Hydrogel capable of releasing metformin with pH/glucose dual-responsiveness as well as preparation method and application of hydrogel

A metformin-responsive technology, applied in pharmaceutical formulations, bandages, drug delivery, etc., can solve problems such as low electrical conductivity, difficult angiogenesis, and low antioxidant capacity, and achieve the effects of promoting blood circulation, repairing blood vessels, and promoting healing

Active Publication Date: 2022-04-29
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In order to solve the problems in the prior art, the gel dressing for diabetic wounds has insufficient adhesion performance, low oxidation resistance, difficult angiogenesis at the wound and low electrical conductivity

Method used

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  • Hydrogel capable of releasing metformin with pH/glucose dual-responsiveness as well as preparation method and application of hydrogel
  • Hydrogel capable of releasing metformin with pH/glucose dual-responsiveness as well as preparation method and application of hydrogel
  • Hydrogel capable of releasing metformin with pH/glucose dual-responsiveness as well as preparation method and application of hydrogel

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0048] The invention discloses a method for preparing a hydrogel with pH / glucose double-responsive metformin release, which specifically includes the following steps:

[0049] Step 1, under the effect of 1-(3-dimethylpropyl)-3-ethylcarbodiimide hydrochloride (EDC), dihydrocaffeic acid is grafted onto the chitosan backbone to generate a shell Polysaccharide grafted dihydrocaffeic acid (CS-DA);

[0050] The specific preparation steps of chitosan grafted dihydrocaffeic acid include:

[0051] (1A) 0.523g chitosan was dissolved in 45mL deionized water, stirred at room temperature to make it fully dissolved;

[0052] (1B) adding 1M hydrochloric acid to the solution obtained in (1A) to adjust the pH of the solution to about 5.0 to form a chitosan solution;

[0053] (1C) Add 0.30-1.2g of dihydrocaffeic acid into the chitosan solution obtained in the above (1B) to form a mixed solution A; quickly add 0.62-2.48g of 1-(3-dimethylamino in the mixed solution A Propyl)-3-ethylcarbodiimid...

Embodiment 1

[0083] (1) Under the action of 1-(3-dimethylpropyl)-3-ethylcarbodiimide hydrochloride (EDC), dihydrocaffeic acid is grafted onto the chitosan backbone to generate chitosan Sugar-grafted dihydrocaffeic acid (CS-DA):

[0084] (1A) 0.523g chitosan was dissolved in 45mL deionized water, stirred at room temperature to make it fully dissolved;

[0085] (1B) adding 1M hydrochloric acid to the solution obtained in (1A) to adjust the pH of the solution to about 5.0;

[0086] (1C) Add 0.591g of dihydrocaffeic acid into the solution obtained in (1B) above, and quickly add 1.239g of EDC, stir well to make the solution evenly mixed;

[0087] (1D) Add 1M hydrochloric acid to the solution obtained in (1C) to adjust the pH value of the solution between 5.0 and 6.0, and stir for 8 hours;

[0088] (1E) Adjust the pH of the dialysis water to 5 with 1M hydrochloric acid, and dialyze the solution obtained in (1D) therein for 72 hours.

[0089](2A) 0.565g L-arginine was dissolved in 20mL deioniz...

Embodiment 2

[0106] The difference from Example 1 is that the 1.5wt% CDL solution in step (5) was replaced by 2.25wt%, and the obtained hydrogel was named PC2.

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Abstract

The invention relates to hydrogel capable of releasing metformin with pH/glucose dual responsiveness and a preparation method and application of the hydrogel. The preparation method comprises the following steps: adding polydopamine-coated reduced graphene oxide (rGO (at) PDA) and metformin (Met) into a benzaldehyde and phenylboronic acid dual-modified polyethylene glycol copolymer (PPB) solution at the same time; and then mixing with a dihydrocaffeic acid and L-arginine co-grafted chitosan (CDL) solution, and carrying out crosslinking through Schiff base and phenyl borate to form the pH/glucose dual-responsive PC/GO/Met hydrogel. The method is wide in raw material source, simple in preparation process and low in preparation cost, and the prepared hydrogel dressing has double responsiveness, can release drugs beneficial to wound healing of type II diabetes mellitus and promote wound healing of diabetes mellitus, has the characteristic of pH/glucose double-responsiveness metformin release, and can be applied to the field of wound healing of type II diabetes mellitus and wound healing of type II diabetes mellitus. And good adhesion, antibacterial property, oxidation resistance, blood coagulation and in-vivo hemostasis capability are realized.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a hydrogel capable of releasing metformin with pH / glucose dual responsiveness, its preparation method and application. Background technique [0002] Diabetes is one of the chronic diseases with the highest incidence rate in the world. Vascular lesions often occur around the lower limbs of diabetic patients, resulting in insufficient blood supply to the wounds of the feet, which is also the main reason for the difficulty in wound healing in diabetic patients. Statistics show that among the 3 million patients hospitalized for diabetes in the United States, about 20% are due to foot ulcers and their complications. In addition, hyperglycemia, chronic inflammation, poor angiogenesis, and granulation tissue formation are also common problems in diabetic wounds. These factors cause diabetic wounds to take longer to heal than normal wounds, resulting in chronic ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
CPCA61L26/008A61L26/0066A61L26/0061A61L26/0023A61L26/0019A61L26/0004A61L2300/412A61L2300/404A61L2300/418A61L2400/04C08L5/08C08L79/02C08L71/02
Inventor 郭保林乔博雯梁永平
Owner XI AN JIAOTONG UNIV
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