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Oral composition

A technology for composition and oral cavity, which is applied in the direction of drug combination, oral care, cosmetic preparations, etc. It can solve the problems of no mention of astringent feeling, insufficient tightening feeling, etc., to ensure taste, good taste, and excellent stability Effect

Pending Publication Date: 2022-04-05
LION CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In Patent Document 1 (Japanese Patent No. 6441669), hydroxyethyl cellulose as a binder is mixed in a specific amount and in a specific ratio in a water-soluble aluminum salt of an astringent component, thereby adding a water-soluble aluminum salt to the water-soluble aluminum salt. In the liquid oral composition in which the mixing amount is 0.5% by mass or less, harmful effects such as irritation are suppressed and a high gingival tightening feeling is given, but the tightening feeling is not sufficient, and if the water-soluble aluminum salt is excessively mixed, it may will stimulate
[0005] In addition, Patent Document 2 (Japanese Unexamined Patent Publication No. 61-155314) discloses that by mixing hydroxyalkyl cellulose and carrageenan as binders in an oral composition containing a soluble aluminum compound such as aluminum lactate, thereby To improve stability and sticky feeling of use, Patent Document 3 (Japanese Patent Laid-Open No. 2000-178150) discloses that by mixing carboxymethyl cellulose in a liquid oral composition mixed with aluminum lactate and a nonionic surfactant, Sodium, thereby improving the cleaning power and suppressing the irritation of the oral mucosa, but they did not focus on the imparting of the astringent feeling, nor did they mention the astringent feeling

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment I

[0107] [Example 1, Comparative Example 1]

[0108] Dentifrice compositions (toothpaste compositions) having the compositions shown in Tables I-1 to I-3 were prepared by conventional methods, used as test samples, and evaluated by the following method. The results are collectively described in Tables I-1 to I-3.

[0109] In addition, the dentifrice composition containing (A) component has hyperesthesia inhibitory effect.

[0110]

[0111] For the samples just after preparation, five professional panel members of the test subjects conducted the evaluation of sense of use. Put 1 g of the sample on a toothbrush (CLINICA ADVANTAGE toothbrush, 4-row compact, regular type, manufactured by Lion Co., Ltd.), brush your teeth for 3 minutes, rinse your mouth with water, and immediately feel the astringent feeling on the gums (the astringent feeling of the gums) ), the irritation in the oral cavity (whether there is discomfort or irritation), were judged according to the following scor...

Embodiment II

[0145] [Example II, Comparative Example II]

[0146] Toothpaste compositions of the compositions shown in Tables II-1 to II-4 were prepared by a conventional method, contained in a laminated tubular container (120 mm in length, 100 mm in outer circumference, and 2 mm in inner diameter of the nozzle), which was used as a sample, and processed according to the following method to evaluate. The results are collectively described in Tables II-1 to II-4.

[0147]

[0148] The moldability of the samples was evaluated by the ease of placement on a toothbrush. For the samples just after preparation, five professional panel members of the test subjects conducted the evaluation of sense of use. Squeeze 1 g of the toothpaste composition from the tubular container and place it on a toothbrush (CLINICA ADVANTAGE toothbrush, 4-row compact type, ordinary type, manufactured by Lion Co., Ltd.), and determine the ease of placement on the toothbrush according to the following scoring criteri...

Embodiment III

[0182] [Example III, Comparative Example III]

[0183] Dentifrice compositions (toothpaste compositions) having the compositions shown in Tables III-1 to III-3 were prepared by conventional methods, used as test dentifrices, and evaluated by the following method. The results are also described in Tables III-1 to III-3.

[0184]

[0185] The dentin portion of a human molar cut into 1-2 mm was ground only on one side with a file, and the tooth slice was immersed in 37% phosphoric acid aqueous solution for 45 seconds to etch, washed with water, and then ultrasonically cleaned (0 cycle). The dentin portion of the above-mentioned human molars was mixed with the supernatant of the test dentifrice (the test dentifrice was diluted 3 times with artificial saliva, stirred with a vibrator for 10 minutes, and then centrifuged at 10,000 rpm for 10 minutes to obtain the supernatant ) in immersion (artificial saliva diluted 3 times, immersion for 3 minutes), after washing, immersion in ar...

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Abstract

Provided is an oral composition capable of imparting a high astringent feeling while suppressing irritation caused by a water-soluble aluminum salt. An oral composition containing (A) a water-soluble aluminum salt and (B) a cationic polymer compound, the content of component (A) being 0.1-0.5 mass% in terms of aluminum ions, and the ratio {the amount of aluminum ions in component (A)} / (B) being 0.23-5 by mass. The oral composition further contains any one of the following components: (C) one or more selected from the group consisting of nonionic surfactants (C-1) and betaine-type amphoteric surfactants (C-2), (D) an anti-inflammatory component, (E) xanthan gum, (F) one or more selected from the group consisting of silica, calcium carbonate and calcium phosphate, and (G) a water-soluble fluorine compound.

Description

technical field [0001] The present invention relates to an oral composition effective for suppressing or preventing hyperesthesia, which suppresses irritation caused by a water-soluble aluminum salt and imparts a high astringent feeling. Background technique [0002] In order to suppress or prevent symptoms of periodontal disease such as gingival inflammation, various active ingredients such as anti-inflammatory ingredients and bactericidal ingredients are mixed in the oral composition. It is not necessarily sufficient to make the user actually feel the effect such as the tightening of the gums to give a sense of satisfaction. For example, anti-inflammatory components such as tranexamic acid and dipotassium glycyrrhizinate exhibit excellent gingival inflammation-inhibiting effects, but the astringent feeling associated with the firmness of gingival tightening is not considered to be sufficient among these components. [0003] Therefore, water-soluble aluminum compounds such...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/92A61K8/86A61K8/73A61K8/44A61K8/26A61K8/19A61K8/21A61K8/24A61K8/25A61P37/08A61Q11/00
CPCA61K8/73A61Q11/00A61K8/26A61K8/365A61K8/731A61K8/737A61K8/25A61K8/24A61K8/21A61K2800/596
Inventor 饭岛浩内藤香菜小田理加
Owner LION CORP
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