Molnupiravir taste-masking particles and preparation method thereof
A technology of taste-masking granules and granules, which can be used in pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. The effect of drug stability and improving drug taste
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[0025] Example 1
[0026] Molnupiravir particle prescription composition is as follows:
[0027]
[0028] The process of Molnupiravir particles includes the following steps:
[0029] (1) Pre-treatment: molnupiravir gas flow crushing;
[0030] (2) Preparation of adhesive: dissolve the sodium carboxymethylcellulose sodium in 95% as a binder;
[0031] (3) Preparation of Software: Place the molnupiravir, pH regulatory agent, and other excipient compositions in the high shear wet method, and the material is added to the binder solution in a mixed state, and the adhesive solution is atomized. Add in the form, continue to mix evenly, make soft materials;
[0032] (4) Preparation of the particles: prepared a moving flat machine for preparing wet particles, the screen is 40 mesh;
[0033] (5) Drying of the particles: drying the particles by fluidized bed, the control material temperature is 30-50 ° C, controlling the particles of 1% -3%, using a 30 mesh screen.
[0034] (6) Fluidized bed...
Example Embodiment
[0040] Example 2-7
[0041] Example 2-7 The formulation and preparation method of Example 1 were designed to separately designed different pH regulators, different amounts of different binder solutions and weight gains.
[0042]
Example Embodiment
[0043] Example 8
[0044] Explain the effect of Molnupiravir, the effect, the degree of dissolution, the content, uniformity, particle size, solubilization quality indicators, and related content, the detection results of the detection of the effect, dissolution, content of particle size, solubilization quality indicators, and related content:
[0045] 1. Effect of Molnupiravir particle in Example 1 and waterless swallowing
[0046] Sampling method: adult men and women swallow, a total of 20 people
[0047] Detection method: granules oral, waterless swallow
[0048] Test results
[0049]
[0050]
[0051] Conclusion: Molnupiravir particles have a good taste of water, and there is no difficulty in swallowing.
[0052] 2. Study on Molnupiravir Particle Dissolution in Example 1
[0053] Sampling method: in water, pH1.2 hydrochloric acid buffer, pH4.5 acetate buffer, pH 6.8 phosphate buffer is released medium,
[0054] Dissolution measuring method: slurry method, speed of 100R / m...
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