves the promotion of cell growth and wound promotion. The effect of tissue healing

Active Publication Date: 2022-07-22
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As the primary treatment for this type of skin disease, surgery has a high risk of recurrence and large skin defects

Method used

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  • Preparation method and application of acellular porcine dermal matrix thermosensitive antibacterial conductive scaffold
  • Preparation method and application of acellular porcine dermal matrix thermosensitive antibacterial conductive scaffold
  • Preparation method and application of acellular porcine dermal matrix thermosensitive antibacterial conductive scaffold

Examples

Experimental program
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Effect test

Embodiment 1

[0053] 1) Preparation of polystyrene emulsion: Weigh 1.0g of polyvinylpyrrolidone in 0.5L of ultrapure water, transfer to the reactor after the polyvinylpyrrolidone is completely dissolved, add 50g of styrene, purge with nitrogen for 10min, and heat to 50 ℃ and constant temperature stirring for 10min; adding 5.0mL of 2,2'-azobisisobutyramidine hydrochloride, nitrogen protection for 1h to obtain a polystyrene emulsion.

[0054] 2) Preparation of hollow silica microspheres: Weigh 0.1 g of cetyltrimethylammonium bromide powder and dissolve it in a mixed solution of 5.0 g of ultrapure water, 5.0 g of ethanol and 1.0 mL of ammonium hydroxide; stir vigorously Add 5.0 g of the above polystyrene emulsion, ultrasonicate for 5 min, and stir at room temperature for 10 min; take 0.1 g of ethyl orthosilicate slowly dropwise into the reaction system, and continue to stir for 0.5 h; centrifuge the obtained mixed solution at 5000 rpm for 5 min, use a large amount of The product was washed wit...

Embodiment 2

[0060] 1) Preparation of polystyrene emulsion: Weigh 2.0g of polyvinylpyrrolidone in 0.8L of ultrapure water, transfer to the reactor after the polyvinylpyrrolidone is completely dissolved, add 80g of styrene, purge with nitrogen for 30min, and heat to 80 ℃ and constant temperature stirring for 30min; adding 10.0mL of 2,2'-azobisisobutyramidine hydrochloride, nitrogen protection for 12h to obtain a polystyrene emulsion.

[0061] 2) Preparation of hollow silica microspheres: Weigh 0.8g of cetyltrimethylammonium bromide powder and dissolve it in a mixed solution of 10.0g of ultrapure water, 10.0g of ethanol and 2.0mL of ammonium hydroxide; stir vigorously 25.0 g of the above polystyrene emulsion was added, sonicated for 10 min and stirred at room temperature for 30 min; 1.5 g of ethyl orthosilicate was slowly dropped into the reaction system, and stirred for 0.5 h; the obtained mixed solution was centrifuged at 7000 rpm for 15 min, and a large amount of The product was washed wi...

Embodiment 3

[0067] 1) Preparation of polystyrene emulsion: Weigh 5.0 g of polyvinylpyrrolidone in 1.0 L of ultrapure water, transfer it to the reactor after the polyvinylpyrrolidone is completely dissolved, add 100.0 g of styrene, purge with nitrogen for 60 minutes, and heat to 100 ℃ and constant temperature stirring for 60min; adding 50.0mL 2,2'-azobisisobutyramidine hydrochloride, nitrogen protection for 24h to obtain a polystyrene emulsion.

[0068] 2) Preparation of hollow silica microspheres: Weigh 2.0 g of cetyltrimethylammonium bromide powder and dissolve it in a mixed solution of 20.0 g of ultrapure water, 20.0 g of ethanol and 5.0 mL of ammonium hydroxide; stir vigorously 50.0 g of the above polystyrene emulsion was added, sonicated for 50 min and stirred at room temperature for 60 min; 2.0 g of ethyl orthosilicate was slowly dropped into the reaction system, and stirred for 3.0 h; the obtained mixed solution was centrifuged at 1000 rpm for 30 min, and a large amount of The produ...

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Abstract

Preparation method and application of acellular porcine dermal matrix thermosensitive antibacterial conductive scaffold. Acellular porcine dermal matrix with high biosafety is used as a base material, firstly compounded with nano-silver wires with good biocompatibility, and then through physical adsorption and chemical combination to load temperature-sensitive drug-loaded silica microspheres, and finally obtain a medical conductive stent with both melanoma treatment and tissue repair. It has high sensitivity and antibacterial properties, and can be widely used in the treatment of drug slow-release melanoma skin cancer and the repair of wound tissue in the later stage.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and particularly relates to a preparation method and application of a decellularized pig dermal matrix thermosensitive antibacterial conductive support. Background technique [0002] Melanoma is one of the most aggressive skin cancers, and its incidence has been rising in recent years. As the mainstay of treatment for this type of skin disease, surgery carries a high risk of recurrence and larger skin defects. In addition, rapid repair of damaged tissue after tumor resection is very important for long-term skin healing, while the human body cannot completely heal any full-thickness skin defect larger than 4 cm in diameter by itself. Therefore, it is very necessary to develop a medical scaffold that integrates the properties of cancer treatment and regeneration of defective tissue. SUMMARY OF THE INVENTION [0003] In order to overcome the above-mentioned deficiencies of the prior...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/60A61L27/56A61L27/50A61L27/54A61L27/02A61L27/36A61L27/04A61L27/16C08F292/00C08F220/06C08F220/54C08F222/38C08F112/08
Inventor 王学川郑漫辉刘新华岳欧阳侯梦迪白忠薛崔博强
Owner SHAANXI UNIV OF SCI & TECH
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