Deuterium-depleted water contact lens eye-moistening liquid and preparation method thereof

A technology of contact lenses and deuterium-depleted water is applied in pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. Radiation protection and activation of immunity, avoid eye irritation, anti-aging effect

Pending Publication Date: 2022-04-15
上海善普生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Antibiotic eye drops can only be used in case of eye infection, if there is no infection, it will only cause damage to the eyes
Chloramphenicol-type eye drops, because chloramphe

Method used

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  • Deuterium-depleted water contact lens eye-moistening liquid and preparation method thereof
  • Deuterium-depleted water contact lens eye-moistening liquid and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The present embodiment provides a deuterium-depleted water contact lens ophthalmic solution.

[0030] Prepared from the following raw materials according to weight percentage: 0.01% boric acid, 0.5% immobilized hyaluronic acid, 0.01% phosphate buffer, 0.001% sodium octadecylsulfonate, 0.001% glycine, polyhexamethylene biguanide Acetate 0.000001%, the balance is deuterium-depleted water. The content of deuterium in the deuterium-depleted water is 110-145ppm.

[0031] Immobilized hyaluronic acid is prepared from the following raw materials by weight:

[0032] 1) chitosan is dissolved in 5wt% acetic acid solution to obtain 5wt% chitosan solution;

[0033] 2) dissolving shellac acid in ethanol to make a concentration of 3wt% shellac acid solution;

[0034] 3) dissolving hyaluronic acid in deionized water to obtain a 3wt% hyaluronic acid solution;

[0035] 4) Mix 100mL chitosan solution and 100mL shellac acid solution, then add 100mL hyaluronic acid solution, add genipin...

Embodiment 2

[0041] The present embodiment provides a deuterium-depleted water contact lens ophthalmic solution.

[0042]Prepared from the following raw materials according to weight percentage: glucose 3%, immobilized hyaluronic acid 2%, citrate buffer 5%, carbomer 1%, ethylenediaminetetraacetic acid 4%, sodium lactate 0.0001%, the balance It is deuterium-depleted water. The content of deuterium in the deuterium-depleted water is 90-110ppm.

[0043] Immobilized hyaluronic acid is prepared from the following raw materials by weight:

[0044] 1) chitosan is dissolved in 15wt% acetic acid solution to obtain 10wt% chitosan solution;

[0045] 2) dissolving shellac acid in ethanol to make a concentration of 7wt% shellac acid solution;

[0046] 3) dissolving hyaluronic acid in deionized water to obtain a 5wt% hyaluronic acid solution;

[0047] 4) Mix 100mL chitosan solution and 100mL shellac acid solution, then add 100mL hyaluronic acid solution, add genipin, the addition amount is 2wt% of t...

Embodiment 3

[0053] The present embodiment provides a deuterium-depleted water contact lens ophthalmic solution.

[0054] Prepared from the following raw materials according to weight percentage: 1.5% sodium chloride, 1% immobilized hyaluronic acid, 2% phosphate buffer, 0.5% Tween-80, 2% sodium edetate, 0.00005 sorbic acid %, the balance is deuterium-depleted water. The content of deuterium in the deuterium-depleted water is 50-90ppm.

[0055] Immobilized hyaluronic acid is prepared from the following raw materials by weight:

[0056] 1) chitosan is dissolved in 10wt% acetic acid solution to obtain 7wt% chitosan solution;

[0057] 2) dissolving shellac acid in ethanol to make a concentration of 5wt% shellac acid solution;

[0058] 3) dissolving hyaluronic acid in deionized water to obtain a 4wt% hyaluronic acid solution;

[0059] 4) Mix 100mL chitosan solution and 100mL shellac acid solution, then add 100mL hyaluronic acid solution, add genipin, the addition amount is 1wt% of the total...

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Abstract

The invention provides a deuterium-depleted water contact lens eye lotion and a preparation method thereof, and belongs to the technical field of ophthalmic liquid medicine. The deuterium-depleted water injection is prepared from the following raw materials in percentage by weight: 0.01-3% of an osmotic pressure regulator, 0.5-2% of immobilized hyaluronic acid, 0.01-5% of a buffering agent, 0.001-1% of a surfactant, 0.001-4% of a chelating agent, 0.000001-0.0001% of a preservative and the balance of deuterium-depleted water. The immobilized hyaluronic acid can exist in the eyes for a long time and has the effects of lubricating the contact lenses for a long time, inhibiting bacteria and keeping the eyes wet, so that the problems of dry eyes, bacterial infection and the like caused by wearing of the contact lenses are effectively avoided, the addition amount of a preservative is reduced, stimulation to the eyes is avoided, and the safety of the contact lenses is improved. Wide application prospects are realized.

Description

technical field [0001] The invention relates to the technical field of ophthalmic medicinal liquids, in particular to a deuterium-depleted water eye moistening liquid for contact lenses and a preparation method thereof. Background technique [0002] With the changes in people's lifestyles and working conditions, people spend more and more time using their eyes, such as looking at computers, watching TV, playing video games, etc. for a long time, and are very prone to visual fatigue and dry eye syndrome. Eye drops have unknowingly become a must-have item for office workers. Many people drip a couple of drops from time to time to relieve discomfort. In fact, doing so is very harmful. In order to keep the sterility of the medicine and prolong the validity period of the medicine, preservatives are added to guarantee the quality. Because most of the eye drops contain preservatives, it will damage the conjunctival goblet cells in the eyes. Such as the conjunctival cup shape, if ...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/728A61K47/36A61P27/04
Inventor 葛强
Owner 上海善普生物科技有限公司
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