Porous cellulose microparticles and method for preparing same
A technology of porous cellulose and cellulose, applied in the field of porous cellulose particles and their preparation, can solve problems such as difficulty in preparing porous cellulose particles
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[0454] The preparation of macroemulsions is well known to those skilled in the art. Macroemulsions are typically prepared using the low-energy or high-energy methods described above for nanoemulsions.
[0455] microemulsion
[0456] In an embodiment, the emulsion in step b) is a microemulsion.
[0457] In an embodiment, one of the two immiscible liquids forming the microemulsion is water or an aqueous solution comprising one or more salts and / or other water-soluble ingredients, preferably water, more preferably distilled water.
[0458] In embodiments, the other of the two immiscible liquids is any water-immiscible organic liquid, such as one or more oils, one or more hydrocarbons (saturated or unsaturated, such as olefins), one or more fluorinated hydrocarbons, one or more long chain esters, one or more fatty acids, etc., and mixtures thereof.
[0459] Non-limiting examples of oils include castor oil, corn oil, coconut oil, evening primrose oil, eucalyptus oil, linseed oil...
Embodiment 1
[0551] Example 1 - Microparticles produced with a nanoemulsion / CNC ratio of 4.64 ml / g
[0552] A 0.73 wt% cCNC+ suspension and a 3.91 wt% cCNC suspension were prepared from the above stock suspensions.
[0553] 0.85 L of Nanoemulsion A was added to 8.5 L of the CNC+ suspension and mixed at 800 rpm. After 5 minutes, 3.1 L of cCNC (3.91 wt %) suspension was added and the mixture was stirred for an additional 30 minutes before spray drying. An additional 3 L of water was added to the mixture to facilitate spray drying of the sample.
[0554] The parameters of the spray dryer are set as follows: inlet temperature 185C, outlet temperature: 85C, feed stroke 28%, nozzle pressure 1.5bar, pressure difference 180mmWc, nozzle air cap 70. This process produces a dry, free-flowing white powder.
[0555] To remove embedded pore formers, 20 g of the spray-dried microparticles were added to 200 mL of isopropanol and mixed for 3 min, then centrifuged at 1200 rpm for 6 min. Repeat this step...
Embodiment 2
[0557] Example 2 - Microparticles produced with a nanoemulsion / CNC ratio of 14.49 ml / g
[0558] A 0.84 wt% cCNC+ suspension and a 4.53 wt% cCNC suspension were prepared from the above stock suspensions.
[0559] 2.6 L of Nanoemulsion A was added to 7.2 L of CNC+ (0.84 wt %) suspension and mixed at 400 rpm. After 5 minutes, 2.6 L of cCNC (4.53% by weight) suspension were added and the mixture was stirred for an additional 5 minutes before spray drying. The mixture was found to be very viscous, so the solids concentration was reduced as follows: 2.2L of distilled water was added to the above mixture (12.4L) to yield a final mixture of 14.6L.
[0560] The spray dryer parameters are the same as in Example 1. This process produces a dry, free-flowing white powder. Porogen removal and product isolation / drying were as described in Example 1.
[0561] A white free-flowing powder formed after 2 hours of drying. Its properties are summarized in Table 1 below. A typical SEM image o...
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