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Preparation method of taurine

A technology of taurine and sodium taurine, applied in the directions of sulfonate preparation, chemical instruments and methods, physical/chemical process catalysts, etc., can solve the problems of complicated catalyst preparation, increase production cost, etc., and achieve the reaction time of aminolysis Shorter, higher conversion, higher yield per pass

Active Publication Date: 2022-04-15
ZHEJIANG NHU PHARMA +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] Patents CN111269151A, CN111689880A, CN111574412A use Zr 2 MoO 4 (PO 4 ) 2 , Pd-C / Al 2 o 3 Shape-selective catalyst, BaCaTiO 4 And other types of heterogeneous catalysts are used as catalysts for ammonolysis. Compared with conventional basic catalysts, the required reaction conditions are milder, and the reaction time is also shortened. However, the preparation of the catalyst is too complicated, which increases the production cost.

Method used

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  • Preparation method of taurine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Pump 200kg of 25% ammonia water into the dissolution kettle, add 0.68kg of catalyst zinc particles, stir and dissolve. Add 40 kg of liquid ammonia and 170 kg of 40% sodium isethionate aqueous solution, and stir to obtain a mixture. After the mixture is pressurized to 8MPa by a high-pressure pump, it is first heated to 200°C by a heat conduction oil preheater, and then enters an ammonolysis reactor for reaction. The ammonolysis reaction temperature is 200°C, the pressure is 8 MPa, and the sodium taurate solution is obtained after 30 minutes of reaction. After removing ammonia and concentrating to remove water, 317.86 kg of sodium taurine aqueous solution was obtained. Sampling was carried out to detect the content of sodium taurine at 20.0%, and the yield of sodium taurine was calculated to be 94.10%.

[0040] 317.86kg sodium taurate aqueous solution forwardly passes through 159L weakly acidic 110 resin with 1.2BV / h flow velocity, when outlet feed liquid pH is close to...

Embodiment 2

[0043] Pump 250kg of 25% ammonia water into the dissolution tank, add 1.2kg of nickel acetate catalyst, and stir to dissolve. 30 kg of liquid ammonia and 200 kg of 35% sodium isethionate aqueous solution were introduced, and the mixture was uniformly stirred. After the mixture is pressurized to 6MPa by a high-pressure pump, it is first heated to 180°C by a heat transfer oil preheater. Enter the ammonolysis reactor to react, the ammonolysis reaction temperature is 180°C, the pressure is 6MPa, and the sodium taurate solution is obtained after the reaction for 45min. After removing ammonia and concentrating to remove water, 328.4 kg of sodium taurine aqueous solution was obtained. Sampling was carried out to detect the content of sodium taurine at 20.5%, and the yield of sodium taurine was calculated to be 96.8%.

[0044] 328.4kg sodium taurate aqueous solution forwardly passes through 192L weakly acidic 110 resin with 1.1BV / h flow rate, when outlet feed liquid pH is close to 8...

Embodiment 3

[0046] Pump 150kg of 25% ammonia water to the dissolution kettle, add 0.82kg of chromium trioxide catalyst, stir and dissolve. 40 kg of liquid ammonia and 100 kg of 35% sodium isethionate aqueous solution were introduced, and the mixture was uniformly stirred. After the mixture is pressurized to 10MPa by a high-pressure pump, it is first heated to 195°C by a heat transfer oil preheater. Enter the ammonolysis reactor to react, the ammonolysis reaction temperature is 195 ° C, the pressure is 10 MPa, and the sodium taurate solution is obtained after 30 minutes of reaction. After removing ammonia and concentrating to remove water, 169.3 kg of sodium taurine aqueous solution was obtained. Sampling was carried out to detect the content of sodium taurine at 19%, and the yield of sodium taurine was calculated to be 92.5%.

[0047] 169.3kg sodium taurate aqueous solution forwardly passes through 92L weakly acidic 110 resins with 0.9BV / h flow velocity, when outlet feed liquid pH is cl...

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Abstract

The invention discloses a taurine preparation method, which comprises: (1) in the presence of an ammonia water complex ion catalyst, carrying out an ammonolysis reaction on a sodium isethionate aqueous solution and ammonia to obtain a reaction solution containing sodium taurate; (2) performing deamination, concentration and water removal, acidification and crystallization on the reaction liquid containing sodium taurate to obtain taurine and mother liquor; the ammonia water complexing ion catalyst is obtained by complexing ammonia and a catalyst precursor, and the catalyst precursor contains one or more metal elements of chromium, zinc, nickel, cobalt, copper and silver. The method has the advantages of mild process conditions, short reaction time, high yield, simple catalyst source and the like.

Description

technical field [0001] The invention belongs to the field of preparation of pharmaceutical intermediates, in particular to a method for preparing taurine. Background technique [0002] Taurine (2-aminoethanesulfonic acid), also known as taurocholic acid and taurobilin, is white crystal or powder, odorless, non-toxic, and slightly sour. It is a non-protein amino acid, one of the important amino acids necessary for the human body, and has unique pharmacological and nutritional health effects. Taurine can be widely used in medicine, food additives, optical brighteners, organic synthesis and other fields, and can also be used as biochemical reagents, wetting agents, buffers, etc. Western developed countries have generally used taurine in medicine and food additives. [0003] The chemical synthesis method of taurine mainly contains ethanolamine method and ethylene oxide method, and ethanolamine method uses ethanolamine as raw material, two-step synthetic taurine, but wherein es...

Claims

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Application Information

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IPC IPC(8): C07C303/30C07C309/14B01J31/18
CPCC07C303/30B01J31/1805B01J2531/26B01J2531/847B01J2531/62B01J2531/845B01J2531/842B01J2531/17C07C309/14C07C303/44
Inventor 徐淞华姚祥华宋银江何孝祥程丽欢李凤潘映霞章萍萍
Owner ZHEJIANG NHU PHARMA
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